Article: Update on the management of Lennox-Gastaut syndrome with a focus on rufinamide.
Neuropsychiatric disease and treatment
2009 Volume 5, Page(s) 547–551
Abstract: ... to the treatment of Lennox-Gastaut syndrome as well as studies involving rufinamide as an anticonvulsant medication ... side effects.: Conclusions: Rufinamide is a promising adjunctive therapy for Lennox-Gastaut syndrome ... Objective: This review summarizes the treatment of Lennox-Gastaut syndrome, an intractable ...
| Abstract | Objective: This review summarizes the treatment of Lennox-Gastaut syndrome, an intractable epileptic encephalopathy of early childhood. In particular, the review focuses on rufinamide, a recently released anticonvulsant medication with reported effectiveness in this epilepsy syndrome. Methods: A systematic literature search (PubMed) was performed to review the existing literature pertaining to the treatment of Lennox-Gastaut syndrome as well as studies involving rufinamide as an anticonvulsant medication. Results: The published literature to date documents a beneficial effect of rufinamide on children over 4 years old with Lennox-Gastaut syndrome. Studies indicate a significant decrease in tonic and atonic seizure frequency as well as total seizure frequency compared to placebo-treated children. Rufinamide appears to be well tolerated and a safe medication, somnolence and vomiting being the most common side effects. Conclusions: Rufinamide is a promising adjunctive therapy for Lennox-Gastaut syndrome, an intractable childhood epilepsy. To ensure its optimal effectiveness, clinicians must be familiar with the medication's clinical response profile and potential for adverse effects. |
|---|---|
| Language | English |
| Publishing date | 2009-11-02 |
| Publishing country | New Zealand |
| Document type | Journal Article |
| ZDB-ID | 2186503-6 |
| ISSN | 1178-2021 ; 1176-6328 |
| ISSN (online) | 1178-2021 |
| ISSN | 1176-6328 |
| DOI | 10.2147/ndt.s5300 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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