Article ; Online: N-Acetyl-L-cysteine inhibits sulfur mustard-induced and TRPA1-dependent calcium influx.
2017 Volume 91, Issue 5, Page(s) 2179–2189
Abstract: ... on the ion channel TRPA1. In this study, we demonstrate that sulfur mustard (bis-(2-chloroethyl) sulfide, SM ... cation channel (TRPA1), is involved in pain, itch, and various diseases, suggesting TRPA1 as a potential ... activates the human TRPA1 (hTRPA1) in a dose-dependent manner measured by the increase in intracellular Ca ...
| Abstract | Transient receptor potential family channels (TRPs) have been identified as relevant targets in many pharmacological as well as toxicological studies. TRP channels are ubiquitously expressed in different tissues and act among others as sensors for different external stimuli, such as mechanical stress or noxious impacts. Recent studies suggest that one member of this family, the transient receptor potential ankyrin 1 cation channel (TRPA1), is involved in pain, itch, and various diseases, suggesting TRPA1 as a potential therapeutic target. As a nociceptor, TRPA1 is mainly activated by noxious or electrophilic compounds, including alkylating substances. Previous studies already revealed an impact of 2-chloroethyl-ethyl sulfide on the ion channel TRPA1. In this study, we demonstrate that sulfur mustard (bis-(2-chloroethyl) sulfide, SM) activates the human TRPA1 (hTRPA1) in a dose-dependent manner measured by the increase in intracellular Ca |
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| Language | English | |||||
| Publishing date | 2017-05 | |||||
| Publishing country | Germany | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 124992-7 | |||||
| ISSN | 1432-0738 ; 0340-5761 | |||||
| ISSN (online) | 1432-0738 | |||||
| ISSN | 0340-5761 | |||||
| DOI | 10.1007/s00204-016-1873-x | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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