Article ; Online: Italian survey on managing immune checkpoint inhibitors in oncology during COVID-19 outbreak.
European journal of clinical investigation
2020 Volume 50, Issue 9, Page(s) e13315
Abstract: Background: During COVID-19 outbreak, oncological care has been reorganized. Patients with cancer ... an ICI only for the risk of infection. During COVID-19 outbreak, to reduce hospital visits, 55.8% and 30 ... of a potential interference between immune checkpoint inhibitors (ICIs) and SARS-CoV-2 pathogenesis.: Materials ...
| Abstract | Background: During COVID-19 outbreak, oncological care has been reorganized. Patients with cancer have been reported to experience a more severe COVID-19 syndrome; moreover, there are concerns of a potential interference between immune checkpoint inhibitors (ICIs) and SARS-CoV-2 pathogenesis. Materials and methods: Between 6 and 16 May 2020, a 22-item survey was sent to Italian physicians involved in administering ICIs. It aimed at exploring the perception about SARS-CoV-2-related risks in cancer patients receiving ICIs, and the attitudes towards their management. Results: The 104 respondents had a median age of 35.5 years, 58.7% were females and 71.2% worked in Northern Italy. 47.1% of respondents argued a synergism between ICIs and SARS-CoV-2 pathogenesis leading to worse outcomes, but 97.1% would not deny an ICI only for the risk of infection. During COVID-19 outbreak, to reduce hospital visits, 55.8% and 30.8% opted for the highest labelled dose of each ICI and/or, among different ICIs for the same indication, for the one with the longer interval between cycles, respectively. 53.8% of respondents suggested testing for SARS-CoV-2 every cancer patient candidate to ICIs. 71.2% declared to manage patients with onset of dyspnoea and cough as infected by SARS-CoV-2 until otherwise proven; however, 96.2% did not reduce the use of steroids to manage immune-related toxicities. The administration of ICIs in specific situations for different cancer types has not been drastically conditioned. Conclusions: These results highlight the uncertainties around the perception of a potential interference between ICIs and COVID-19, supporting the need of focused studies on this topic. |
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| MeSH term(s) | Adult ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/statistics & numerical data ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Disease Outbreaks/statistics & numerical data ; Female ; Humans ; Immunocompromised Host ; Immunologic Factors/administration & dosage ; Italy ; Male ; Medical Oncology/methods ; Middle Aged ; Neoplasms/drug therapy ; Neoplasms/epidemiology ; Neoplasms/immunology ; Outcome Assessment, Health Care ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Risk Assessment ; Surveys and Questionnaires |
| Chemical Substances | Immunologic Factors |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-07-05 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 186196-7 |
| ISSN | 1365-2362 ; 0014-2972 ; 0960-135X |
| ISSN (online) | 1365-2362 |
| ISSN | 0014-2972 ; 0960-135X |
| DOI | 10.1111/eci.13315 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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