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  1. Article ; Online: Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin.

    Sun, Hongzhe / Zhang, Qi / Wang, Runming / Wang, Haibo / Wong, Yuen-Ting / Wang, Minji / Hao, Quan / Yan, Aixin / Kao, Richard Yi-Tsun / Ho, Pak-Leung / Li, Hongyan

    Nature communications

    2020  Volume 11, Issue 1, Page(s) 5263

    Abstract: Global emergence of Gram-negative bacteria carrying the plasmid-borne resistance genes, bla ...

    Abstract Global emergence of Gram-negative bacteria carrying the plasmid-borne resistance genes, bla
    MeSH term(s) Animals ; Anti-Bacterial Agents/administration & dosage ; Auranofin/administration & dosage ; Carbapenems/pharmacology ; Colistin/pharmacology ; Drug Resistance, Multiple, Bacterial ; Escherichia coli/drug effects ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/microbiology ; Escherichia coli Proteins/antagonists & inhibitors ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Microbial Sensitivity Tests ; beta-Lactamase Inhibitors/administration & dosage ; beta-Lactamases/genetics ; beta-Lactamases/metabolism
    Chemical Substances Anti-Bacterial Agents ; Carbapenems ; Escherichia coli Proteins ; beta-Lactamase Inhibitors ; Auranofin (3H04W2810V) ; beta-Lactamases (EC 3.5.2.6) ; Colistin (Z67X93HJG1)
    Keywords covid19
    Language English
    Publishing date 2020-10-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-020-18939-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin

    Hongzhe Sun / Qi Zhang / Runming Wang / Haibo Wang / Yuen-Ting Wong / Minji Wang / Quan Hao / Aixin Yan / Richard Yi-Tsun Kao / Pak-Leung Ho / Hongyan Li

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 13

    Abstract: ... antibiotic resistance to carbapenem and colistin. ... Multi-drug resistant pathogens remain a serious public health threat. Here, Sun and colleagues ... identify a role for auranofin, which is normally used as a drug for rheumatoid arthritis, for reversing ...

    Abstract Multi-drug resistant pathogens remain a serious public health threat. Here, Sun and colleagues identify a role for auranofin, which is normally used as a drug for rheumatoid arthritis, for reversing antibiotic resistance to carbapenem and colistin.
    Keywords Science ; Q
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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