Article ; Online: Inefficient Placental Virus Replication and Absence of Neonatal Cell-Specific Immunity Upon Sars-CoV-2 Infection During Pregnancy.
2021 Volume 12, Page(s) 698578
Abstract: ... complications. Yet, vertical transmission of the virus is rare and the possibility of placental SARS-CoV-2 infection as a prerequisite ... infections in an observational study of women infected with SARS-CoV-2 during pregnancy. Our placental ... Pregnant women have been carefully observed during the COVID-19 pandemic, as the pregnancy-specific ...
| Abstract | Pregnant women have been carefully observed during the COVID-19 pandemic, as the pregnancy-specific immune adaptation is known to increase the risk for infections. Recent evidence indicates that even though most pregnant have a mild or asymptomatic course, a severe course of COVID-19 and a higher risk of progression to diseases have also been described, along with a heightened risk for pregnancy complications. Yet, vertical transmission of the virus is rare and the possibility of placental SARS-CoV-2 infection as a prerequisite for vertical transmission requires further studies. We here assessed the severity of COVID-19 and onset of neonatal infections in an observational study of women infected with SARS-CoV-2 during pregnancy. Our placental analyses showed a paucity of SARS-CoV-2 viral expression |
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| MeSH term(s) | Adult ; COVID-19/immunology ; COVID-19/transmission ; Female ; Fetal Blood/immunology ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Middle Aged ; Placenta/immunology ; Placenta/virology ; Pregnancy ; Pregnancy Complications, Infectious/immunology ; SARS-CoV-2/immunology ; Virus Replication/physiology |
| Language | English |
| Publishing date | 2021-06-03 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2606827-8 |
| ISSN | 1664-3224 ; 1664-3224 |
| ISSN (online) | 1664-3224 |
| ISSN | 1664-3224 |
| DOI | 10.3389/fimmu.2021.698578 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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