Article: Resolution of immune response by recombinant transforming growth factor-beta (rTGF-β) during influenza A virus infection.
The Indian journal of medical research
2012 Volume 136, Issue 4, Page(s) 641–648
Abstract: ... by recombinant transforming growth factor- β1 (rTGF-β1) has not been studied. Therefore, in the present study ... The immune response to influenza A virus was characterized by an influx of both macrophages and lymphocytes ... of influenza A/Udorn/317/72 (H3N2) virus, and the survival rate, virus titre, histopathological changes and ...
| Abstract | Background & objectives: Replication of influenza A virus in the respiratory tract leads to cell damage and liberation of cytokines and chemokines. The in vivo cytokine induction and modulation by recombinant transforming growth factor- β1 (rTGF-β1) has not been studied. Therefore, in the present study the effect of rTGF-β1, a potent immunomodulatory cytokine which has anti-inflammatory properties and downregulates the release of inflammatory molecules, against influenza-virus infection in the airway of mice was investigated. Methods: rTGF-β1 was administered intravenously to mice with concomitant intranasal infection of influenza A/Udorn/317/72 (H3N2) virus, and the survival rate, virus titre, histopathological changes and levels of factors regulating inflammation in the airway fluid were analysed. Result: The immune response to influenza A virus was characterized by an influx of both macrophages and lymphocytes into the lungs of the infected host. rTGF-β1 significantly suppressed virus multiplication and improved the survival rate of mice. rTGF-β1 downregulated infiltration of neutrophils and the release of inflammatory molecules, such as interferon-gamma (IFN-γ), interleukin-1 β (IL-1β) and stimulated release of IL-10 that potentiates anti-inflammatory response into airway. Interpretation & conclusions: A generalized pulmonary inflammation does not contribute to viral clearance but represents an immunological background within which antiviral immunity operates. Treatment with rTGF-β1 reduced macrophage count and neutrophils influx in lungs of infected mice. |
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| MeSH term(s) | Administration, Intravenous ; Analysis of Variance ; Animals ; Bronchoalveolar Lavage Fluid/immunology ; Cytokines/immunology ; Influenza A virus ; Lung/immunology ; Lymphocytes/immunology ; Macrophages/immunology ; Mice ; Mice, Inbred BALB C ; Orthomyxoviridae Infections/immunology ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/immunology ; Recombinant Proteins/pharmacology ; Respiratory System/virology ; Survival Rate ; Transforming Growth Factor beta/administration & dosage ; Transforming Growth Factor beta/immunology ; Transforming Growth Factor beta/pharmacology ; Virus Replication/immunology | |||||
| Chemical Substances | Cytokines ; Recombinant Proteins ; Transforming Growth Factor beta | |||||
| Language | English | |||||
| Publishing date | 2012-11-12 | |||||
| Publishing country | India | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 390883-5 | |||||
| ISSN | 0971-5916 ; 0019-5340 | |||||
| ISSN | 0971-5916 ; 0019-5340 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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