Article ; Online: Long-Term Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infectiousness Among Three Immunocompromised Patients: From Prolonged Viral Shedding to SARS-CoV-2 Superinfection.
The Journal of infectious diseases
2021 Volume 223, Issue 9, Page(s) 1522–1527
Abstract: ... superinfection with a second severe acute respiratory syndrome coronavirus 2 strain were observed, all leading ... the patients' epidemiological, clinical, and serological data, (2) infectiousness using viral culture, and (3 ... to prolonged infectious viral shedding for several months.: Conclusions: Understanding underlying mechanisms ...
| Abstract | Background: Guidelines for stopping coronavirus disease 2019 patient isolation are mainly symptom-based, with isolation for 10 to 20 days depending on their condition. Methods: In this study, we describe 3 deeply immunocompromised patients, each with different clinical evolutions. We observed (1) the patients' epidemiological, clinical, and serological data, (2) infectiousness using viral culture, and (3) viral mutations accumulated over time. Results: Asymptomatic carriage, symptom resolution, or superinfection with a second severe acute respiratory syndrome coronavirus 2 strain were observed, all leading to prolonged infectious viral shedding for several months. Conclusions: Understanding underlying mechanisms and frequency of prolonged infectiousness is crucial to adapt current guidelines and strengthen the use of systematic polymerase chain reaction testing before stopping isolation in immunocompromised populations. |
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| MeSH term(s) | Adult ; Aged ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19 Testing/methods ; Humans ; Immunocompromised Host ; Male ; Patient Isolation ; SARS-CoV-2 ; Superinfection/virology ; Virus Shedding | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2021-02-02 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 3019-3 | ||||||||||
| ISSN | 1537-6613 ; 0022-1899 | ||||||||||
| ISSN (online) | 1537-6613 | ||||||||||
| ISSN | 0022-1899 | ||||||||||
| DOI | 10.1093/infdis/jiab075 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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