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  1. Article ; Online: Expression of the TRPM6 in mouse placental trophoblasts; potential role in maternal-fetal calcium transport.

    Suzuki, Yoshiro / Watanabe, Masaki / Saito, Claire T / Tominaga, Makoto

    The journal of physiological sciences : JPS

    2016  Volume 67, Issue 1, Page(s) 151–162

    Abstract: The placenta is required to transport calcium (Ca ...

    Abstract The placenta is required to transport calcium (Ca
    MeSH term(s) Animals ; Calcium/metabolism ; Cell Membrane Permeability/physiology ; Female ; HEK293 Cells ; Humans ; Ion Transport/physiology ; Maternal-Fetal Exchange/physiology ; Mice ; Placenta/metabolism ; Pregnancy ; TRPM Cation Channels/genetics ; TRPM Cation Channels/metabolism ; Trophoblasts/metabolism
    Chemical Substances TRPM Cation Channels ; Trpm6 protein, mouse ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2016-04-04
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2234472-X
    ISSN 1880-6562 ; 1880-6546
    ISSN (online) 1880-6562
    ISSN 1880-6546
    DOI 10.1007/s12576-016-0449-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Mapping the expression of transient receptor potential channels across murine placental development.

    De Clercq, Katrien / Pérez-García, Vicente / Van Bree, Rieta / Pollastro, Federica / Peeraer, Karen / Voets, Thomas / Vriens, Joris

    Cellular and molecular life sciences : CMLS

    2021  Volume 78, Issue 11, Page(s) 4993–5014

    Abstract: ... TRP channels have been shown to contribute to maternal-fetal transport of magnesium and calcium ... E10.5-E18.5) was assessed. Prominent expression was observed for Trpv2, Trpm6, and Trpm7. Calcium ... the functional activity of TRPV2 and TRPM7. Finally, comparing TRP channels expression in mouse trophoblast stem cells ...

    Abstract Transient receptor potential (TRP) channels play prominent roles in ion homeostasis by their ability to control cation influx. Mouse placentation is governed by the processes of trophoblast proliferation, invasion, differentiation, and fusion, all of which require calcium signaling. Although certain TRP channels have been shown to contribute to maternal-fetal transport of magnesium and calcium, a role for TRP channels in specific trophoblast functions has been disregarded. Using qRT-PCR and in situ hybridisation, the spatio-temporal expression pattern of TRP channels in the mouse placenta across gestation (E10.5-E18.5) was assessed. Prominent expression was observed for Trpv2, Trpm6, and Trpm7. Calcium microfluorimetry in primary trophoblast cells isolated at E14.5 of gestation further revealed the functional activity of TRPV2 and TRPM7. Finally, comparing TRP channels expression in mouse trophoblast stem cells (mTSCs) and mouse embryonic stem cells (mESC) confirmed the specific expression of TRPV2 during placental development. Moreover, TRP channel expression was similar in mTSCs compared to primary trophoblasts and validate mTSC as a model to study TRP channels in placental development. Collectivity, our results identify a specific spatio-temporal TRP channel expression pattern in trophoblasts, suggesting a possible involvement in regulating the process of placentation.
    MeSH term(s) Animals ; Calcium Channels/genetics ; Calcium Channels/metabolism ; Calcium Signaling ; Cell Differentiation ; Cell Proliferation ; Female ; Gene Expression Regulation ; Mice ; Mice, Inbred C57BL ; Mouse Embryonic Stem Cells/cytology ; Mouse Embryonic Stem Cells/metabolism ; Placenta/metabolism ; Placentation/genetics ; Pregnancy ; Stem Cells/cytology ; Stem Cells/metabolism ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism ; Transient Receptor Potential Channels/genetics ; Transient Receptor Potential Channels/metabolism ; Trophoblasts/cytology ; Trophoblasts/metabolism
    Chemical Substances Calcium Channels ; TRPV Cation Channels ; Transient Receptor Potential Channels ; Trpv2 protein, mouse
    Language English
    Publishing date 2021-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-021-03837-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 195: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Mapping the expression of transient receptor potential channels across murine placental development

    De Clercq, Katrien / Pérez-García, Vicente / Van Bree, Rieta / Pollastro, Federica / Peeraer, Karen / Voets, Thomas / Vriens, Joris

    Cellular and molecular life sciences. 2021 June, v. 78, no. 11

    2021  

    Abstract: ... TRP channels have been shown to contribute to maternal–fetal transport of magnesium and calcium ... E10.5–E18.5) was assessed. Prominent expression was observed for Trpv2, Trpm6, and Trpm7. Calcium ... the functional activity of TRPV2 and TRPM7. Finally, comparing TRP channels expression in mouse trophoblast stem cells ...

    Abstract Transient receptor potential (TRP) channels play prominent roles in ion homeostasis by their ability to control cation influx. Mouse placentation is governed by the processes of trophoblast proliferation, invasion, differentiation, and fusion, all of which require calcium signaling. Although certain TRP channels have been shown to contribute to maternal–fetal transport of magnesium and calcium, a role for TRP channels in specific trophoblast functions has been disregarded. Using qRT-PCR and in situ hybridisation, the spatio-temporal expression pattern of TRP channels in the mouse placenta across gestation (E10.5–E18.5) was assessed. Prominent expression was observed for Trpv2, Trpm6, and Trpm7. Calcium microfluorimetry in primary trophoblast cells isolated at E14.5 of gestation further revealed the functional activity of TRPV2 and TRPM7. Finally, comparing TRP channels expression in mouse trophoblast stem cells (mTSCs) and mouse embryonic stem cells (mESC) confirmed the specific expression of TRPV2 during placental development. Moreover, TRP channel expression was similar in mTSCs compared to primary trophoblasts and validate mTSC as a model to study TRP channels in placental development. Collectivity, our results identify a specific spatio-temporal TRP channel expression pattern in trophoblasts, suggesting a possible involvement in regulating the process of placentation.
    Keywords calcium ; cations ; homeostasis ; hybridization ; magnesium ; mice ; pregnancy ; transient receptor potential vanilloid channels ; trophoblast
    Language English
    Dates of publication 2021-06
    Size p. 4993-5014.
    Publishing place Springer International Publishing
    Document type Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-021-03837-3
    Database NAL-Catalogue (AGRICOLA)

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