Article ; Online: Cytokine storm induced by SARS-CoV-2 infection: The spectrum of its neurological manifestations.
2020 Volume 138, Page(s) 155404
Abstract: ... coronavirus 2 (SARS-CoV-2), can trigger a hyperinflammatory state characterized by elevated cytokine levels ... peripheral nervous systems have also been reported. This review discusses potential routes of SARS-CoV-2 neuroinvasion and ... may precipitate these complications. Clarification of the pathogenic mechanisms of SARS-CoV-2 is needed ...
| Abstract | The new coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can trigger a hyperinflammatory state characterized by elevated cytokine levels known as hypercytokinemia or cytokine storm, observed most often in severe patients. Though COVID-19 is known to be a primarily respiratory disease, neurological complications affecting both the central and peripheral nervous systems have also been reported. This review discusses potential routes of SARS-CoV-2 neuroinvasion and pathogenesis, summarizes reported neurological sequelae of COVID-19, and examines how aberrant cytokine levels may precipitate these complications. Clarification of the pathogenic mechanisms of SARS-CoV-2 is needed to encourage prompt diagnosis and optimized care. In particular, identifying the presence of cytokine storm in patients with neurological COVID-19 manifestations will facilitate avenues for treatment. Future investigations into aberrant cytokine levels in COVID-19 patients with neurological symptoms as well as the efficacy of cytokine storm-targeting treatments will be critical in elucidating the pathogenic mechanisms and effective treatments of COVID-19. |
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| MeSH term(s) | COVID-19/pathology ; COVID-19/therapy ; Central Nervous System/pathology ; Cerebrovascular Disorders/pathology ; Cerebrovascular Disorders/virology ; Cytokine Release Syndrome/pathology ; Cytokine Release Syndrome/therapy ; Cytokines/blood ; Humans ; Nervous System Diseases/pathology ; Nervous System Diseases/virology ; Peripheral Nervous System/pathology ; SARS-CoV-2 | |||||
| Chemical Substances | Cytokines | |||||
| Language | English | |||||
| Publishing date | 2020-12-11 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 1018055-2 | |||||
| ISSN | 1096-0023 ; 1043-4666 | |||||
| ISSN (online) | 1096-0023 | |||||
| ISSN | 1043-4666 | |||||
| DOI | 10.1016/j.cyto.2020.155404 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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