Article ; Online: Heparin - Messias or Verschlimmbesserung?
Journal of thrombosis and haemostasis : JTH
2021 Volume 19, Issue 10, Page(s) 2373–2382
Abstract: ... coronavirus 2 infection led to the widespread use of heparin anticoagulation in the coronavirus disease 2019 ... of heparin to prevent thrombotic events was observed in hospitalized patients with this viral infection ... In this review, we explore the likely mechanisms for heparin failure with particular relevance to COVID-19 ...
| Abstract | A heightened risk of thrombosis noted early on with the severe acute respiratory syndrome coronavirus 2 infection led to the widespread use of heparin anticoagulation in the coronavirus disease 2019 (COVID-19) pandemic. However, reports soon started appearing in the literature where an apparent failure of heparin to prevent thrombotic events was observed in hospitalized patients with this viral infection. In this review, we explore the likely mechanisms for heparin failure with particular relevance to COVID-19. We also explore the role of anti-Xa assays and global hemostatic tests in this context. The current controversy of dosing heparin in this disease is detailed with some possible mechanistic reasons for anticoagulant failure. We hope that lessons learnt from the use of heparin in COVID-19 could assist us in the appropriate use of this anticoagulant in the future. |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| MeSH term(s) | Anticoagulants/adverse effects ; COVID-19 ; Heparin/adverse effects ; Humans ; Pandemics ; SARS-CoV-2 | ||||||||||
| Chemical Substances | Anticoagulants ; Heparin (9005-49-6) | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2021-07-29 | ||||||||||
| Publishing country | England | ||||||||||
| Document type | Journal Article ; Review | ||||||||||
| ZDB-ID | 2112661-6 | ||||||||||
| ISSN | 1538-7836 ; 1538-7933 | ||||||||||
| ISSN (online) | 1538-7836 | ||||||||||
| ISSN | 1538-7933 | ||||||||||
| DOI | 10.1111/jth.15464 | ||||||||||
| Shelf mark |
|
||||||||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 5805: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
|||
| Zs.MO 295: Show issues |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.