Article ; Online: Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome.
JACC. Basic to translational science
2018 Volume 3, Issue 2, Page(s) 213–226
Abstract: ... nitric oxide signaling, and post-mortem studies of TS heart samples revealed nitrosative stress ... evidence of nitrosative stress, and consequent activation of the energy-depleting enzyme poly(ADP-ribose ... Therefore, we first showed in a female rat model that isoproterenol induces TS-like echocardiographic changes ...
| Abstract | Previous studies have shown that patients with Takotsubo syndrome (TS) have supranormal nitric oxide signaling, and post-mortem studies of TS heart samples revealed nitrosative stress. Therefore, we first showed in a female rat model that isoproterenol induces TS-like echocardiographic changes, evidence of nitrosative stress, and consequent activation of the energy-depleting enzyme poly(ADP-ribose) polymerase-1. We subsequently showed that pre-treatment with an inhibitor of poly(ADP-ribose) polymerase-1 ameliorated contractile abnormalities. These findings thus add to previous reports of aberrant β-adrenoceptor signaling (coupled with nitric oxide synthase activation) to elucidate mechanisms of impaired cardiac function in TS and point to potential methods of treatment. |
|---|---|
| Language | English |
| Publishing date | 2018-04-18 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 2452-302X |
| ISSN (online) | 2452-302X |
| DOI | 10.1016/j.jacbts.2017.10.002 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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