Article: Synthesis of Phospho-Amino Acid Analogues as Tissue Adhesive Cement Additives.
ACS central science
2020 Volume 6, Issue 2, Page(s) 226–231
Abstract: In this paper we report the synthesis of a library of phospho-amino acid analogues, via a novel ... phosphotyrosine analogues were then applied as additives to create adhesive calcium phosphate cements, allowing ... of multiple calcium binding motifs in mediating adhesion, as well as highlighting the crucial role played ...
| Abstract | In this paper we report the synthesis of a library of phospho-amino acid analogues, via a novel single-step allyl-phosphoester protection/Pd-mediated deprotection strategy. These phosphoserine and phosphotyrosine analogues were then applied as additives to create adhesive calcium phosphate cements, allowing us to probe the chemical origins of the increased surface binding strength. We demonstrate the importance of multiple calcium binding motifs in mediating adhesion, as well as highlighting the crucial role played by substrate hydrophobicity and orientation in controlling binding strength. |
|---|---|
| Language | English |
| Publishing date | 2020-02-11 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 2374-7943 |
| ISSN | 2374-7943 |
| DOI | 10.1021/acscentsci.9b01149 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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