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  1. Article ; Online: Quantitative Anatomy of the Growing Lungs in the Human Fetus.

    Szpinda, Michał / Siedlaczek, Waldemar / Szpinda, Anna / Woźniak, Alina / Mila-Kierzenkowska, Celestyna / Badura, Mateusz

    BioMed research international

    2015  Volume 2015, Page(s) 362781

    Abstract: ... of the lungs in 67 human fetuses aged 16-25 weeks. The lung dimensions revealed no sex differences ... in the fetus are relevant in the evaluation of the normative pulmonary growth and the diagnosis of pulmonary ... 17 to 1.48 ± 0.22 in the left lung. In the fetal lungs, their proportionate increase in transverse ...

    Abstract Using anatomical, digital, and statistical methods we examined the three-dimensional growth of the lungs in 67 human fetuses aged 16-25 weeks. The lung dimensions revealed no sex differences. The transverse and sagittal diameters and the base circumference were greater in the right lungs while the lengths of anterior and posterior margins and the lung height were greater in the left lungs. The best-fit curves for all the lung parameters were natural logarithmic models. The transverse-to-sagittal diameter ratio remained stable and averaged 0.56 ± 0.08 and 0.52 ± 0.08 for the right and left lungs, respectively. For the right and left lungs, the transverse diameter-to-height ratio significantly increased from 0.74 ± 0.09 to 0.92 ± 0.08 and from 0.56 ± 0.07 to 0.79 ± 0.09, respectively. The sagittal diameter-to-height ratio significantly increased from 1.41 ± 0.23 to 1.66 ± 0.18 in the right lung, and from 1.27 ± 0.17 to 1.48 ± 0.22 in the left lung. In the fetal lungs, their proportionate increase in transverse and sagittal diameters considerably accelerates with relation to the lung height. The lung dimensions in the fetus are relevant in the evaluation of the normative pulmonary growth and the diagnosis of pulmonary hypoplasia.
    MeSH term(s) Female ; Fetal Development/physiology ; Fetus/anatomy & histology ; Gestational Age ; Humans ; Lung/anatomy & histology ; Lung/growth & development ; Male ; Organogenesis/physiology ; Pregnancy
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2015/362781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Quantitative Anatomy of the Growing Lungs in the Human Fetus

    Michał Szpinda / Waldemar Siedlaczek / Anna Szpinda / Alina Woźniak / Celestyna Mila-Kierzenkowska / Mateusz Badura

    BioMed Research International, Vol

    2015  Volume 2015

    Abstract: ... of the lungs in 67 human fetuses aged 16–25 weeks. The lung dimensions revealed no sex differences ... in the left lung. In the fetal lungs, their proportionate increase in transverse and sagittal diameters ... considerably accelerates with relation to the lung height. The lung dimensions in the fetus are relevant ...

    Abstract Using anatomical, digital, and statistical methods we examined the three-dimensional growth of the lungs in 67 human fetuses aged 16–25 weeks. The lung dimensions revealed no sex differences. The transverse and sagittal diameters and the base circumference were greater in the right lungs while the lengths of anterior and posterior margins and the lung height were greater in the left lungs. The best-fit curves for all the lung parameters were natural logarithmic models. The transverse-to-sagittal diameter ratio remained stable and averaged 0.56±0.08 and 0.52±0.08 for the right and left lungs, respectively. For the right and left lungs, the transverse diameter-to-height ratio significantly increased from 0.74±0.09 to 0.92±0.08 and from 0.56±0.07 to 0.79±0.09, respectively. The sagittal diameter-to-height ratio significantly increased from 1.41±0.23 to 1.66±0.18 in the right lung, and from 1.27±0.17 to 1.48±0.22 in the left lung. In the fetal lungs, their proportionate increase in transverse and sagittal diameters considerably accelerates with relation to the lung height. The lung dimensions in the fetus are relevant in the evaluation of the normative pulmonary growth and the diagnosis of pulmonary hypoplasia.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Quantitative aspects of perinatal lung growth.

    Wigglesworth, J S / Desai, R / Aber, V

    Early human development

    1987  Volume 15, Issue 4, Page(s) 203–212

    Abstract: ... with an advance in lung maturation, while the increased hydroxyproline concentration in the lungs of cases of HMD ... investigated in lungs of 97 normally formed infants over an age range from 22 to 75 postconceptional weeks ... of hydroxyproline and showed a peak DSPC concentration at an earlier gestation than the normals. Lungs of HMD ...

    Abstract Weight, DNA, protein, hydroxyproline and disaturated phosphatidylcholine (DSPC) content were investigated in lungs of 97 normally formed infants over an age range from 22 to 75 postconceptional weeks, including 25 cases of hyaline membrane disease (HMD) and 13 small-for-dates infants (SFD). Lung weight and lung DNA relative to body weight were markedly lower in infants who died at 37-41 weeks than in those who died at shorter gestations or in early infancy. Total lung DSPC and DSPC concentration had a narrow peak at 36-41 weeks. The DSPC concentration per milligram of lung DNA in the first few months of infant life was similar to that in infants at 24 weeks gestation. Lung protein concentrations increased steadily but were variable at all ages. SFD infants had significantly higher concentrations of hydroxyproline and showed a peak DSPC concentration at an earlier gestation than the normals. Lungs of HMD infants showed some increase in hydroxyproline concentration but little other quantitative evidence of difference from the normals. We suggest that the relatively small lung size in many infants who die near term may result from recurrent intrauterine stress. Lung changes in small for dates infants are compatible with an advance in lung maturation, while the increased hydroxyproline concentration in the lungs of cases of HMD implies an early proliferative response to lung injury.
    MeSH term(s) DNA/metabolism ; Embryonic and Fetal Development ; Gestational Age ; Humans ; Hyaline Membrane Disease/metabolism ; Hydroxyproline/metabolism ; Infant ; Infant, Newborn/growth & development ; Infant, Newborn/metabolism ; Lung/anatomy & histology ; Lung/growth & development ; Lung/metabolism ; Organ Size ; Proteins/metabolism ; Pulmonary Surfactants/metabolism
    Chemical Substances Proteins ; Pulmonary Surfactants ; DNA (9007-49-2) ; Hydroxyproline (RMB44WO89X)
    Language English
    Publishing date 1987-07
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752532-1
    ISSN 1872-6232 ; 0378-3782
    ISSN (online) 1872-6232
    ISSN 0378-3782
    DOI 10.1016/0378-3782(87)90078-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1373: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article: Small-granule APUD cells in relation to airway branching and growth: a quantitative, cartographic study in Syrian golden hamsters.

    Sarikas, S N / Hoyt, R F / Sorokin, S P

    The Anatomical record

    1985  Volume 213, Issue 3, Page(s) 410–420

    Abstract: ... clusters decreased between 13 and 14 days but more than doubled by day 15. Unlike human lungs ... and 15-day fetal hamster lungs. Every sixth section was drawn from a camera lucida projection ... A preliminary survey of the entire left and right lungs showed that the pattern of airway and small-granule cell ...

    Abstract Small-granule APUD cell clusters and their clear-cell precursors were mapped in serial 2-micron glycol methacrylate-embedded, periodic acid-Schiff (PAS)-lead hematoxylin-stained sections of 13-, 14-, and 15-day fetal hamster lungs. Every sixth section was drawn from a camera lucida projection on tracing paper. Each tracing included the profiles of nonalveolated air passages and the locations of small-granule cell clusters and solitary clear cells. Airways containing ciliated cells and those surrounded by condensed mesoderm were also labeled. Single clear cells were rare in fetal hamster lung. Of 2,368 endocrine cell loci identified in the three fetal age groups examined, only 14 were single clear cells. A preliminary survey of the entire left and right lungs showed that the pattern of airway and small-granule cell development in the infracardiac lobe was similar to that occurring in the remainder of the lung; this lobe was accordingly considered a model for the whole lung, and the ontogeny of its small-granule cell population was quantitated and compared with results of similar quantitative mapping of this lobe in an adult animal (Hoyt et al., 1982a,b). Along the lobar bronchus of the 13-day infracardiac lobe and proximal portions of its main branches, small-granule cell clusters occurred most often near airway intersections. As the number and density increased in subsequent fetal stages, small-granule cell clusters became conspicuous along internodal bronchial segments. In distributing bronchioles, the population density of small-granule cell clusters decreased between 13 and 14 days but more than doubled by day 15. Unlike human lungs, where centrifugally developing small-granule cell clusters are firmly established in terminal bronchioles well before birth, most peripheral bronchioles in fetal hamster were devoid of small-granule cell clusters, even at 15 days, one day before birth. Comparison of numerical population densities in this lobe of fetal and adult lungs indicates that small-granule cell clusters continue to form past day 15 and suggests that they are considerably more numerous in adult than fetal lung.
    MeSH term(s) APUD Cells/cytology ; APUD Cells/ultrastructure ; Animals ; Bronchi/cytology ; Bronchi/embryology ; Cell Count ; Cricetinae ; Cytoplasmic Granules/ultrastructure ; Female ; Fetus/analysis ; Lung/cytology ; Lung/embryology ; Lung/ultrastructure ; Mesocricetus ; Pregnancy ; Pulmonary Alveoli/cytology ; Pulmonary Alveoli/embryology
    Language English
    Publishing date 1985-11
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 203685-x
    ISSN 0003-276X
    ISSN 0003-276X
    DOI 10.1002/ar.1092130307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.65: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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