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  1. Article ; Online: New Emerging Developments of Platelets in Transfusion Medicine.

    Stolla, Moritz / Kapur, Rick / Semple, John W

    Transfusion medicine reviews

    2020  Volume 34, Issue 4, Page(s) 207–208

    MeSH term(s) Blood Platelets/physiology ; Blood Preservation/adverse effects ; Blood Preservation/methods ; Humans ; Platelet Transfusion/adverse effects ; Platelet Transfusion/methods ; Platelet-Rich Plasma/physiology ; Thrombocytopenia/immunology ; Thrombocytopenia/physiopathology ; Thrombocytopenia/therapy
    Keywords covid19
    Language English
    Publishing date 2020-10-07
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 639107-2
    ISSN 1532-9496 ; 0887-7963
    ISSN (online) 1532-9496
    ISSN 0887-7963
    DOI 10.1016/j.tmrv.2020.09.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020.

    Everts, Peter / Onishi, Kentaro / Jayaram, Prathap / Lana, José Fábio / Mautner, Kenneth

    International journal of molecular sciences

    2020  Volume 21, Issue 20

    Abstract: ... have been suggested. In this review, we will discuss recent developments regarding PRP preparation and ... Emerging autologous cellular therapies that utilize platelet-rich plasma (PRP) applications have ... the potential to play adjunctive roles in a variety of regenerative medicine treatment plans. There is a global ...

    Abstract Emerging autologous cellular therapies that utilize platelet-rich plasma (PRP) applications have the potential to play adjunctive roles in a variety of regenerative medicine treatment plans. There is a global unmet need for tissue repair strategies to treat musculoskeletal (MSK) and spinal disorders, osteoarthritis (OA), and patients with chronic complex and recalcitrant wounds. PRP therapy is based on the fact that platelet growth factors (PGFs) support the three phases of wound healing and repair cascade (inflammation, proliferation, remodeling). Many different PRP formulations have been evaluated, originating from human, in vitro, and animal studies. However, recommendations from in vitro and animal research often lead to different clinical outcomes because it is difficult to translate non-clinical study outcomes and methodology recommendations to human clinical treatment protocols. In recent years, progress has been made in understanding PRP technology and the concepts for bioformulation, and new research directives and new indications have been suggested. In this review, we will discuss recent developments regarding PRP preparation and composition regarding platelet dosing, leukocyte activities concerning innate and adaptive immunomodulation, serotonin (5-HT) effects, and pain killing. Furthermore, we discuss PRP mechanisms related to inflammation and angiogenesis in tissue repair and regenerative processes. Lastly, we will review the effect of certain drugs on PRP activity, and the combination of PRP and rehabilitation protocols.
    MeSH term(s) Adaptive Immunity ; Aging ; Analgesics/pharmacology ; Angiogenesis Inducing Agents/pharmacology ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Cellular Senescence ; Humans ; Immunity, Innate ; In Vitro Techniques ; Osteoarthritis/therapy ; Platelet Transfusion/methods ; Platelet-Rich Plasma/cytology ; Platelet-Rich Plasma/physiology ; Rehabilitation ; Serotonin/metabolism ; Terminology as Topic
    Chemical Substances Analgesics ; Angiogenesis Inducing Agents ; Anti-Inflammatory Agents, Non-Steroidal ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2020-10-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21207794
    Database MEDical Literature Analysis and Retrieval System OnLINE

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