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  1. Article: Update on imaging-based diagnosis of acute renal allograft rejection.

    Köhnke, Richard / Kentrup, Dominik / Schütte-Nütgen, Katharina / Schäfers, Michael / Schnöckel, Uta / Hoerr, Verena / Reuter, Stefan

    American journal of nuclear medicine and molecular imaging

    2019  Volume 9, Issue 2, Page(s) 110–126

    Abstract: ... summarizing current imaging-based approaches for non-invasive diagnosis of acute renal allograft rejection. ... organ for specific and rapid detection of acute allograft rejection is desirable. We herein provide a review ... disease. Despite effective immunosuppressants, acute allograft rejections pose a major threat to graft survival ...

    Abstract Kidney transplantation is the preferred treatment for patients with end-stage renal disease. Despite effective immunosuppressants, acute allograft rejections pose a major threat to graft survival. In early stages, acute rejections are still potentially reversible, and early detection is crucial to initiate the necessary treatment options and to prevent further graft dysfunction or even loss of the complete graft. Currently, invasive core needle biopsy is the reference standard to diagnose acute rejection. However, biopsies carry the risk of graft injuries and cannot be immediately performed on patients receiving anticoagulation drugs. Therefore, non-invasive assessment of the whole organ for specific and rapid detection of acute allograft rejection is desirable. We herein provide a review summarizing current imaging-based approaches for non-invasive diagnosis of acute renal allograft rejection.
    Language English
    Publishing date 2019-04-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2623515-8
    ISSN 2160-8407
    ISSN 2160-8407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Imaging-based diagnosis of acute renal allograft rejection.

    Thölking, Gerold / Schuette-Nuetgen, Katharina / Kentrup, Dominik / Pawelski, Helga / Reuter, Stefan

    World journal of transplantation

    2016  Volume 6, Issue 1, Page(s) 174–182

    Abstract: ... based state of the art approaches for non-invasive diagnostics of acute renal transplant rejection ... organ for specific and fast detection of acute allograft rejection is desirable. We herein review current imaging ... disease. Despite the introduction of effective immunosuppressant drugs, episodes of acute allograft rejection still ...

    Abstract Kidney transplantation is the best available treatment for patients with end stage renal disease. Despite the introduction of effective immunosuppressant drugs, episodes of acute allograft rejection still endanger graft survival. Since efficient treatment of acute rejection is available, rapid diagnosis of this reversible graft injury is essential. For diagnosis of rejection, invasive core needle biopsy of the graft is the "gold-standard". However, biopsy carries the risk of significant graft injury and is not immediately feasible in patients taking anticoagulants. Therefore, a non-invasive tool assessing the whole organ for specific and fast detection of acute allograft rejection is desirable. We herein review current imaging-based state of the art approaches for non-invasive diagnostics of acute renal transplant rejection. We especially focus on new positron emission tomography-based as well as targeted ultrasound-based methods.
    Language English
    Publishing date 2016-03-08
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2220-3230
    ISSN 2220-3230
    DOI 10.5500/wjt.v6.i1.174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Imaging in Renal Transplants: An Update.

    Volkan-Salanci, Bilge / Erbas, Belkis

    Seminars in nuclear medicine

    2021  Volume 51, Issue 4, Page(s) 364–379

    Abstract: ... subacute and/or acute rejection, infections, toxicity due to immunosuppressive medications, complications ... relating the collecting system, chronic rejection are the main causes for renal function impairment ... on radionuclide imaging is focused on perfusion analysis for the early diagnosis of renal transplant dysfunction and ...

    Abstract Renal transplantation has become the best treatment for the patients with chronic renal insufficiency. The surgical procedures, immunosuppressive regiments and patient follow-up have evolved especially in the last 10 years. However, the diagnosis for renal transplantation dysfunction remained the same in these years. Serum creatinine levels and estimated glomerular filtration rate calculated by serum creatinine based equations are used in routine patient follow-up. Pelvic ultrasonography and color Doppler ultrasonography are used as a first-line imaging method. Assessment of allograft functions both qualitatively and quantitatively are possible using nuclear medicine procedures. Surgical complications, acute tubular necrosis, subacute and/or acute rejection, infections, toxicity due to immunosuppressive medications, complications relating the collecting system, chronic rejection are the main causes for renal function impairment. The imaging procedures can diagnose the worsening of renal transplant function; however, they still lack the ability to differentiate types of rejection as histopathology or differentiate rejection from other causes of allograft dysfunction. The transplant biopsy gives detailed diagnosis for allograft dysfunction, guide the treatment and therefore it is the preferred diagnostic choice in recent years. On recent years, literature on radionuclide imaging is focused on perfusion analysis for the early diagnosis of renal transplant dysfunction and prognostic use of perfusion parameters, and then this article will focus on these studies and their outcome.
    MeSH term(s) Graft Rejection ; Humans ; Kidney ; Kidney Transplantation/adverse effects ; Radionuclide Imaging
    Language English
    Publishing date 2021-01-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 120248-0
    ISSN 1558-4623 ; 0001-2998
    ISSN (online) 1558-4623
    ISSN 0001-2998
    DOI 10.1053/j.semnuclmed.2020.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 763: Show issues Location:
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  4. Article ; Online: Noninvasive Imaging of Acute Renal Allograft Rejection by Ultrasound Detection of Microbubbles Targeted to T-lymphocytes in Rats.

    Grabner, A / Kentrup, D / Mühlmeister, M / Pawelski, H / Biermann, C / Bettinger, T / Pavenstädt, H / Schlatter, E / Tiemann, K / Reuter, S

    Ultraschall in der Medizin (Stuttgart, Germany : 1980)

    2016  Volume 37, Issue 1, Page(s) 82–91

    Abstract: ... T-lymphocytes for image-based diagnosis of acute allograft rejection (AR) established in a rat renal ... rats subjected to acute cyclosporin A toxicity (CSA) (cyclosporine 50 mg/kg BW for 2 days i. p.) served ... and highly specific assessment of AR in a rat model of renal transplantation. ...

    Abstract Purpose: We propose CD3-antibody-mediated contrast-enhanced ultrasonography using human T-lymphocytes for image-based diagnosis of acute allograft rejection (AR) established in a rat renal transplantation model.
    Materials and methods: 15 minutes after tail vein injection of 30 × 10(6) human T-lymphocytes, contrast media/microbubbles conjugated with an anti-human CD3 antibody was applied to uni-nephrectomized 10-week-old allogeneically transplanted male rats (Lewis-Brown Norway (LBN) to Lewis, aTX) and ultrasound was performed to investigate the transplanted kidney as well as the native kidney. In vivo results were confirmed via immunohistochemical stainings of CD3 after post mortem dissection. Syngeneically transplanted rats (LBN to LBN, sTX), rats with ischemia/reperfusion injury (IRI, 45 min. warm ischemia), and rats subjected to acute cyclosporin A toxicity (CSA) (cyclosporine 50 mg/kg BW for 2 days i. p.) served as controls.
    Results: Accumulation of human T-lymphocytes was clearly detected by antibody-mediated sonography und was significantly increased in allografts undergoing AR (5.41 ± 1.32 A. U.) when compared to native control kidneys (0.70 ± 0.08 A. U.). CD3 signal intensity was low in native kidneys, sTX (0.99 ± 0.30 A. U.), CSA (0.10 ± 0.02 A. U.) and kidneys with IRI (0.46 ± 0.29 A. U.). Quantification of the ultrasound signal correlated significantly with the T-cell numbers obtained by immunohistochemical analysis (R2 = 0.57).
    Conclusion: Contrast-enhanced sonography using CD3-antibodies is an option for quick and highly specific assessment of AR in a rat model of renal transplantation.
    MeSH term(s) Acute Disease ; Animals ; Antibodies/immunology ; CD3 Complex/immunology ; Disease Models, Animal ; Graft Rejection/diagnostic imaging ; Graft Rejection/pathology ; Kidney/diagnostic imaging ; Kidney/pathology ; Kidney Transplantation ; Male ; Microbubbles ; Molecular Imaging ; Rats ; Rats, Inbred Lew ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology ; Ultrasonography
    Chemical Substances Antibodies ; CD3 Complex
    Language English
    Publishing date 2016-02
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 801064-x
    ISSN 1438-8782 ; 1439-0914 ; 1431-4894 ; 0172-4614
    ISSN (online) 1438-8782
    ISSN 1439-0914 ; 1431-4894 ; 0172-4614
    DOI 10.1055/s-0034-1385796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1572: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Noninvasive Imaging of Acute Renal Allograft Rejection by Ultrasound Detection of Microbubbles Targeted to T-lymphocytes in Rats

    Grabner, A. / Kentrup, D. / Mühlmeister, M. / Pawelski, H. / Biermann, C. / Bettinger, T. / Pavenstädt, H. / Schlatter, E. / Tiemann, K. / Reuter, S.

    Ultraschall in der Medizin - European Journal of Ultrasound

    2015  Volume 37, Issue 01, Page(s) 82–91

    Abstract: ... T-lymphocytes for image-based diagnosis of acute allograft rejection (AR) established in a rat renal ... rats subjected to acute cyclosporin A toxicity (CSA) (cyclosporine 50 mg/kg BW for 2 days i. p.) served ... and highly specific assessment of AR in a rat model of renal transplantation. ...

    Abstract Purpose: We propose CD3-antibody-mediated contrast-enhanced ultrasonography using human T-lymphocytes for image-based diagnosis of acute allograft rejection (AR) established in a rat renal transplantation model.
    Materials and Methods: : 15 minutes after tail vein injection of 30 × 10 6 human T-lymphocytes, contrast media/microbubbles conjugated with an anti-human CD3 antibody was applied to uni-nephrectomized 10-week-old allogeneically transplanted male rats (Lewis-Brown Norway (LBN) to Lewis, aTX) and ultrasound was performed to investigate the transplanted kidney as well as the native kidney. In vivo results were confirmed via immunohistochemical stainings of CD3 after post mortem dissection. Syngeneically transplanted rats (LBN to LBN, sTX), rats with ischemia/reperfusion injury (IRI, 45 min. warm ischemia), and rats subjected to acute cyclosporin A toxicity (CSA) (cyclosporine 50 mg/kg BW for 2 days i. p.) served as controls.
    Results: Accumulation of human T-lymphocytes was clearly detected by antibody-mediated sonography und was significantly increased in allografts undergoing AR (5.41 ± 1.32 A. U.) when compared to native control kidneys (0.70 ± 0.08 A. U.). CD3 signal intensity was low in native kidneys, sTX (0.99 ± 0.30 A. U.), CSA (0.10 ± 0.02 A. U.) and kidneys with IRI (0.46 ± 0.29 A. U.). Quantification of the ultrasound signal correlated significantly with the T-cell numbers obtained by immunohistochemical analysis (R2 = 0.57).
    Conclusion: Contrast-enhanced sonography using CD3-antibodies is an option for quick and highly specific assessment of AR in a rat model of renal transplantation.
    Keywords diagnostic radiology ; ultrasound ; molecular imaging ; microbubbles ; transplantation
    Language English
    Publishing date 2015-04-28
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 801064-x
    ISSN 1438-8782 ; 0172-4614 ; 1439-0914 ; 1431-4894
    ISSN (online) 1438-8782
    ISSN 0172-4614 ; 1439-0914 ; 1431-4894
    DOI 10.1055/s-0034-1385796
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1572: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Renal allografts: evaluation by MR imaging.

    Hricak, H / Terrier, F / Demas, B E

    Radiology

    1986  Volume 159, Issue 2, Page(s) 435–441

    Abstract: ... allograft rejection (27/29). No abnormalities on on MR images were observed in allografts compromised ... reflecting a long T1 relaxation time for cortex, was found to be the most consistent sign of acute renal ... by cyclosporin nephrotoxicity. Hydronephrosis of the renal allograft was easily diagnosed with MR. Perirenal ...

    Abstract The value of magnetic resonance (MR) imaging in assessing renal transplants was prospectively studied in 45 patients with 46 allografts. Four allografts were imaged at two different times, and separate diagnoses were given for both examinations. Therefore, this study was based on 50 proved diagnoses: nine normally functioning allografts, four allografts with acute tubular necrosis (ATN), 29 with acute rejection, one with chronic rejection, five with cyclosporin nephrotoxicity, and two with local inflammation secondary to adjacent abscess. Twenty-seven of the allografts had concomitant fluid collections. Normal renal structures with preservation of corticomedullary contrast (CMC) on T1-weighted images were demonstrated in all the normally functioning allografts. Decreased or absent CMC on T1-weighted images, reflecting a long T1 relaxation time for cortex, was found to be the most consistent sign of acute renal allograft rejection (27/29). No abnormalities on on MR images were observed in allografts compromised by cyclosporin nephrotoxicity. Hydronephrosis of the renal allograft was easily diagnosed with MR. Perirenal abscess (three cases) and perirenal hematomas (five cases), because of their higher MR signal intensity on T1-weighted images (TR = 0.5 sec, TE = 28 msec), could be differentiated from clinically insignificant postoperative fluid seromas (seven cases), lymphoceles (11 cases), and urinoma (one case).
    MeSH term(s) Adult ; Body Fluids ; Cyclosporins/adverse effects ; Female ; Graft Rejection ; Humans ; Hydronephrosis/diagnosis ; Hydronephrosis/etiology ; Kidney/drug effects ; Kidney/pathology ; Kidney Transplantation ; Kidney Tubular Necrosis, Acute/diagnosis ; Kidney Tubular Necrosis, Acute/etiology ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged ; Postoperative Complications/diagnosis ; Prospective Studies
    Chemical Substances Cyclosporins
    Language English
    Publishing date 1986-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiology.159.2.3515420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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