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  1. Article ; Online: Cytokine profiling in Iranian patients with COVID-19; association with clinical severity.

    Taghiloo, Saeid / Soltanshahi, Mohsen / Aliyali, Masoud / Abedi, Siavash / Mehravaran, Hossein / Ajami, Abolghasem / Asgarian-Omran, Hossein

    Iranian journal of immunology : IJI

    2021  Volume 18, Issue 1, Page(s) 54–64

    Abstract: ... cytokines in COVID-19 patients with different clinical severity.: Methods: Concentrations of serum ... of these cytokines and clinical severity, CRP level, neutrophil and lymphocyte count in patients with COVID-19 ... to death in COVID-19 patients.: Objective: To investigate and compare the serum levels of different ...

    Abstract Background: SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is recognized for the first time in Wuhan, China. The cytokine storm is a known factor causing major clinical symptoms leading to death in COVID-19 patients.
    Objective: To investigate and compare the serum levels of different cytokines in COVID-19 patients with different clinical severity.
    Methods: Concentrations of serum cytokines, including IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α, IFN-γ, and GM-CSF, were measured in 61 COVID-19 patients and 31 normal controls with ELISA. We investigated the correlation between the levels of these cytokines and clinical severity, CRP level, neutrophil and lymphocyte count in patients with COVID-19.
    Results: Our data indicated that the levels of IL-1β, IL-2, IL-4, IL-6, IL-8, TNF-α, IFN-γ, and GM-CSF, but not IL-10 were significantly increased in COVID-19 patients compared to normal controls. Statistical analysis showed that the level of IL-1β, IL-2, IL-4, IL-6, IL-8, TNF-α, IFN-γ, and GM-CSF were higher in severe COVID-19 than those of mild cases. The concentrations of all mentioned cytokines were negatively associated with the absolute count of lymphocytes, and positively correlated with the CRP level and the absolute count of neutrophils.
    Conclusion: The current study suggests that high levels of various cytokines correlate with the disease severity and immunopathogenesis of COVID-19.
    MeSH term(s) Aged ; Biomarkers/blood ; C-Reactive Protein/analysis ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19/virology ; Case-Control Studies ; Cytokine Release Syndrome/blood ; Cytokine Release Syndrome/diagnosis ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/virology ; Cytokines/blood ; Female ; Host-Pathogen Interactions ; Humans ; Iran ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Lymphocytes/virology ; Male ; Middle Aged ; Neutrophils/immunology ; Neutrophils/metabolism ; Neutrophils/virology ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Severity of Illness Index
    Chemical Substances Biomarkers ; Cytokines ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2021-05-04
    Publishing country Iran
    Document type Comparative Study ; Journal Article
    ISSN 1735-367X
    ISSN (online) 1735-367X
    DOI 10.22034/iji.2021.87630.1810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cytokine profiling in Iranian patients with COVID-19; association with clinical severity

    Saeid Taghiloo / Mohsen Soltanshahi / masoud aliyali / Siavash Abedi / Hossein Mehravaran / Abolghasem Ajami / Hossein Asgarian-Omran

    Iranian Journal of Immunology, Vol 18, Iss 1, Pp 54-

    2021  Volume 64

    Abstract: ... cytokines in COVID-19 patients with different clinical severity. Methods: Concentrations of serum cytokines ... of these cytokines and clinical severity, CRP level, neutrophil and lymphocyte count in patients with COVID-19 ... to death in COVID-19 patients. Objective: To investigate and compare the serum levels of different ...

    Abstract Background: SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is recognized for the first time in Wuhan, China. The cytokine storm is a known factor causing major clinical symptoms leading to death in COVID-19 patients. Objective: To investigate and compare the serum levels of different cytokines in COVID-19 patients with different clinical severity. Methods: Concentrations of serum cytokines, including IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α, IFN-γ, and GM-CSF, were measured in 61 COVID-19 patients and 31 normal controls with ELISA. We investigated the correlation between the levels of these cytokines and clinical severity, CRP level, neutrophil and lymphocyte count in patients with COVID-19. Results: Our data indicated that the levels of IL-1β, IL-2, IL-4, IL-6, IL-8, TNF-α, IFN-γ, and GM-CSF, but not IL-10 were significantly increased in COVID-19 patients compared to normal controls. Statistical analysis showed that the level of IL-1β, IL-2, IL-4, IL-6, IL-8, TNF-α, IFN-γ, and GM-CSF were higher in severe COVID-19 than those of mild cases. The concentrations of all mentioned cytokines were negatively associated with the absolute count of lymphocytes, and positively correlated with the CRP level and the absolute count of neutrophils. Conclusion: The current study suggests that high levels of various cytokines correlate with the disease severity and immunopathogenesis of COVID-19.
    Keywords covid-19 ; cytokine storm ; disease severity ; iran ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Shiraz University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Article ; Online: Cytokine Profiles Associated With Acute COVID-19 and Long COVID-19 Syndrome.

    Queiroz, Maria Alice Freitas / Neves, Pablo Fabiano Moura das / Lima, Sandra Souza / Lopes, Jeferson da Costa / Torres, Maria Karoliny da Silva / Vallinoto, Izaura Maria Vieira Cayres / Bichara, Carlos David Araújo / Dos Santos, Erika Ferreira / de Brito, Mioni Thieli Figueiredo Magalhães / da Silva, Andréa Luciana Soares / Leite, Mauro de Meira / da Costa, Flávia Póvoa / Viana, Maria de Nazaré do Socorro de Almeida / Rodrigues, Fabíola Brasil Barbosa / de Sarges, Kevin Matheus Lima / Cantanhede, Marcos Henrique Damasceno / da Silva, Rosilene / Bichara, Clea Nazaré Carneiro / van den Berg, Ana Virgínia Soares /
    Veríssimo, Adriana de Oliveira Lameira / Carvalho, Mayara da Silva / Henriques, Daniele Freitas / Dos Santos, Carla Pinheiro / Nunes, Juliana Abreu Lima / Costa, Iran Barros / Viana, Giselle Maria Rachid / Carneiro, Francisca Regina Oliveira / Palacios, Vera Regina da Cunha Menezes / Quaresma, Juarez Antonio Simões / Brasil-Costa, Igor / Dos Santos, Eduardo José Melo / Falcão, Luiz Fábio Magno / Vallinoto, Antonio Carlos Rosário

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 922422

    Abstract: ... This study evaluated the impact of these factors on patients with clinical presentations of COVID-19 ... had sequelae (long COVID syndrome). In the acute COVID-19 group, patients with the severe form had ... The duration and severity of COVID-19 are related to age, comorbidities, and cytokine synthesis ...

    Abstract The duration and severity of COVID-19 are related to age, comorbidities, and cytokine synthesis. This study evaluated the impact of these factors on patients with clinical presentations of COVID-19 in a Brazilian cohort. A total of 317 patients diagnosed with COVID-19 were included; cases were distributed according to clinical status as severe (n=91), moderate (n=56) and mild (n=170). Of these patients, 92 had acute COVID-19 at sample collection, 90 had already recovered from COVID-19 without sequelae, and 135 had sequelae (long COVID syndrome). In the acute COVID-19 group, patients with the severe form had higher IL-6 levels (p=0.0260). In the post-COVID-19 group, there was no significant difference in cytokine levels between groups with different clinical conditions. In the acute COVID-19 group, younger patients had higher levels of TNF-α, and patients without comorbidities had higher levels of TNF-α, IL-4 and IL-2 (p<0.05). In contrast, patients over age 60 with comorbidities had higher levels of IL-6. In the post-COVID-19 group, subjects with long COVID-19 had higher levels of IL-17 and IL-2 (p<0.05), and subjects without sequelae had higher levels of IL-10, IL-6 and IL- 4 (p<0.05). Our results suggest that advanced age, comorbidities and elevated serum IL-6 levels are associated with severe COVID-19 and are good markers to differentiate severe from mild cases. Furthermore, high serum levels of IL-17 and IL-2 and low levels of IL-4 and IL-10 appear to constitute a cytokine profile of long COVID-19, and these markers are potential targets for COVID-19 treatment and prevention strategies.
    MeSH term(s) Biomarkers ; COVID-19/complications ; COVID-19/drug therapy ; Cytokines ; Humans ; Interleukin-10 ; Interleukin-17 ; Interleukin-2 ; Interleukin-4 ; Interleukin-6 ; Middle Aged ; SARS-CoV-2 ; Tumor Necrosis Factor-alpha
    Chemical Substances Biomarkers ; Cytokines ; Interleukin-17 ; Interleukin-2 ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Interleukin-10 (130068-27-8) ; Interleukin-4 (207137-56-2)
    Language English
    Publishing date 2022-06-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.922422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Serum cytokine/chemokine profile and clinical/paraclinical data in COVID-19 deceased and recovered patients

    Bahman Aghcheli / Emad Behboudi / Alijan Tabarraei / Hadi Razavi Nikoo / Abdolhalim Rajabi / Abdolvahab Moradi / Britt Nakstad / Alireza Tahamtan

    European Journal of Inflammation, Vol

    2022  Volume 20

    Abstract: ... for the association of cytokine/chemokine levels with the clinical course and outcome of COVID-19. More studies are ... recovered patients in Iran. Methods: The severity of disease, clinical data, and routine laboratory and ... evaluated serum cytokine/chemokine profiles, and clinical and paraclinical data of COVID-19 deceased and ...

    Abstract Objectives: The induction of an intense immune response and cytokine storm is proposed to be central in the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The study evaluated serum cytokine/chemokine profiles, and clinical and paraclinical data of COVID-19 deceased and recovered patients in Iran. Methods: The severity of disease, clinical data, and routine laboratory and inflammatory cytokine/chemokine responses were retrospectively explored in 60 in-hospital patients in northern Iran. Characteristics of those who deceased ( n = 30) were compared to recovered ( n = 30), and associations with serum levels of potential disease regulating pro- and anti-inflammatory mediators were studied. Results: The serum levels of IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-17, IP-10, MIP1-α, MCP1, RANTES, and TNF-α were upregulated in all COVID-19 patients when compared to healthy and gender-matched individuals ( n = 30). Although with no significant difference between deceased and recovered cases, the serum levels of all cytokines/chemokines tended to be higher in the severely diseased non-surviving patients. Association analyses revealed that all cytokine/chemokine levels (except IL-10) significantly affect the disease outcome. Conclusion: This study provides more evidence for the association of cytokine/chemokine levels with the clinical course and outcome of COVID-19. More studies are needed to consider this measurement as an indicator of disease stage and strategy for treatment.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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