Article: Molecular discoveries alter our view of inflammatory bowel disease. A review from scientific, clinical, and laboratory perspectives.
American journal of clinical pathology
2003 Volume 119, Issue 4, Page(s) 524–539
Abstract: Within the past decade, knowledge of the molecular basis of inflammatory bowel disease (IBD ... involving the human genome. Furthermore, a shared interest between molecular biologists and clinical ... tumor necrosis factor alpha has improved our understanding of IBD. Our understanding of these molecules and other scientific ...
| Abstract | Within the past decade, knowledge of the molecular basis of inflammatory bowel disease (IBD), including Crohn disease (CD) and ulcerative colitis, has advanced owing to the explosive growth of research involving the human genome. Furthermore, a shared interest between molecular biologists and clinical researchers has contributed to an emerging understanding of IBD. Nucleotide-binding oligomerization domain 2 (NOD2) belongs to an apoptotic regulatory family of genes and has been linked to CD. In addition, research into nuclear factor kappa B (NF-kappa B), the proteasome, interleukins, and tumor necrosis factor alpha has improved our understanding of IBD. Our understanding of these molecules and other scientific discoveries offers hope for new diagnostic tests and therapeutic agents. In the future, genetic markers will predict disease susceptibility, therapeutic responsiveness, and long-term sequelae of modern therapeutics. Also on the horizon, molecular markers promise to define disease heterogeneity, thereby providing a rational basis for patient-specific therapies. The molecular discoveries that are changing our views of IBD will affect the clinician, the laboratory professional, and the patient. |
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| MeSH term(s) | Carrier Proteins/genetics ; Genome, Human ; Humans ; Inflammatory Bowel Diseases/genetics ; Inflammatory Bowel Diseases/pathology ; Intracellular Signaling Peptides and Proteins ; Molecular Biology/methods ; Nod2 Signaling Adaptor Protein | |||||
| Chemical Substances | Carrier Proteins ; Intracellular Signaling Peptides and Proteins ; NOD2 protein, human ; Nod2 Signaling Adaptor Protein | |||||
| Language | English | |||||
| Publishing date | 2003-04 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 2944-0 | |||||
| ISSN | 1943-7722 ; 0002-9173 | |||||
| ISSN (online) | 1943-7722 | |||||
| ISSN | 0002-9173 | |||||
| DOI | 10.1309/7W3E-TL9N-Q9RH-HX61 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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