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Article ; Online: Start as we mean to go on.

The Lancet Microbe

The Lancet. Microbe

2020 Volume 1, Issue 1, Page(s) e1

MeSH term(s)	COVID-19 ; Humans ; Kinetics ; SARS-CoV-2 ; Tropism
Keywords	covid19
Language	English
Publishing date	2020-05-11
Publishing country	England
Document type	Editorial ; Comment
ISSN	2666-5247
ISSN (online)	2666-5247
DOI	10.1016/S2666-5247(20)30016-1
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Article ; Online: Start as we mean to go on

The Lancet Microbe

Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1016/s2666-5247(20)30016-1
Database	COVID19

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Article ; Online: Start as we mean to go on

The Lancet Microbe

The Lancet Microbe, Vol 1, Iss 1, Pp e1- (2020)

2020

Keywords	Medicine (General) ; R5-920 ; Microbiology ; QR1-502
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Newborn and early years. Start as you mean to go on.

The Health service journal

2010 Volume Suppl, Page(s) 1–3

MeSH term(s)	Child Welfare ; Child, Preschool ; Humans ; Infant Care ; Infant Welfare ; Infant, Newborn ; Parenting ; Program Development ; United Kingdom
Language	English
Publishing date	2010-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	632799-0
ISSN	0952-2271 ; 0300-8347
ISSN	0952-2271 ; 0300-8347
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Article: Start as you mean to go on.

Caulfield, H

Nursing standard (Royal College of Nursing (Great Britain) : 1987)

2000 Volume 15, Issue 1, Page(s) 21

MeSH term(s)	Accreditation/organization & administration ; Education, Nursing/standards ; Facility Regulation and Control/organization & administration ; Health Planning ; Humans ; Licensure, Nursing ; Organizational Objectives ; Registries ; Schools, Nursing/standards ; State Medicine ; United Kingdom
Language	English
Publishing date	2000-09
Publishing country	England
Document type	Journal Article
ZDB-ID	645016-7
ISSN	2047-9018 ; 0029-6570
ISSN (online)	2047-9018
ISSN	0029-6570
DOI	10.7748/ns.15.1.21.s39
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Zs.A 2410: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Is colchicine prophylaxis required with start-low go-slow allopurinol dose escalation in gout? A non-inferiority randomised double-blind placebo-controlled trial.

Stamp, Lisa / Horne, Anne / Mihov, Borislav / Drake, Jill / Haslett, Janine / Chapman, Peter T / Frampton, Christopher / Dalbeth, Nicola

Annals of the rheumatic diseases

2023 Volume 82, Issue 12, Page(s) 1626–1634

Abstract: ... flares during the first 6 months of allopurinol using the 'start-low go-slow' dose approach.: Methods ... of starting allopurinol using the 'start-low go-slow' strategy. After stopping colchicine, gout flares rise ... the mean number of gout flares/month between 0 and 6 months, with a prespecified non-inferiority margin ...

Abstract	Objectives: To determine whether placebo is non-inferior to low-dose colchicine for reducing gout flares during the first 6 months of allopurinol using the 'start-low go-slow' dose approach. Methods: A 12-month double-blind, placebo-controlled non-inferiority trial was undertaken. Adults with at least one gout flare in the preceding 6 months, fulfilling the American College of Rheumatology (ACR) recommendations for starting urate-lowering therapy and serum urate ≥0.36 mmol/L were recruited. Participants were randomised 1:1 to colchicine 0.5 mg daily or placebo for the first 6 months. All participants commenced allopurinol, increasing monthly to achieve target urate <0.36 mmol/L. The primary efficacy outcome was the mean number of gout flares/month between 0 and 6 months, with a prespecified non-inferiority margin of 0.12 gout flares/month. The primary safety outcome was adverse events over the first 6 months. Results: Two hundred participants were randomised. The mean (95% CI) number of gout flares/month between baseline and month 6 was 0.61 (0.47 to 0.74) in the placebo group compared with 0.35 (0.22 to 0.49) in the colchicine group, mean difference 0.25 (0.07 to 0.44), non-inferiority p=0.92. There was no difference in the mean number of gout flares/month between randomised groups over the 12-month period (p=0.68). There were 11 serious adverse events in 7 participants receiving colchicine and 3 in 2 receiving placebo. Conclusions: Placebo is not non-inferior to colchicine in prevention of gout flares in the first 6 months of starting allopurinol using the 'start-low go-slow' strategy. After stopping colchicine, gout flares rise with no difference in the mean number of gout flares/month between groups over a 12-month period. Trial registration number: ACTRN 12618001179224.
MeSH term(s)	Adult ; Humans ; Gout/drug therapy ; Allopurinol/therapeutic use ; Colchicine/therapeutic use ; Gout Suppressants/therapeutic use ; Uric Acid ; Symptom Flare Up ; Treatment Outcome
Chemical Substances	Allopurinol (63CZ7GJN5I) ; Colchicine (SML2Y3J35T) ; Gout Suppressants ; Uric Acid (268B43MJ25)
Language	English
Publishing date	2023-08-31
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/ard-2023-224731
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Article ; Online: Prescripción potencialmente inadecuada: utilidad de los criterios STOPP/START versión 2 a nivel poblacional en Cataluña.

Fuertes Abardía, C / Ballesta Juan, P / Cruz Esteve, I / Galindo Ortego, G / Marsal Mora, J R / Gómez-Arbonés, X

Semergen

2022 Volume 48, Issue 3, Page(s) 163–173

Abstract: ... are adjusted to determine PIP association with several factors.: Results: The mean age is 79. 2±6.5 ... 58.5% being female. 38.7% of patients have 7 or more prescribed drugs, whereas 50% go to a primary ... Tool to Alert doctors to Right Treatment (STOPP/START) version 2. In addition, to evaluate ...

Title translation	Potentially inappropriate prescribing: Usefulness of STOPP/START criteria version 2 in Catalonian elderly population.
Abstract	Objective: To measure the prevalence of potentially inappropriate prescribing (PIP) among the elderly population in Catalonia using criteria Screening Tool of Older Person's Prescriptions/Screening Tool to Alert doctors to Right Treatment (STOPP/START) version 2. In addition, to evaluate the association between PIP and several factors (polypharmacy, gender, age and sociodemographic conditions). Materials and methods: Design: Retrospective cross sectional population study. Settings: Primary Health Care, Catalonia, Spain. Participants: The study population comprised of participants 70 years old and over, who attended primary health care centres in Catalonia in 2014 (700.058 patients). Main analysis: 55 STOPP and 19 START criteria are applied to analyse PIP prevalence. Logistic regression models are adjusted to determine PIP association with several factors. Results: The mean age is 79. 2±6.5. 58.5% being female. 38.7% of patients have 7 or more prescribed drugs, whereas 50% go to a primary care centre 10 or more times during one year. The most frequent PIP among STOPP criteria are related to nonsteroidal anti-inflammatory drug intake, antiplatelet and anticoagulants use, and benzodiazepines. According to START, the most frequent omissions are vitamin D and calcium supplements, antidepressants, and cardiovascular medications. Factors that increase PIP are: female gender, living in a nursing home, receiving home health care, polypharmacy and frequent visits to primary care centres. Conclusions: The overall prevalence of PIP is 89.6%. PPI is significantly related to certain drugs and patient's conditions. The knowledge of this association is important for the implementation of security measures for medical prescription.
MeSH term(s)	Aged ; Cross-Sectional Studies ; Female ; Humans ; Inappropriate Prescribing/prevention & control ; Male ; Potentially Inappropriate Medication List ; Retrospective Studies ; Spain
Language	Spanish
Publishing date	2022-02-09
Publishing country	Spain
Document type	Journal Article
ISSN	1578-8865
ISSN (online)	1578-8865
DOI	10.1016/j.semerg.2021.09.005
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Article ; Online: People with intellectual and sensory disabilities can independently start and perform functional daily activities with the support of simple technology.

Lancioni, Giulio E / Singh, Nirbhay N / O'Reilly, Mark F / Sigafoos, Jeff / Alberti, Gloria / Del Gaudio, Valentina / Abbatantuono, Chiara / Taurisano, Paolo / Desideri, Lorenzo

PloS one

2022 Volume 17, Issue 6, Page(s) e0269793

Abstract: ... the participants started independently was below 7; the mean frequency of correct responses per activity was below ... designs across participants.: Results: During baseline, the mean percentage of activities ... of the technology system), the mean percentage and mean frequency values increased to nearly 100 and 8, respectively ...

Abstract	Objectives: The study assessed a smartphone-based technology system, which was designed to enable six participants with intellectual disability and sensory impairment to start and carry out functional activities through the use of reminders and verbal or pictorial instructions. Methods: The technology system involved a Samsung Galaxy A22 with Android 11 operating system and four Philips Hue indoor motion sensors. Three to five activities were scheduled per day. At the time at which an activity was due, the system provided the participant with a reminder followed by the verbal or pictorial instruction for the initial part of the first response (e.g., "Go to the bathroom and take the dirty towels"). The instruction would be available (repeated) until the participant responded to it and, in so doing, activated a sensor. Sensor activation caused the presentation of the instruction for the second part of the same (first) response (e.g., "Put the towels in the laundry machine"). The same process occurred for each of the responses involved in the activity. The system was introduced according to nonconcurrent multiple baseline designs across participants. Results: During baseline, the mean percentage of activities the participants started independently was below 7; the mean frequency of correct responses per activity was below 0.5 (out of a maximum possible of 8). During the intervention (i.e., with the support of the technology system), the mean percentage and mean frequency values increased to nearly 100 and 8, respectively. Conclusions: The data suggest that the aforementioned technology system may enable people with intellectual disability and sensory impairment to start and carry out functional activities independent of staff.
MeSH term(s)	Deafness ; Disabled Persons ; Humans ; Intellectual Disability ; Smartphone ; Technology
Language	English
Publishing date	2022-06-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0269793
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Article ; Online: Getting going on time: reducing neurophysiology set-up times in order to contribute to improving surgery start and finish times.

Pridgeon, Michael / Proudlove, Nathan

BMJ open quality

2022 Volume 11, Issue 3

Abstract: ... from a mean of 70 min to around 50 min. We saw improvements in surgical start times and session finish times ... patient monitoring by neurophysiology clinical scientists. Before the surgeon can start the operation ... the anaesthetist was finished, therefore not introducing delays to the start of surgery. A final change was ...

Abstract	At the Walton Centre we conduct a relatively large number of complex and lengthy elective (booked) spinal operations. Recently, we have had a particular problem with half or more of these sessions finishing late, resulting in staff discontent and greater use of on-call staff.These operations require patient monitoring by neurophysiology clinical scientists. Before the surgeon can start the operation, in-theatre neurophysiological measurements are required to establish a baseline. We reasoned that reducing this set-up time would reduce the risk of surgery starting late, and so the whole session finishing later than expected.In this project we redesigned the neurophysiology parts of in-theatre patient preparation. We conducted five Plan-Do-Study-Act cycles over 3 months, reducing the duration of pre-surgery preparation from a mean of 70 min to around 50 min. We saw improvements in surgical start times and session finish times (both earlier by roughly comparable amounts). The ultimately impact is that we saw on-time session finishes improve from around 50% to 100%. Following this project, we have managed to sustain the changes and the improved performance.The most impactful change was to conduct in-theatre neurophysiology patient preparation simultaneously with anaesthesia, rather than waiting for this to finish; when we performed this with a pair of clinical scientists, we were able to complete neurophysiology patient preparation by the time the anaesthetist was finished, therefore not introducing delays to the start of surgery. A final change was to remove a superfluous preparatory patient-baseline measurement.This is a very challenging and complex environment, with powerful stakeholders and many factors and unpredictable events affecting sessions. Nevertheless, we have shown that we can make improvements within our span of influence that improve the wider process. While using pairs of staff requires greater resource, we found the benefit to be worthwhile.
MeSH term(s)	Elective Surgical Procedures ; Humans ; Neurophysiology ; Operating Rooms ; Operative Time ; Surgeons
Language	English
Publishing date	2022-07-19
Publishing country	England
Document type	Journal Article
ISSN	2399-6641
ISSN (online)	2399-6641
DOI	10.1136/bmjoq-2021-001808
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Article ; Online: High School Start Time and Migraine Frequency in High School Students.

Gelfand, Amy A / Pavitt, Sara / Greene, Kaitlin / Szperka, Christina L / Irwin, Samantha / Grimes, Barbara / Allen, Isabel E

Headache

2019 Volume 59, Issue 7, Page(s) 1024–1031

Abstract: ... set: 115 later group vs 141 earlier group. Age and sex did not differ. Mean (SD) self-reported ... headache days/month were 7 (5) vs 8 (7), respectively, (P = .985); mean difference (95% CI ... Objective: To investigate whether later high school start time is associated with lower migraine ...

Abstract	Objective: To investigate whether later high school start time is associated with lower migraine frequency in high school students with migraine. Background: Adequate sleep is thought to be important in managing adolescent migraine. The American Academy of Sleep Medicine recommends teenagers sleep ≥8 hours/night. Adolescents have a physiologically delayed sleep phase, going to bed, and waking later than children and adults. The American Academy of Pediatrics (AAP) accordingly recommends high schools start no earlier than 8:30 AM. Methods: Cross-sectional observational study of U.S. high schoolers with migraine. Participants were recruited nationally using social media. Respondents attending high schools starting at 8:30 AM or later were compared to those attending earlier start time schools. The primary outcome was headache days/month. Results: Two hundred and fifty-six subjects constituted the analysis set: 115 later group vs 141 earlier group. Age and sex did not differ. Mean (SD) self-reported headache days/month were 7 (5) vs 8 (7), respectively, (P = .985); mean difference (95% CI for the difference) was -0.8 (-2.3-0.7) days. Median (IQR) self-reported total hours of sleep/school night were: 5.6 (5.0-6.6) vs 5.6 (4.5-6.4), P = .058. Students attending later start time schools woke later (median [IQR] 6:38 AM [55 minutes] vs 6:09 AM [59 minutes], P < .0001) and left home later (median [IQR] 7:28 AM [28 minutes] vs 7:02 AM [60 minutes], P < .0001). Average commute time was also longer: 41 (21) minutes vs 28 (16), P < .0001. The vast majority in both groups reported missing breakfast at least once/week: 103/114 (90.4%) vs 128/141 (90.8%), P = .907. Hours of sleep did not correlate with headache days per month. Conclusion: High school start time does not have a large effect on headache frequency in high schoolers with migraine. Given the high variance in headache days/month observed in this study, a larger study would be needed to determine whether there might still be a small effect of starting high school at/after 8:30 AM. More research is needed to establish evidence-based recommendations about lifestyle factors in adolescent migraine management.
MeSH term(s)	Adolescent ; Cross-Sectional Studies ; Female ; Humans ; Male ; Migraine Disorders/epidemiology ; Migraine Disorders/physiopathology ; Schools/statistics & numerical data ; Sleep/physiology ; Students/statistics & numerical data ; Time Factors ; United States/epidemiology ; Wakefulness/physiology
Language	English
Publishing date	2019-04-24
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	410130-3
ISSN	1526-4610 ; 0017-8748
ISSN (online)	1526-4610
ISSN	0017-8748
DOI	10.1111/head.13535
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