Article ; Online: Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics.
Current opinion in pharmacology
2013 Volume 15, Page(s) 7–15
Abstract: Inward rectifier potassium (Kir) channels play fundamental roles in cardiac and renal function and ... channels has slowed progress toward exploring their integrative physiology and therapeutic potential. Here ... we review recent progress toward developing the small-molecule pharmacology for Kir2.x, Kir4.1, and Kir7.1 ...
| Abstract | Inward rectifier potassium (Kir) channels play fundamental roles in cardiac and renal function and may represent unexploited drug targets for cardiovascular diseases. However, the limited pharmacology of Kir channels has slowed progress toward exploring their integrative physiology and therapeutic potential. Here, we review recent progress toward developing the small-molecule pharmacology for Kir2.x, Kir4.1, and Kir7.1 and discuss common mechanistic themes that may help guide future Kir channel-directed drug discovery efforts. |
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| MeSH term(s) | Animals ; Heart Diseases/drug therapy ; Heart Diseases/metabolism ; Humans ; Kidney Diseases/drug therapy ; Kidney Diseases/metabolism ; Models, Molecular ; Potassium Channels, Inwardly Rectifying/agonists ; Potassium Channels, Inwardly Rectifying/antagonists & inhibitors ; Potassium Channels, Inwardly Rectifying/chemistry ; Potassium Channels, Inwardly Rectifying/metabolism | |||||
| Chemical Substances | Potassium Channels, Inwardly Rectifying | |||||
| Language | English | |||||
| Publishing date | 2013-11-26 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Review | |||||
| ZDB-ID | 2037057-X | |||||
| ISSN | 1471-4973 ; 1471-4892 | |||||
| ISSN (online) | 1471-4973 | |||||
| ISSN | 1471-4892 | |||||
| DOI | 10.1016/j.coph.2013.11.002 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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