Article ; Online: ABO blood type association with SARS-CoV-2 infection mortality: A single-center population in New York City.
2021 Volume 61, Issue 4, Page(s) 1064–1070
Abstract: ... course with significant mortality. Early reports suggested higher rates of SARS-CoV-2 infection ... this association may reveal insights into the susceptibility and/or immunity to SARS-CoV-2. ... 003).: Conclusions: Our study shows that ABO histo-blood group type is associated with the risk ...
| Abstract | Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a variable clinical course with significant mortality. Early reports suggested higher rates of SARS-CoV-2 infection in patients with type A blood and enrichment of type A individuals among COVID-19 mortalities. Study design and methods: The study includes all patients hospitalized or with an emergency department (ED) visit who were tested for SARS-CoV-2 between March 10, 2020 and June 8, 2020 and had a positive test result by nucleic acid test (NAT) performed on a nasopharyngeal swab specimen. A total of 4968 patients met the study inclusion criteria, with a subsequent 23.1% (n = 1146/4968) all-cause mortality rate in the study cohort. To estimate overall risk by ABO type and account for the competing risks of in-hospital mortality and discharge, we calculated the cumulative incidence function (CIF) for each event. Cause-specific hazard ratios (csHRs) for in-hospital mortality and discharge were analyzed using multivariable Cox proportional hazards models. Results: Type A blood was associated with the increased cause-specific hazard of death among COVID-19 patients compared to type O (HR = 1.17, 1.02-1.33, p = .02) and type B (HR = 1.32,1.10-1.58, p = .003). Conclusions: Our study shows that ABO histo-blood group type is associated with the risk of in-hospital death in COVID-19 patients, warranting additional inquiry. Elucidating the mechanism behind this association may reveal insights into the susceptibility and/or immunity to SARS-CoV-2. |
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| MeSH term(s) | ABO Blood-Group System ; Aged ; Aged, 80 and over ; COVID-19/blood ; COVID-19/mortality ; COVID-19/therapy ; Disease-Free Survival ; Female ; Hospital Mortality ; Hospitals ; Humans ; Incidence ; Male ; Middle Aged ; New York City/epidemiology ; Retrospective Studies ; SARS-CoV-2/metabolism ; Survival Rate | |||||
| Chemical Substances | ABO Blood-Group System | |||||
| Language | English | |||||
| Publishing date | 2021-03-05 | |||||
| Publishing country | United States | |||||
| Document type | Clinical Trial ; Journal Article | |||||
| ZDB-ID | 208417-x | |||||
| ISSN | 1537-2995 ; 0041-1132 | |||||
| ISSN (online) | 1537-2995 | |||||
| ISSN | 0041-1132 | |||||
| DOI | 10.1111/trf.16339 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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