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  1. Article ; Online: Systematic evaluation of immune regulation and modulation.

    Stroncek, David F / Butterfield, Lisa H / Cannarile, Michael A / Dhodapkar, Madhav V / Greten, Tim F / Grivel, Jean Charles / Kaufman, David R / Kong, Heidi H / Korangy, Firouzeh / Lee, Peter P / Marincola, Francesco / Rutella, Sergio / Siebert, Janet C / Trinchieri, Giorgio / Seliger, Barbara

    Journal for immunotherapy of cancer

    2017  Volume 5, Page(s) 21

    Abstract: ... assessment of immune regulation and modulation. In this review, the tumor microenvironment, microbiome ... systematic approaches to monitor the immune response and to interpret the data obtained from these assays ... consisting of multidisciplinary experts from industry, academia, and government focused on the systematic ...

    Abstract Cancer immunotherapies are showing promising clinical results in a variety of malignancies. Monitoring the immune as well as the tumor response following these therapies has led to significant advancements in the field. Moreover, the identification and assessment of both predictive and prognostic biomarkers has become a key component to advancing these therapies. Thus, it is critical to develop systematic approaches to monitor the immune response and to interpret the data obtained from these assays. In order to address these issues and make recommendations to the field, the Society for Immunotherapy of Cancer reconvened the Immune Biomarkers Task Force. As a part of this Task Force, Working Group 3 (WG3) consisting of multidisciplinary experts from industry, academia, and government focused on the systematic assessment of immune regulation and modulation. In this review, the tumor microenvironment, microbiome, bone marrow, and adoptively transferred T cells will be used as examples to discuss the type and timing of sample collection. In addition, potential types of measurements, assays, and analyses will be discussed for each sample. Specifically, these recommendations will focus on the unique collection and assay requirements for the analysis of various samples as well as the high-throughput assays to evaluate potential biomarkers.
    MeSH term(s) Biomarkers, Tumor/immunology ; Humans ; Immunologic Factors/genetics ; Immunotherapy ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy ; T-Lymphocytes/immunology ; Tumor Microenvironment/immunology
    Chemical Substances Biomarkers, Tumor ; Immunologic Factors
    Language English
    Publishing date 2017-03-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1186/s40425-017-0223-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Non-coding RNAs in exercise immunology: A systematic review.

    Kotewitsch, Mona / Heimer, Melina / Schmitz, Boris / Mooren, Frank C

    Journal of sport and health science

    2023  Volume 13, Issue 3, Page(s) 311–338

    Abstract: ... RNAs (ncRNAs) also involved in immune system regulation, heterogeneity in individual study designs and ... qualitative analysis was used to identify and categorize ncRNAs participating in immune modulation by physical exercise ... with known targets in the immune system is missing from the literature. A systematic review and ...

    Abstract Regular physical exercise has been recognized as a potent modulator of immune function, with its effects including enhanced immune surveillance, reduced inflammation, and improved overall health. While strong evidence exists that physical exercise affects the specific expression and activity of non-coding RNAs (ncRNAs) also involved in immune system regulation, heterogeneity in individual study designs and analyzed exercise protocols exists, and a condensed list of functional, exercise-dependent ncRNAs with known targets in the immune system is missing from the literature. A systematic review and qualitative analysis was used to identify and categorize ncRNAs participating in immune modulation by physical exercise. Two combined approaches were used: (a) a systematic literature search for "ncRNA and exercise immunology", (b) and a database search for microRNAs (miRNAs) (miRTarBase and DIANA-Tarbase v8) aligned with known target genes in the immune system based on the Reactome database, combined with a systematic literature search for "ncRNA and exercise". Literature searches were based on PubMed, Web of Science, and SPORTDiscus; and miRNA databases were filtered for targets validated by in vitro experimental data. Studies were eligible if they reported on exercise-based interventions in healthy humans. After duplicate removal, 95 studies were included reporting on 164 miRNAs, which were used for the qualitative synthesis. Six studies reporting on long-noncoding RNAs (lncRNAs) or circular RNAs were also identified. Results were analyzed using ordering tables that included exercise modality (endurance/resistance exercise), acute or chronic interventions, as well as the consistency in reported change between studies. Evaluation criteria were defined as "validated" with 100% of ≥3 independent studies showing identical direction of regulation, "plausible" (≥80%), or "suggestive" (≥70%). For resistance exercise, upregulation of miR-206 was validated while downregulation of miR-133a appeared plausible. For endurance exercise, 15 miRNAs were categorized as validated, with 12 miRNAs being consistently elevated and 3 miRNAs being downregulated, most of them after acute exercise training. In conclusion, our approach provides evidence that miRNAs play a major role in exercise-induced effects on the innate and adaptive immune system by targeting different pathways affecting immune cell distribution, function, and trafficking as well as production of (anti-)inflammatory cytokines. miRNAs miR-15, miR-29c, miR-30a, miR-142/3, miR-181a, and miR-338 emerged as key players in mediating the immunomodulatory effects of exercise predominantly after acute bouts of endurance exercise.
    MeSH term(s) Humans ; Exercise/physiology ; MicroRNAs ; RNA, Untranslated ; Immune System/physiology
    Chemical Substances MicroRNAs ; RNA, Untranslated
    Language English
    Publishing date 2023-11-03
    Publishing country China
    Document type Journal Article ; Systematic Review ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2673028-5
    ISSN 2213-2961 ; 2095-2546
    ISSN (online) 2213-2961
    ISSN 2095-2546
    DOI 10.1016/j.jshs.2023.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Increased plasma/serum levels of prolactin in systemic lupus erythematosus: a systematic review and meta-analysis.

    Wang, Peng / Lv, Tian-Tian / Guan, Shi-Yang / Li, Hong-Miao / Leng, Rui-Xue / Zou, Yan-Feng / Pan, Hai-Feng

    Postgraduate medicine

    2017  Volume 129, Issue 1, Page(s) 126–132

    Abstract: ... in the regulation of humoral and cell mediated immune responses. PRL levels have been investigated ... in several autoimmune diseases including systemic lupus erythematosus (SLE), however, yielded different and inconsistent results ... in English, which comparing plasma/serum PRL levels between SLE group and control group were searched ...

    Abstract Background: Prolactin (PRL), a polypeptide hormone produced by the pituitary gland, is involved in the regulation of humoral and cell mediated immune responses. PRL levels have been investigated in several autoimmune diseases including systemic lupus erythematosus (SLE), however, yielded different and inconsistent results. This study aims to derive a more precise evaluation on plasma/serum PRL levels in SLE patients, as well as the potential influential factors.
    Methods: Studies published from 1 January 1987 to 31 December 2015 in English, which comparing plasma/serum PRL levels between SLE group and control group were searched in PubMed, EMBASE and The Cochrane Library databases. Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by fixed-effects or random-effect model analysis. Heterogeneity test was performed by the Q statistic and quantified using I
    Results: Five-hundred and forty-seven articles were obtained after searching databases, and 12 studies with 429 SLE patients and 326 controls were finally included. Meta-analysis revealed that, compared with the control group, the SLE group had significantly higher plasma/serum PRL levels (P < 0.001), with the SMD of 1.26 and 95%CI (0.70，1.82). Subgroup analyses showed that SLE patients from Asia and Europe had higher plasma/serum PRL levels. However, no significant change in plasma/serum PRL levels was observed in SLE patients from America (P > 0.05).
    Conclusions: Overall, our study suggests that SLE patients have higher plasma/serum PRL level, but with a regional difference.
    MeSH term(s) Adult ; Europe ; Female ; Humans ; Immunomodulation ; Lupus Erythematosus, Systemic/blood ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/physiopathology ; Male ; Middle Aged ; Prolactin/blood
    Chemical Substances Prolactin (9002-62-4)
    Language English
    Publishing date 2017-01
    Publishing country England
    Document type Comparative Study ; Journal Article ; Meta-Analysis ; Review
    ZDB-ID 410138-8
    ISSN 1941-9260 ; 0032-5481
    ISSN (online) 1941-9260
    ISSN 0032-5481
    DOI 10.1080/00325481.2017.1241130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Metaproteomic investigation to assess gut microbiota shaping in newborn mice: A combined taxonomic, functional and quantitative approach

    Levi Mortera, Stefano / Soggiu, Alessio / Vernocchi, Pamela / Del Chierico, Federica / Piras, Cristian / Carsetti, Rita / Marzano, Valeria / Britti, Domenico / Urbani, Andrea / Roncada, Paola / Putignani, Lorenza

    Journal of proteomics. 2019 July 15, v. 203

    2019  

    Abstract: ... among different bacterial species. We also focused on host mucosal proteome and its modulation, according ... to the functional and taxonomic classification, particularly with proteins from orthologues groups. This allowed ... to the development of an efficient immune system. In the last decade, a consistent number of pieces of evidence ...

    Abstract Breastfeeding is nowadays known to be one of the most critical factors contributing to the development of an efficient immune system. In the last decade, a consistent number of pieces of evidence demonstrated the relationship between a healthy organism and its gut microbiota. However, this link is still not fully understood and requires further investigation. We recently adopted a murine model to describe the impact of either maternal milk or parental genetic background, on the composition of the gut microbial population in the first weeks of life. A metaproteomic approach to such complex environments is a big challenge that requires a strong effort in both data production and analysis, including the set-up of dedicated multitasking bioinformatics pipelines. Herein we present an LC-MS/MS based investigation to monitor mouse gut microbiota in the early life, aiming at characterizing its functions and metabolic activities together with a taxonomic description in terms of operational taxonomic units. We provided a quantitative evaluation of bacterial metaproteins, taking into account differential expression results in relation to the functional and taxonomic classification, particularly with proteins from orthologues groups. This allowed the reduction of the bias arising from the presence of a high number of shared peptides, and proteins, among different bacterial species. We also focused on host mucosal proteome and its modulation, according to different microbiota composition.This paper would represent a reference work for investigations on gut microbiota in early life, from both a microbiological and a functional proteomic point of view. We focused on the shaping of the mouse gut microbiota in dependence on the feeding modality, defining a reliable taxonomic description, highlighting some functional characteristics of the microbial community, and performing a first quantitative evaluation by data independent analysis in metaproteomics.
    Keywords animal models ; biochemical pathways ; bioinformatics ; breast feeding ; functional properties ; gene expression regulation ; genetic background ; immune system ; intestinal microorganisms ; liquid chromatography ; maternal milk ; mice ; microbial communities ; neonates ; peptides ; proteins ; proteome ; proteomics ; quantitative analysis ; reference works ; tandem mass spectrometry ; taxon descriptions
    Language English
    Dates of publication 2019-0715
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2400835-7
    ISSN 1876-7737 ; 1874-3919
    ISSN (online) 1876-7737
    ISSN 1874-3919
    DOI 10.1016/j.jprot.2019.103378
    Database NAL-Catalogue (AGRICOLA)

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