Article ; Online: PRINS, a primate-specific long non-coding RNA, plays a role in the keratinocyte stress response and psoriasis pathogenesis.
Pflugers Archiv : European journal of physiology
2016 Volume 468, Issue 6, Page(s) 935–943
Abstract: ... in keratinocyte stress response. Elevated levels of PRINS expression in psoriatic non-lesional keratinocytes alter ... the stress response of non-lesional epidermis and contribute to disease pathogenesis. Finally, we propose ... Results gathered for PRINS in the last 10 years indicate that it is conserved in primates and plays a role ...
| Abstract | In the last few years with the recent emergence of high-throughput technologies, thousands of long non-coding RNAs (lncRNAs) have been identified in the human genome. However, assigning functional annotation and determining cellular contexts for these RNAs are still in its infancy. As information gained about lncRNA structure, interacting partners, and roles in human diseases may be helpful in the characterization of novel lncRNAs, we review our knowledge on a selected group of lncRNAs that were identified serendipitously years ago by large-scale gene expression methods used to study human diseases. In particular, we focus on the Psoriasis-susceptibility-Related RNA Gene Induced by Stress (PRINS) lncRNA, first identified by our research group as a transcript highest expressed in psoriatic non-lesional epidermis. Results gathered for PRINS in the last 10 years indicate that it is conserved in primates and plays a role in keratinocyte stress response. Elevated levels of PRINS expression in psoriatic non-lesional keratinocytes alter the stress response of non-lesional epidermis and contribute to disease pathogenesis. Finally, we propose a categorization for the PRINS lncRNA based on a recently elaborated system for lncRNA classification. |
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| MeSH term(s) | Animals ; Humans ; Keratinocytes/metabolism ; Keratinocytes/pathology ; Primates ; Psoriasis/etiology ; Psoriasis/genetics ; Psoriasis/metabolism ; RNA, Long Noncoding/classification ; RNA, Long Noncoding/genetics ; Stress, Physiological/genetics | |||||
| Chemical Substances | PRINS RNA, human ; RNA, Long Noncoding | |||||
| Language | English | |||||
| Publishing date | 2016-06 | |||||
| Publishing country | Germany | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 6380-0 | |||||
| ISSN | 1432-2013 ; 0031-6768 | |||||
| ISSN (online) | 1432-2013 | |||||
| ISSN | 0031-6768 | |||||
| DOI | 10.1007/s00424-016-1803-z | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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