LIVIVO - Search results -

Search results

Result 1 - 10 of total 1227

Search options

Article ; Online: Tissue-derived stem and progenitor cells.

Tesche, Leora J / Gerber, David A

2009 Volume 2010, Page(s) 824876

Abstract: The characterization and isolation of various stem cell populations, from embryonic through tissue ... the current state of research involving select tissue-derived stem cell populations including the liver ... derived stem cells, have led a rapid growth in the field of stem cell research. These research efforts ...

Abstract	The characterization and isolation of various stem cell populations, from embryonic through tissue-derived stem cells, have led a rapid growth in the field of stem cell research. These research efforts have often been interrelated as to the markers that identify a select cell population are frequently analyzed to determine their expression in cells of distinct organs/tissues. In this review, we will expand the current state of research involving select tissue-derived stem cell populations including the liver, central nervous system, and cardiac tissues as examples of the success and challenges in this field of research. Lastly, the challenges of clinical therapies will be discussed as it applies to these unique cell populations.
Language	English
Publishing date	2009-10-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573856-2
ISSN	1687-9678 ; 1687-966X
ISSN (online)	1687-9678
ISSN	1687-966X
DOI	10.4061/2010/824876
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Tissue-Derived Stem and Progenitor Cells

Leora J. Tesche / David A. Gerber

Stem Cells International, Vol

2010 Volume 2010

Abstract	The characterization and isolation of various stem cell populations, from embryonic through tissue-derived stem cells, have led a rapid growth in the field of stem cell research. These research efforts have often been interrelated as to the markers that identify a select cell population are frequently analyzed to determine their expression in cells of distinct organs/tissues. In this review, we will expand the current state of research involving select tissue-derived stem cell populations including the liver, central nervous system, and cardiac tissues as examples of the success and challenges in this field of research. Lastly, the challenges of clinical therapies will be discussed as it applies to these unique cell populations.
Keywords	Internal medicine ; RC31-1245
Language	English
Publishing date	2010-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Mesenchymal Stem/Progenitor Cells and Their Derivates in Tissue Regeneration-Part II.

Klimczak, Aleksandra

International journal of molecular sciences

2024 Volume 25, Issue 9

Abstract: During the last three decades, mesenchymal stem/stromal cells (MSCs) were extensively studied, and ... are mainly considered within the setting of their regenerative and immunomodulatory properties ... in tissue regeneration [...]. ...

Abstract	During the last three decades, mesenchymal stem/stromal cells (MSCs) were extensively studied, and are mainly considered within the setting of their regenerative and immunomodulatory properties in tissue regeneration [...].
MeSH term(s)	Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cells/cytology ; Humans ; Regeneration ; Animals ; Mesenchymal Stem Cell Transplantation/methods ; Tissue Engineering/methods ; Regenerative Medicine/methods ; Cell Differentiation
Language	English
Publishing date	2024-04-30
Publishing country	Switzerland
Document type	Editorial ; Introductory Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25094937
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Mesenchymal Stem/Progenitor Cells and Their Derivates in Tissue Regeneration.

Klimczak, Aleksandra

International journal of molecular sciences

2022 Volume 23, Issue 12

Abstract: Mesenchymal stem/stromal cells (MSC) have been extensively studied over the last 30 years ... in the context of their regenerative and immunomodulatory activities for potential application ...

Abstract	Mesenchymal stem/stromal cells (MSC) have been extensively studied over the last 30 years in the context of their regenerative and immunomodulatory activities for potential application in regenerative medicine [...].
MeSH term(s)	Immunomodulation ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells ; Regenerative Medicine ; Wound Healing
Language	English
Publishing date	2022-06-15
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23126652
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Clinical-scale expansion of a mixed population of bone-marrow-derived stem and progenitor cells for potential use in bone-tissue regeneration.

Dennis, James E / Esterly, Kelly / Awadallah, Amad / Parrish, Christopher R / Poynter, Gregory M / Goltry, Kristin L

Stem cells (Dayton, Ohio)

2007 Volume 25, Issue 10, Page(s) 2575–2582

Abstract: ... derived stem and progenitor cells for hematopoietic reconstitution. The current study tested the ability ... Preclinical and clinical studies have demonstrated the ability of bone marrow derived stem and ... of this bioreactor system to produce progenitor cells, termed tissue repair cells (TRC), possessing osteogenic ...

Abstract	Preclinical and clinical studies have demonstrated the ability of bone marrow derived stem and progenitor cells to regenerate many tissues, including bone. Methods to expand or enrich progenitors from bone marrow are common; however, these methods include many steps not amenable to clinical use. A closed automated cell production culture system was developed for clinical-scale ex vivo production of bone marrow-derived stem and progenitor cells for hematopoietic reconstitution. The current study tested the ability of this bioreactor system to produce progenitor cells, termed tissue repair cells (TRC), possessing osteogenic potential. Three TRC formulations were evaluated: (a) cells cultured without exogenous cytokines (TRC); (b) cells cultured with exogenous cytokines (TRC-C); and (c) an adherent subset of TRC-C (TRC-C(Ad)). Starting human bone marrow mononuclear cells (BM MNC) and TRC products were characterized for the expression of cell surface markers, in vitro colony forming ability, and in vivo osteogenic potential. Results showed significant expansion of mesenchymal progenitors (CD90+, CD105+, and CD166+) in each TRC formulation. In vivo bone formation, measured by histology, was highest in the TRC group, followed by TRC-C(Ad) and TRC-C. The TRC product outperformed starting BM MNC and had equivalent bone forming potential to purified MSCs at the same cell dose. Post hoc analysis revealed that the presence of CD90+, CD105+, and CD166+ correlated strongly with in vivo bone formation scores (r(2) > .95). These results demonstrate that this bioreactor system can be used to generate, in a single step, a population of progenitor cells with potent osteogenic potential. Disclosure of potential conflicts of interest is found at the end of this article.
MeSH term(s)	Adolescent ; Adult ; Animals ; Bioreactors ; Bone Marrow Cells/cytology ; Bone Marrow Cells/drug effects ; Bone and Bones/physiology ; Cell Culture Techniques/instrumentation ; Cell Culture Techniques/methods ; Erythropoietin/pharmacology ; Female ; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology ; Humans ; Interleukin-3/pharmacology ; Male ; Membrane Proteins/pharmacology ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stromal Cells/cytology ; Mesenchymal Stromal Cells/drug effects ; Mice ; Mice, SCID ; Middle Aged ; Osteoblasts/cytology ; Osteogenesis/physiology ; Prostheses and Implants ; Recombinant Fusion Proteins/pharmacology ; Tissue Engineering/methods
Chemical Substances	Interleukin-3 ; Membrane Proteins ; PIXY321 fusion protein, recombinant ; Recombinant Fusion Proteins ; flt3 ligand protein ; Erythropoietin (11096-26-7) ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1)
Language	English
Publishing date	2007-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1143556-2
ISSN	1549-4918 ; 1066-5099
ISSN (online)	1549-4918
ISSN	1066-5099
DOI	10.1634/stemcells.2007-0204
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1894: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Use of Brain-Derived Stem/Progenitor Cells and Derived Extracellular Vesicles to Repair Damaged Neural Tissues: Lessons Learned from Connective Tissue Repair Regarding Variables Limiting Progress and Approaches to Overcome Limitations.

Hart, David A

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: ... of extracellular vesicles from stem/progenitor cells that could be used to stimulate endogenous cells to repair ... Pluripotent neural stem or progenitor cells (NSC/NPC) have been reported in the brains of adult ... preclinical models for decades, as have mesenchymal stem/stromal cells (MSC) been reported in a variety ...

Abstract	Pluripotent neural stem or progenitor cells (NSC/NPC) have been reported in the brains of adult preclinical models for decades, as have mesenchymal stem/stromal cells (MSC) been reported in a variety of tissues from adults. Based on their in vitro capabilities, these cell types have been used extensively in attempts to repair/regenerate brain and connective tissues, respectively. In addition, MSC have also been used in attempts to repair compromised brain centres. However, success in treating chronic neural degenerative conditions such as Alzheimer's disease, Parkinson's disease, and others with NSC/NPC has been limited, as have the use of MSC in the treatment of chronic osteoarthritis, a condition affecting millions of individuals. However, connective tissues are likely less complex than neural tissues regarding cell organization and regulatory integration, but some insights have been gleaned from the studies regarding connective tissue healing with MSC that may inform studies attempting to initiate repair and regeneration of neural tissues compromised acutely or chronically by trauma or disease. This review will discuss the similarities and differences in the applications of NSC/NPC and MSC, where some lessons have been learned, and potential approaches that could be used going forward to enhance progress in the application of cellular therapy to facilitate repair and regeneration of complex structures in the brain. In particular, variables that may need to be controlled to enhance success are discussed, as are different approaches such as the use of extracellular vesicles from stem/progenitor cells that could be used to stimulate endogenous cells to repair the tissues rather than consider cell replacement as the primary option. Caveats to all these efforts relate to whether cellular repair initiatives will have long-term success if the initiators for neural diseases are not controlled, and whether such cellular initiatives will have long-term success in a subset of patients if the neural diseases are heterogeneous and have multiple etiologies.
MeSH term(s)	Humans ; Stem Cells ; Mesenchymal Stem Cells ; Brain ; Connective Tissue ; Extracellular Vesicles
Language	English
Publishing date	2023-02-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043370
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Mesenchymal Stem/Progenitor Cells and Their Derivates in Tissue Regeneration

Aleksandra Klimczak

International Journal of Molecular Sciences, Vol 23, Iss 6652, p

2022 Volume 6652

Abstract	Mesenchymal stem/stromal cells (MSC) have been extensively studied over the last 30 years in the context of their regenerative and immunomodulatory activities for potential application in regenerative medicine [.]
Keywords	n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Application of External Force Regulates the Migration and Differentiation of Adipose-Derived Stem/Progenitor Cells by Altering Tissue Stiffness.

Li, Ye / Wu, Mengfan / Zhang, Ziang / Xia, Jing / Wang, Zijue / Chen, Xinyao / Xiao, Xiuyun / Lu, Feng / Dong, Ziqing

Tissue engineering. Part A

2019 Volume 25, Issue 23-24, Page(s) 1614–1622

Abstract: ... expansion regulates adipose-derived stem/progenitor cells (ASCs) migration and differentiation ... of adipose-derived stem/progenitor cells (ASCs). In addition, we performed finite element analysis to explore ... engineering applications and improvements in stem cell therapy. ...

Abstract	Large soft-tissue defects are challenging to reconstruct surgically. Expansion of soft tissue using an external volume expansion (EVE) device is a noninvasive method to improve such reconstruction; however, the underlying mechanism is unclear. In this study, we created fat flaps in Sprague-Dawley rats, applied an external force of 3 or 6 kPa using an EVE device, and investigated the migration and differentiation of adipose-derived stem/progenitor cells (ASCs). In addition, we performed finite element analysis to explore the stiffness of adipose tissue. An external force of 3 kPa promoted the migration and adipogenic differentiation of ASCs. By comparison, an external force of 6 kPa had a larger effect on migration of ASCs, but a smaller effect on adipogenic differentiation of ASCs. External force affected adipose tissue stiffness. In conclusion, external force generated by an EVE device increases the stiffness of adipose tissue, which influences the migration and differentiation of ASCs. The size of the external force can be altered according to the tissue stiffness required at particular time points to promote long-term adipose tissue regeneration. Impact Statement Stem cell therapy in clinic mostly requires the addition of exogenous stem cells, therefore the safety and controllability is always defective. In this study, the external force of external volume expansion regulates adipose-derived stem/progenitor cells (ASCs) migration and differentiation through tissue stiffness. Using tissue engineering without exogenous ASCs can promote long-term adipose tissue regeneration. The findings of this study provide theoretical support for clinical tissue engineering applications and improvements in stem cell therapy.
MeSH term(s)	Adipogenesis ; Adipose Tissue/cytology ; Animals ; Antigens, CD34/metabolism ; Biomechanical Phenomena ; Cell Movement ; Cell Proliferation ; Computer Simulation ; Finite Element Analysis ; Male ; Proliferating Cell Nuclear Antigen/metabolism ; Rats, Sprague-Dawley ; Stem Cells/cytology ; Stress, Mechanical ; Surgical Flaps
Chemical Substances	Antigens, CD34 ; Proliferating Cell Nuclear Antigen
Language	English
Publishing date	2019-11-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2420582-5
ISSN	1937-335X ; 1937-3341
ISSN (online)	1937-335X
ISSN	1937-3341
DOI	10.1089/ten.TEA.2019.0046
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5500/A: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Combined Transplantation of Adipose Tissue-Derived Stem Cells and Endothelial Progenitor Cells Improve Diabetic Erectile Dysfunction in a Rat Model.

Yang, Qiyun / Chen, Wanmei / Zhang, Chi / Xie, Yun / Gao, Yong / Deng, Cuncan / Sun, Xiangzhou / Liu, Guihua / Deng, Chunhua

Stem cells international

2020 Volume 2020, Page(s) 2154053

Abstract: ... whether combined transplantation of adipose tissue-derived stem cells (ADSCs) and endothelial progenitor cells ... Stem cell transplantation is a promising strategy for the treatment of diabetic ED (DED). In this study, we evaluated ... intraperitoneal injection of streptozotocin (50 mg/kg), and ED was screened by apomorphine (100 mg/kg). DED rats were ...

Abstract	Erectile dysfunction (ED) is a common complication in men suffered with diabetic mellitus. Stem cell transplantation is a promising strategy for the treatment of diabetic ED (DED). In this study, we evaluated whether combined transplantation of adipose tissue-derived stem cells (ADSCs) and endothelial progenitor cells (EPCs) could improve the erectile function of the DED rat model. DED rats were induced via intraperitoneal injection of streptozotocin (50 mg/kg), and ED was screened by apomorphine (100 mg/kg). DED rats were divided into 4 groups (
Language	English
Publishing date	2020-07-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573856-2
ISSN	1687-9678 ; 1687-966X
ISSN (online)	1687-9678
ISSN	1687-966X
DOI	10.1155/2020/2154053
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Repair of Bone Defects With Endothelial Progenitor Cells and Bone Marrow-Derived Mesenchymal Stem Cells With Tissue-Engineered Bone in Rabbits.

Zhao, Xian / Han, Xue-Song / Zhou, Qing-Zhu / Liu, Bo-Yan / Yang, Bin / Gong, Zhuo / Wang, Song-Mei / Wang, Fu-Ke

Annals of plastic surgery

2020 Volume 85, Issue 4, Page(s) 430–436

Abstract: ... with tissue-engineered bones using cocultured endothelial progenitor cells (EPCs) and bone marrow mesenchymal stem cells ... BMSCs) as seeding cells.: Methods: Endothelial progenitor cells and BMSCs were isolated and purified ... cultured alone or with EPCs. Cells were characterized using specific markers and then seeded on partially ...

Abstract	Purpose: This study aimed to investigate the repair of bone defects in rabbits with tissue-engineered bones using cocultured endothelial progenitor cells (EPCs) and bone marrow mesenchymal stem cells (BMSCs) as seeding cells. Methods: Endothelial progenitor cells and BMSCs were isolated and purified from the peripheral blood and bone marrow, respectively, of New Zealand rabbits. The third passage of BMSCs was cultured alone or with EPCs. Cells were characterized using specific markers and then seeded on partially deproteinized biologic bones from pigs as a scaffold. The engineered bones were used to repair bone defects in rabbits. Hematoxylin and eosin and Masson staining were performed to examine vascularization and osteogenesis in the engineered bone. Results: The cocultured EPCs and BMSCs grew well on the surface of the scaffold. Compared with monocultured BMSCs, cocultured EPCs and BMSCs promoted the formation of blood vessels and bone on the scaffold, in addition to accelerating the repair of bone defects. The collagen content was significantly increased in the scaffold with cocultured EPCs and BMSCs, compared with the scaffold seeded with mono-cultured BMSCs. Conclusions: Tissue-engineered bones seeded with cocultured EPCs and BMSCs may be used effectively for the repair of bone defects.
MeSH term(s)	Animals ; Bone Marrow ; Bone Marrow Cells ; Cells, Cultured ; Endothelial Progenitor Cells ; Mesenchymal Stem Cells ; Osteogenesis ; Rabbits ; Swine ; Tissue Engineering ; Tissue Scaffolds
Language	English
Publishing date	2020-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	423835-7
ISSN	1536-3708 ; 0148-7043
ISSN (online)	1536-3708
ISSN	0148-7043
DOI	10.1097/SAP.0000000000002454
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1419: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito