Article ; Online: Clinical and immunologic implications of COVID-19 in patients with melanoma and renal cell carcinoma receiving immune checkpoint inhibitors.
Journal for immunotherapy of cancer
2021 Volume 9, Issue 7
Abstract: ... with a focus on patients with melanoma and renal cell carcinoma (RCC). More specifically, we summarize ... the use of immune checkpoint inhibitors (ICIs) in patients with cancer during the SARS-CoV-2 pandemic ... The clinical and immunologic implications of the SARS-CoV-2 pandemic for patients with cancer ...
| Abstract | The clinical and immunologic implications of the SARS-CoV-2 pandemic for patients with cancer receiving systemic anticancer therapy have introduced a multitude of clinical challenges and academic controversies. This review summarizes the current evidence, discussion points, and recommendations regarding the use of immune checkpoint inhibitors (ICIs) in patients with cancer during the SARS-CoV-2 pandemic, with a focus on patients with melanoma and renal cell carcinoma (RCC). More specifically, we summarize the theoretical concepts and available objective data regarding the relationships between ICIs and the antiviral immune response, along with recommended clinical approaches to the management of melanoma and RCC patient cohorts receiving ICIs throughout the course of the COVID-19 pandemic. Additional insights regarding the use of ICIs in the setting of current and upcoming COVID-19 vaccines and broader implications toward future pandemics are also discussed. |
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| MeSH term(s) | COVID-19/epidemiology ; COVID-19/immunology ; COVID-19 Vaccines/immunology ; COVID-19 Vaccines/therapeutic use ; Carcinoma, Renal Cell/immunology ; Carcinoma, Renal Cell/therapy ; Humans ; Immune Checkpoint Inhibitors/immunology ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy/methods ; Kidney Neoplasms/immunology ; Kidney Neoplasms/therapy ; Melanoma/immunology ; Melanoma/therapy ; Pandemics/prevention & control ; SARS-CoV-2/drug effects ; SARS-CoV-2/immunology ; COVID-19 Drug Treatment |
| Chemical Substances | COVID-19 Vaccines ; Immune Checkpoint Inhibitors |
| Language | English |
| Publishing date | 2021-07-16 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 2719863-7 |
| ISSN | 2051-1426 ; 2051-1426 |
| ISSN (online) | 2051-1426 |
| ISSN | 2051-1426 |
| DOI | 10.1136/jitc-2021-002835 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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