Article ; Online: Clinical course and challenging management of early COVID-19 infection after heart transplantation: case report of two patients.
2021 Volume 21, Issue 1, Page(s) 89
Abstract: ... management of early COVID-19 infection in two heart transplant recipients who tested positive for the SARS ... immunosuppressed state.: Case presentation: This report describes the clinical course and the challenging ... organ transplant patients, especially in heart transplant recipients, with only a few case reports and case series ...
| Abstract | Background: There are limited data on Coronavirus disease 2019 (COVID-19) in solid organ transplant patients, especially in heart transplant recipients, with only a few case reports and case series described so far. Heart transplant recipients may be at particular high risk due to their comorbidities and immunosuppressed state. Case presentation: This report describes the clinical course and the challenging management of early COVID-19 infection in two heart transplant recipients who tested positive for the SARS-CoV-2 virus in the perioperative period of the transplant procedure. The two patients developed a severe form of the disease and ultimately died despite the initiation of an antiviral monotherapy with hydroxychloroquine coupled with the interruption of mycophenolate mofetil. Conclusions: These two cases illustrate the severity and poor prognosis of COVID-19 in the perioperative period of a heart transplant. Thorough screening of donors and recipients is mandatory, and the issue of asymptomatic carriers needs to be addressed. |
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| MeSH term(s) | Antimalarials/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19/complications ; COVID-19/therapy ; Comorbidity ; Female ; Heart Transplantation/adverse effects ; Humans ; Hydroxychloroquine/therapeutic use ; Immunocompromised Host ; Male ; Middle Aged ; Mycophenolic Acid/administration & dosage ; SARS-CoV-2 ; Transplant Recipients |
| Chemical Substances | Antimalarials ; Antiviral Agents ; Hydroxychloroquine (4QWG6N8QKH) ; Mycophenolic Acid (HU9DX48N0T) |
| Language | English |
| Publishing date | 2021-01-20 |
| Publishing country | England |
| Document type | Case Reports ; Journal Article |
| ZDB-ID | 2041550-3 |
| ISSN | 1471-2334 ; 1471-2334 |
| ISSN (online) | 1471-2334 |
| ISSN | 1471-2334 |
| DOI | 10.1186/s12879-021-05793-6 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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