Article ; Online: Reactive T Cells in Convalescent COVID-19 Patients With Negative SARS-CoV-2 Antibody Serology.
2021 Volume 12, Page(s) 687449
Abstract: ... of induction and persistence of SARS-CoV-2-reactive T cells in these convalescent individuals. Using ... Despite RT-PCR confirmed COVID-19, specific antibodies to SARS-CoV-2 spike are undetectable ... flow cytometry, we assessed specific SARS-CoV-2 and human endemic coronaviruses (HCoV-229E, -OC43) reactive ...
| Abstract | Despite RT-PCR confirmed COVID-19, specific antibodies to SARS-CoV-2 spike are undetectable in serum in approximately 10% of convalescent patients after mild disease course. This raises the question of induction and persistence of SARS-CoV-2-reactive T cells in these convalescent individuals. Using flow cytometry, we assessed specific SARS-CoV-2 and human endemic coronaviruses (HCoV-229E, -OC43) reactive T cells after stimulation with spike and nucleocapsid peptide pools and analyzed cytokine polyfunctionality (IFN |
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| MeSH term(s) | Adult ; CD4-Positive T-Lymphocytes/immunology ; COVID-19/immunology ; COVID-19 Serological Testing ; Cells, Cultured ; Convalescence ; Coronavirus 229E, Human/physiology ; Coronavirus Nucleocapsid Proteins/immunology ; Female ; Humans ; Lymphocyte Activation ; Male ; Middle Aged ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/immunology |
| Chemical Substances | Coronavirus Nucleocapsid Proteins ; Spike Glycoprotein, Coronavirus |
| Language | English |
| Publishing date | 2021-07-12 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2606827-8 |
| ISSN | 1664-3224 ; 1664-3224 |
| ISSN (online) | 1664-3224 |
| ISSN | 1664-3224 |
| DOI | 10.3389/fimmu.2021.687449 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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