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  1. Article ; Online: Characteristics and outcomes of older patients with coronavirus disease 2019 in Japan.

    Tanaka, Kenta / Zha, Ling / Kitamura, Tetsuhisa / Katayama, Yusuke / Takeuchi, Taro / Komukai, Sho / Hirayama, Atsushi / Shimazu, Takeshi / Sobue, Tomotaka

    Geriatrics & gerontology international

    2021  Volume 21, Issue 8, Page(s) 629–635

    Abstract: ... the epidemiological characteristics of older patients with coronavirus disease 2019 in Osaka Prefecture, Japan ... disease 2019 among older patients have not been fully evaluated in Japan.: Methods ... with coronavirus disease 2019.: Results: Older patients accounted for 21.5% (3192/14 846) of the registered ...

    Abstract Aim: The epidemiological characteristics, in-hospital treatments and outcomes of coronavirus disease 2019 among older patients have not been fully evaluated in Japan.
    Methods: In this retrospective observational study carried out in Osaka Prefecture, Japan, we enrolled patients aged ≥60 years with laboratory-confirmed coronavirus disease 2019 from January to November 2020. The main outcome was mortality during the observation period, based on the Infectious Diseases Control Law. Cox regression analysis was used to evaluate the association between epidemiological factors and mortality among older patients with coronavirus disease 2019.
    Results: Older patients accounted for 21.5% (3192/14 846) of the registered patients with coronavirus disease 2019. The number of patients according to age was as follows: 60-69 years, 1140 (35.7%); 70-79 years, 1058 (33.1%); 80-89 years, 749 (23.5%); and ≥90 years, 245 (7.7%). The proportion of deaths during the observation period was 8.5% (271/3192). The proportion of deaths increased with increasing age category (from 1.9% to 20.4%, P for trend <0.001). In multivariable Cox regression analysis, patients aged 70-79, 80-89 and ≥90 years had higher hazard ratios and 95% confidence intervals of death (2.62 [1.63-4.23], 5.99 [3.77-9.50] and 10.24 [6.03-17.40], respectively) than those aged 60-69 years. Factors such as male sex, presence of comorbidities, cluster cases in medical institutions and moderate/severe symptoms at diagnosis were also associated with mortality.
    Conclusions: This study shows the epidemiological characteristics of older patients with coronavirus disease 2019 in Osaka Prefecture, Japan. The proportion of deaths was 8.5% in total and increased with increasing age. Geriatr Gerontol Int 2021; 21: 629-635.
    MeSH term(s) Aged ; Aged, 80 and over ; COVID-19/diagnosis ; COVID-19/mortality ; COVID-19/therapy ; Comorbidity ; Female ; Humans ; Japan/epidemiology ; Male ; Middle Aged ; Pregnancy ; Retrospective Studies ; SARS-CoV-2 ; Survival Analysis
    Language English
    Publishing date 2021-06-09
    Publishing country Japan
    Document type Journal Article ; Observational Study
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.14207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5801: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Clinical characteristics and prognosis of immunosuppressed inpatients with COVID-19 in Japan.

    Nomoto, Hidetoshi / Suzuki, Setsuko / Asai, Yusuke / Hayakawa, Kayoko / Gatanaga, Hiroyuki / Terada, Mari / Suzuki, Kumiko / Ohtsu, Hiroshi / Toyoda, Ako / Ohmagari, Norio

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2021  Volume 28, Issue 2, Page(s) 224–231

    Abstract: ... characteristics and outcomes were compared according to the immunosuppressed states of the patients. The impact ... 5%, n = 120). Immunosuppressed patients were older and had a higher severity of illness at admission ... inpatients with coronavirus disease 2019 (COVID-19).: Methods: In this observational study, we utilized ...

    Abstract Introduction: We aimed to analyze the clinical characteristics and outcomes of immunosuppressed inpatients with coronavirus disease 2019 (COVID-19).
    Methods: In this observational study, we utilized a large nationwide registry of hospitalized patients with COVID-19 in Japan. Patients' baseline characteristics and outcomes were compared according to the immunosuppressed states of the patients. The impact of different therapeutic agents on the clinical courses of the patients was evaluated.
    Results: Data of 14,760 patients were included, and 887 (5.9%) were immunosuppressed. The immunosuppressed state of the patient resulted from solid tumor (43.3%, n = 384), chemotherapy within 3 months (15.6%, n = 138), collagen disease (16.9%, n = 150), use of immunosuppressive agents (16.0%, n = 142), and metastatic solid tumor (13.5%, n = 120). Immunosuppressed patients were older and had a higher severity of illness at admission and during hospitalization than non-immunosuppressed patients. The mortality rates for major diseases causing immunosuppression were as follows: solid tumor, 12.5% (48/384; P < 0.001; relative risk [RR], 3.41); metastatic solid tumor, 31.7% (38/120; P < 0.001; RR, 8.43); leukemia, 23.1% (9/39; P < 0.001; RR, 5.87); lymphoma, 33.3% (20/60; P < 0.001; RR, 8.63); and collagen disease, 15.3% (23/150; P < 0.001; RR 3.97). Underlying diseases with high mortality rates were not necessarily associated with high rates of invasive supportive care.
    Conclusions: The prognosis of immunosuppressed COVID-19 inpatients varied according to the different immunosuppressed states. Multiple factors, including the severity of the underlying diseases, might have affected their invasive supportive care indications.
    MeSH term(s) COVID-19 ; Hospitalization ; Humans ; Inpatients ; Japan/epidemiology ; Prognosis ; SARS-CoV-2
    Language English
    Publishing date 2021-10-28
    Publishing country Netherlands
    Document type Journal Article ; Observational Study
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2021.10.021
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5236: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Changes in the characteristics and outcomes of COVID-19 patients from the early pandemic to the delta variant epidemic: a nationwide population-based study.

    Miyashita, Koichi / Hozumi, Hironao / Furuhashi, Kazuki / Nakatani, Eiji / Inoue, Yusuke / Yasui, Hideki / Karayama, Masato / Suzuki, Yuzo / Fujisawa, Tomoyuki / Enomoto, Noriyuki / Inui, Naoki / Ojima, Toshiyuki / Suda, Takafumi

    Emerging microbes & infections

    2022  Volume 12, Issue 1, Page(s) 2155250

    Abstract: ... have a dynamic and complex effect on the characteristics and outcomes of patients. Therefore, there is ... inpatients in Japan to investigate the changes in their characteristics, outcomes and risk factors ... The coronavirus disease 2019 (COVID-19) pandemic has dramatically changed because of virus ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic has dramatically changed because of virus mutations, vaccine dissemination, treatment development and policies, among other factors. These factors have a dynamic and complex effect on the characteristics and outcomes of patients. Therefore, there is an urgent need to understand those changes and update the evidence. We used a large-scale real-world data set of 937,758 patients with COVID-19 from a nationwide claims database that included outpatients and inpatients in Japan to investigate the changes in their characteristics, outcomes and risk factors for severity/mortality from the early pandemic to the delta variant-predominant waves. The severity of COVID-19 was defined according to the modified World Health Organization clinical-progression ordinal scale. With changing waves, mean patient age decreased, and proportion of patients with comorbidities decreased. The incidences of "severe COVID-19 or death (i.e. ≥severe COVID-19)" and "death" markedly declined (5.0% and 2.9%, wild-type-predominant; 4.6% and 2.2%, alpha variant-predominant and 1.4% and 0.4%, delta variant-predominant waves, respectively). Across the wave shift, risk factors for ≥ severe COVID-19 and death, including older age, male, malignancy, congestive heart failure and chronic obstructive pulmonary disease, were largely consistent. The significance of some factors, such as liver disease, varied as per the wave. This study, one of the largest population-based studies on COVID-19, showed that patient characteristics and outcomes changed during the waves. Risk factors for severity/mortality were similar across all waves, but some factors were inconsistent. These data suggest that the clinical status of COVID-19 will change further with the coming epidemic wave.
    MeSH term(s) Humans ; Male ; Pandemics ; COVID-19/epidemiology ; SARS-CoV-2/genetics ; Inpatients
    Language English
    Publishing date 2022-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2022.2155250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Characteristics and Survival of Intensive Care Unit Patients with Coronavirus Disease in Osaka, Japan: A Retrospective Observational Study.

    Zha, Ling / Sobue, Tomotaka / Takeuchi, Taro / Tanaka, Kenta / Katayama, Yusuke / Komukai, Sho / Hirayama, Atsushi / Shimazu, Takeshi / Kitamura, Tetsuhisa / The Covid-Epidemiology Research Group Of Osaka University

    Journal of clinical medicine

    2021  Volume 10, Issue 11

    Abstract: The epidemiological and clinical characteristics, treatments, and outcomes of patients ... 5%) were men and 149 (72.7%) were older than 60 years. A total of 117 patients (57.1%) had ... with coronavirus disease 2019 (COVID-19) who are admitted to the intensive care unit (ICU) have not been adequately ...

    Abstract The epidemiological and clinical characteristics, treatments, and outcomes of patients with coronavirus disease 2019 (COVID-19) who are admitted to the intensive care unit (ICU) have not been adequately evaluated in Japan. We analyzed the registry data of 205 patients with COVID-19 admitted to the ICU between February and November 2020, in Osaka Prefecture, Japan. A Cox proportional hazards model was used to assess the association between epidemiological factors and mortality among ICU patients. Of the 205 ICU patients, 161 (78.5%) were men and 149 (72.7%) were older than 60 years. A total of 117 patients (57.1%) had comorbidities. The most common symptoms at diagnosis were mild (
    Language English
    Publishing date 2021-06-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10112477
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  5. Article ; Online: Characteristics and Survival of Intensive Care Unit Patients with Coronavirus Disease in Osaka, Japan

    Ling Zha / Tomotaka Sobue / Taro Takeuchi / Kenta Tanaka / Yusuke Katayama / Sho Komukai / Atsushi Hirayama / Takeshi Shimazu / Tetsuhisa Kitamura / the COVID-19 Epidemiology Research Group of Osaka University

    Journal of Clinical Medicine, Vol 10, Iss 2477, p

    A Retrospective Observational Study

    2021  Volume 2477

    Abstract: The epidemiological and clinical characteristics, treatments, and outcomes of patients ... 5%) were men and 149 (72.7%) were older than 60 years. A total of 117 patients (57.1%) had ... with coronavirus disease 2019 (COVID-19) who are admitted to the intensive care unit (ICU) have not been adequately ...

    Abstract The epidemiological and clinical characteristics, treatments, and outcomes of patients with coronavirus disease 2019 (COVID-19) who are admitted to the intensive care unit (ICU) have not been adequately evaluated in Japan. We analyzed the registry data of 205 patients with COVID-19 admitted to the ICU between February and November 2020, in Osaka Prefecture, Japan. A Cox proportional hazards model was used to assess the association between epidemiological factors and mortality among ICU patients. Of the 205 ICU patients, 161 (78.5%) were men and 149 (72.7%) were older than 60 years. A total of 117 patients (57.1%) had comorbidities. The most common symptoms at diagnosis were mild ( n = 131, 63.9%). A total of 187 patients (91.2%) received mechanical ventilation, and 32 patients (15.6%) required extracorporeal membrane oxygenation. Patients were followed up for a median of 25 days after ICU admission. A total of 147 patients (71.7%) were alive at discharge, and 58 patients (28.3%) died. The hazard ratio for mortality among patients aged >80 years was 6.02 (95% confidence interval: 2.10−17.25) in the multivariable model, which was higher than that among those aged ≤59 years. These results are useful for recognizing the clinical course of this infection in ICU patients.
    Keywords intensive care unit (ICU) ; age ; mortality ; COVID-19 ; survival analysis ; Japan ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The clinical characteristics of COVID-19: a retrospective analysis of 104 patients from the outbreak on board the Diamond Princess cruise ship in Japan

    Tabata, Sakiko / Imai, Kazuo / Kawano, Shuichi / Ikeda, Mayu / Kodama, Tatsuya / Miyoshi, Kazuyasu / Obinata, Hirofumi / Mimura, Satoshi / Kodera, Tsutomu / Kitagaki, Manabu / Sato, Michiya / Suzuki, Satoshi / Ito, Toshimitsu / Uwabe, Yasuhide / Tamura, Kaku

    Abstract: ... with symptom onset and disease progression. Findings: The median age was 68 years, and 54 patients were male ... Background: The ongoing outbreak of the coronavirus disease 2019 (COVID-19) is a global threat ... features on admission among patients who were diagnosed with asymptomatic, mild, and severe COVID-19 ...

    Abstract Background: The ongoing outbreak of the coronavirus disease 2019 (COVID-19) is a global threat. Identification of markers for symptom onset and disease progression is a pressing issue. We compared the clinical features on admission among patients who were diagnosed with asymptomatic, mild, and severe COVID-19 at the end of observation. Methods: This retrospective, single-center study included 104 patients with laboratory-confirmed COVID-19 from the mass infection on the Diamond Princess cruise ship from February 11 to February 25, 2020. Clinical records, laboratory data, and radiological findings were analyzed. Clinical outcomes were followed up until February 26, 2020. Clinical features on admission were compared among those with different disease severity at the end of observation. Univariate analysis identified factors associated with symptom onset and disease progression. Findings: The median age was 68 years, and 54 patients were male. Briefly, 43, 41, and 20 patients on admission and 33, 43, and 28 patients at the end of observation had asymptomatic, mild, and severe COVID-19, respectively. Serum lactate hydrogenase levels were significantly higher in 10 patients who were asymptomatic on admission but developed symptomatic COVID-19 compared with 33 patients who remained asymptomatic throughout the observation period. Older age, consolidation on chest computed tomography, and lymphopenia on admission were more frequent in patients with severe COVID-19 than those with mild COVID-19 at the end of observation. Interpretation: Lactate dehydrogenase level is a potential predictor of symptom onset in COVID-19. Older age, consolidation on chest CT images, and lymphopenia might be risk factors for disease progression of COVID-19 and contribute to the clinical management. Funding: Not applicable.
    Keywords covid19
    Publisher MedRxiv
    Document type Article ; Online
    DOI 10.1101/2020.03.18.20038125
    Database COVID19

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