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  1. Article ; Online: Effects of COVID-19 Lockdown on Tumour Burden of Melanoma and Cutaneous Squamous Cell Carcinoma.

    Tejera-Vaquerizo, Antonio / Paradela, Sabela / Toll, Agusti / Santos-Juanes, Jorge / Jaka, Ane / López, Alba / Cañueto, Javier / Bernal, Àlvaro / Villegas-Romero, Isabel / Ferrándiz-Pulido, Carla / Perandones, Héctor / Moreno-Ramírez, David / Domínguez-Mahamud, Carolina / Salido-Vallejo, Rafael / Sanmartin, Onofre / Almazán-Fernández, Francisco M / Rodríguez-Jiménez, Pedro / Bañuls, José / Podlipnik, Sebastian /
    Sandoval-Clavijo, Alejandra / Boada, Aram / García-Bracamonte, Beatriz / Palencia, Sara / Revilla-Nevreda, David / Reola-Ramírez, Enara / Del Carmen Gómez-Mateo, María / Linares-Barrios, Mario / Jiménez-Gallo, David / González-Cruz, Carlos / Samaniego, Elia / Navedo-de Las Heras, María / Taberner, Rosa / Ródenas-Herranz, Teresa / García-Donoso, Carmen / Puig, Susana / Nagore, Eduardo

    Acta dermato-venereologica

    2021  Volume 101, Issue 8, Page(s) adv00525

    Abstract: ... and cutaneous squamous cell carcinoma during nationwide lockdown in Spain due to COVID-19 ... were related to larger size cutaneous squamous cell carcinoma. In conclusion, lockdown due to COVID-19 ... diameter for cutaneous squamous cell carcinoma) and demographic, clinical, and medical factors were ...

    Abstract The aim of this study was to compare tumour burden in patients who underwent surgery for melanoma and cutaneous squamous cell carcinoma during nationwide lockdown in Spain due to COVID-19 (for the period 14 March to 13 June 2020) and during the same dates in 2019 before the COVID-19 pandemic. In addition, associations between median tumour burden (Breslow thickness for melanoma and maximum clinical diameter for cutaneous squamous cell carcinoma) and demographic, clinical, and medical factors were analysed, building a multivariate linear regression model. During the 3 months of lockdown, there was a significant decrease in skin tumours operated on (41% decrease for melanoma (n = 352 vs n = 207) and 44% decrease for cutaneous squamous cell carcinoma (n = 770 vs n = 429)) compared with the previous year. The proportion of large skin tumours operated on increased. Fear of SARS-CoV-2 infection, with respect to family member/close contact, and detection of the lesion by the patient or doctor, were related to thicker melanomas; and fear of being diagnosed with cancer, and detection of the lesion by the patient or relatives, were related to larger size cutaneous squamous cell carcinoma. In conclusion, lockdown due to COVID-19 has resulted in a reduction in treatment of skin cancer.
    MeSH term(s) COVID-19 ; Carcinoma, Squamous Cell/epidemiology ; Carcinoma, Squamous Cell/surgery ; Communicable Disease Control ; Humans ; Melanoma/epidemiology ; Melanoma/surgery ; Pandemics ; SARS-CoV-2 ; Skin Neoplasms/epidemiology ; Skin Neoplasms/surgery ; Tumor Burden
    Language English
    Publishing date 2021-08-25
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-3890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Estimación del efecto en el tamaño y la supervivencia de los tumores cutáneos debido al confinamiento por COVID-19: modelo basado en un crecimiento exponencial.

    Tejera-Vaquerizo, A / Cañueto, J / Toll, A / Santos-Juanes, J / Jaka, A / Ferrandiz-Pulido, C / Sanmartín, O / Ribero, S / Moreno-Ramírez, D / Almazán, F / Fuente, M J / Podlipnik, S / Nagore, E

    Actas dermo-sifiliograficas

    2020  Volume 111, Issue 8, Page(s) 629–638

    Abstract: ... of tumor growth caused by such delays in patients with squamous cell carcinoma (SCC) and melanoma ... neck and 1000 patients with cutaneous melanoma were included. An exponential growth curve was ... coronavirus disease 2019 (COVID-19) pandemic. One of the consequences of this lockdown is delays in medical ...

    Title translation Estimated Effect of COVID-19 Lockdown on Skin Tumor Size and Survival: An Exponential Growth Model.
    Abstract Background and objectives: Spain is in a situation of indefinite lockdown due to the ongoing coronavirus disease 2019 (COVID-19) pandemic. One of the consequences of this lockdown is delays in medical and surgical procedures for common diseases. The aim of this study was to model the impact on survival of tumor growth caused by such delays in patients with squamous cell carcinoma (SCC) and melanoma.
    Material and methods: Multicenter, retrospective, observational cohort study. We constructed an exponential growth model for both SCC and melanoma to estimate tumor growth between patient-reported onset and surgical excision at different time points.
    Results: Data from 200 patients with SCC of the head and neck and 1000 patients with cutaneous melanoma were included. An exponential growth curve was calculated for each tumor type and we estimated tumor size after 1, 2, and 3 months of potential surgical delay. The proportion of patients with T3 SCC (diameter >4cm or thickness >6 mm) increased from 41.5% (83 patients) in the initial study group to an estimated 58.5%, 70.5%, and 72% after 1, 2, and 3 months of delay. Disease-specific survival at 2, 5, and 10 years in patients whose surgery was delayed by 3 months decreased by 6.2%, 8.2%, and 5.2%, respectively. The proportion of patients with ultrathick melanoma (>6 mm) increased from 6.9% in the initial study group to 21.9%, 30.2%, and 30.2% at 1, 2, and 3 months. Five- and 10-year disease-specific survival both decreased by 14.4% in patients treated after a potential delay of 3 months.
    Conclusions: In the absence of adequate diagnosis and treatment of SCC and melanoma in the current lockdown situation in Spain, we can expect to see to a considerable increase in large and thick SCCs and melanomas. Efforts must be taken to encourage self-examination and facilitate access to dermatologists in order to prevent further delays.
    MeSH term(s) Age Factors ; Algorithms ; Betacoronavirus ; COVID-19 ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/pathology ; Coronavirus Infections/epidemiology ; Delayed Diagnosis/adverse effects ; Delayed Diagnosis/statistics & numerical data ; Female ; Head and Neck Neoplasms/mortality ; Head and Neck Neoplasms/pathology ; Health Services Accessibility ; Humans ; Male ; Melanoma/mortality ; Melanoma/pathology ; Pandemics ; Pneumonia, Viral/epidemiology ; Public Health Surveillance/methods ; Quarantine ; Retrospective Studies ; SARS-CoV-2 ; Sex Factors ; Skin Neoplasms/mortality ; Skin Neoplasms/pathology ; Spain/epidemiology ; Time Factors ; Time-to-Treatment ; Tumor Burden
    Keywords covid19
    Language Spanish
    Publishing date 2020-05-11
    Publishing country Spain
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 2541876-2
    ISSN 2173-5778 ; 2173-5778
    ISSN (online) 2173-5778
    ISSN 2173-5778
    DOI 10.1016/j.ad.2020.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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