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  1. Article: COVID-19 and liver disease: An update.

    Téllez, Luis / Martín Mateos, Rosa María

    Gastroenterologia y hepatologia

    2020  Volume 43, Issue 8, Page(s) 472–480

    Abstract: ... the pandemic has also negatively impacted patients with liver disease who have not contracted COVID-19 ... in the treatment, diagnosis and follow-up of patients with liver disease, which will surely have negative ... The impact of the virus on the liver is not well known, but in patients with chronic liver disease, mostly ...

    Title translation Actualización en COVID-19 y enfermedad hepática.
    Abstract The SARS-CoV-2 pandemic has proven to be a serious challenge for the Spanish healthcare system. The impact of the virus on the liver is not well known, but in patients with chronic liver disease, mostly in advanced stages, it can critically compromise survival and trigger decompensation. Treatment in this subpopulation is complex due to the potential hepatotoxicity of some of the medicinal products used. Moreover, the pandemic has also negatively impacted patients with liver disease who have not contracted COVID-19, since the reallocation of human and material resources to the care of patients with the virus has resulted in a decrease in the treatment, diagnosis and follow-up of patients with liver disease, which will surely have negative consequences in the near future. Efficient reorganization of hepatology units is a priority to minimise the impact of the pandemic on a population as vulnerable as liver disease patients.
    MeSH term(s) Adenosine Monophosphate/adverse effects ; Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Age Factors ; Alanine/adverse effects ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Antiviral Agents/adverse effects ; Antiviral Agents/therapeutic use ; Betacoronavirus ; Bile Ducts/virology ; COVID-19 ; Chemical and Drug Induced Liver Injury/etiology ; Chronic Disease ; Comorbidity ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Disease Susceptibility ; Gastroenterology/organization & administration ; Health Resources/supply & distribution ; Hepatitis, Chronic/drug therapy ; Hepatitis, Chronic/epidemiology ; Humans ; Immunosuppressive Agents/adverse effects ; Liver/drug effects ; Liver/pathology ; Liver/virology ; Liver Diseases/epidemiology ; Liver Function Tests ; Liver Transplantation ; Obesity/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; Resource Allocation ; Risk Factors ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; Immunosuppressive Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Keywords covid19
    Language Spanish
    Publishing date 2020-07-03
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 632502-6
    ISSN 0210-5705
    ISSN 0210-5705
    DOI 10.1016/j.gastrohep.2020.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Actualización en COVID-19 y enfermedad hepática./ Actualización en COVID-19 y enfermedad hepática./ COVID-19 and liver disease: An update

    Téllez, Luis / Martín Mateos, Rosa María

    Gastroenterol Hepatol

    Abstract: ... the pandemic has also negatively impacted patients with liver disease who have not contracted COVID-19 ... in the treatment, diagnosis and follow-up of patients with liver disease, which will surely have negative ... The impact of the virus on the liver is not well known, but in patients with chronic liver disease, mostly ...

    Abstract The SARS-CoV-2 pandemic has proven to be a serious challenge for the Spanish healthcare system. The impact of the virus on the liver is not well known, but in patients with chronic liver disease, mostly in advanced stages, it can critically compromise survival and trigger decompensation. Treatment in this subpopulation is complex due to the potential hepatotoxicity of some of the medicinal products used. Moreover, the pandemic has also negatively impacted patients with liver disease who have not contracted COVID-19, since the reallocation of human and material resources to the care of patients with the virus has resulted in a decrease in the treatment, diagnosis and follow-up of patients with liver disease, which will surely have negative consequences in the near future. Efficient reorganization of hepatology units is a priority to minimise the impact of the pandemic on a population as vulnerable as liver disease patients.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #621606
    Database COVID19

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  3. Article ; Online: Impact of COVID-19 on the liver and on the care of patients with chronic liver disease, hepatobiliary cancer, and liver transplantation: An updated EASL position paper.

    Marjot, Thomas / Eberhardt, Christiane S / Boettler, Tobias / Belli, Luca S / Berenguer, Marina / Buti, Maria / Jalan, Rajiv / Mondelli, Mario U / Moreau, Richard / Shouval, Daniel / Berg, Thomas / Cornberg, Markus

    Journal of hepatology

    2022  Volume 77, Issue 4, Page(s) 1161–1197

    Abstract: ... data on the impact of COVID-19 on the liver and issues guidance on the care of patients with chronic ... liver disease, hepatobiliary cancer, and previous liver transplantation, as the world continues to deal ... The COVID-19 pandemic has presented a serious challenge to the hepatology community, particularly ...

    Abstract The COVID-19 pandemic has presented a serious challenge to the hepatology community, particularly healthcare professionals and patients. While the rapid development of safe and effective vaccines and treatments has improved the clinical landscape, the emergence of the omicron variant has presented new challenges. Thus, it is timely that the European Association for the Study of the Liver provides a summary of the latest data on the impact of COVID-19 on the liver and issues guidance on the care of patients with chronic liver disease, hepatobiliary cancer, and previous liver transplantation, as the world continues to deal with the consequences of the COVID-19 pandemic.
    MeSH term(s) COVID-19 ; Humans ; Liver Diseases/epidemiology ; Liver Diseases/surgery ; Liver Transplantation ; Neoplasms ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-07-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2022.07.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2027: Show issues Location:
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  4. Article: COVID-19 and MAFLD/NAFLD: An updated review.

    Nowroozi, Ali / Momtazmanesh, Sara / Rezaei, Nima

    Frontiers in medicine

    2023  Volume 10, Page(s) 1126491

    Abstract: ... at higher risk of poor COVID-19 outcomes. Metabolic-associated fatty liver disease (MAFLD) (previously non ... The COVID-19 pandemic is ongoing and places a substantial burden on healthcare systems worldwide ... alcoholic fatty liver disease or NAFLD) is a common metabolic disorder characterized by fat accumulation and ...

    Abstract The COVID-19 pandemic is ongoing and places a substantial burden on healthcare systems worldwide. As we further shed light on different disease characteristics, we identify more and more groups of people at higher risk of poor COVID-19 outcomes. Metabolic-associated fatty liver disease (MAFLD) (previously non-alcoholic fatty liver disease or NAFLD) is a common metabolic disorder characterized by fat accumulation and liver fibrosis. Given its close correlation with metabolic syndrome, an established risk factor for severe COVID-19, it is necessary to investigate its interplay with the novel coronavirus. In this study, we review the available data on COVID-19 prognosis, treatment and prevention options in patients with MAFLD, and the effect that the disease and the pandemic have on MAFLD care. Furthermore, we point out the gaps in the current literature to accentuate the work that needs to be done to improve MAFLD care during the pandemic and beyond.
    Language English
    Publishing date 2023-03-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1126491
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  5. Article ; Online: The radiological findings of COVID-19

    Karacan, Alper / Aksoy, Yakup Ersel / Öztürk, Mehmet Halil

    Turkish journal of medical sciences

    2021  Volume 51, Issue SI-1, Page(s) 3328–3339

    Abstract: ... disease (COVID-19) is constantly updated. Ground glass opacities (GGOs) and consolidation with bilateral ... understand the radiological manifestations of COVID-19.: Materials and methods: Radiological findings ... Results: The typical pulmonary manifestations of COVID-19 pneumonia were determined as GGOs and ...

    Abstract Background/aim: Available information on the radiological findings of the 2019 novel coronavirus disease (COVID-19) is constantly updated. Ground glass opacities (GGOs) and consolidation with bilateral and peripheral distribution have been reported as the most common CT findings, but less typical features can also be identified. According to the reported studies, SARS-CoV-2 infection is not limited to the respiratory system, and it can also affect other organs. Renal dysfunction, gastrointestinal complications, liver dysfunction, cardiac manifestations, and neurological abnormalities are among the reported extrapulmonary features. This review aims to provide updated information for radiologists and all clinicians to better understand the radiological manifestations of COVID-19.
    Materials and methods: Radiological findings observed in SARS-CoV-2 virus infections were explored in detail in PubMed and Google Scholar databases.
    Results: The typical pulmonary manifestations of COVID-19 pneumonia were determined as GGOs and accompanying consolidations that primarily involve the periphery of the bilateral lower lobes. The most common extrapulmonary findings were increased resistance to flow in the kidneys, thickening of vascular walls, fatty liver, pancreas, and heart inflammation findings. However, these findings were not specific and significantly overlapped those caused by other viral diseases, and therefore alternative diagnoses should be considered in patients with negative diagnostic tests.
    Conclusion: Radiological imaging plays a supportive role in the care of patients with COVID-19. Both clinicians and radiologists need to know associated pulmonary and extrapulmonary findings and imaging features to help diagnose and manage the possible complications of the disease at an early stage. They should also be familiar with CT findings in patients with COVID-19 since the disease can be incidentally detected during imaging performed with other indications.
    MeSH term(s) COVID-19/diagnostic imaging ; Humans ; SARS-CoV-2 ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2021-12-17
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.3906/sag-2106-203
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    Zs.A 3242: Show issues Location:
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  6. Article ; Online: Digestive involvement in the Long-COVID syndrome.

    Bogariu, Alina M / Dumitrascu, Dan L

    Medicine and pharmacy reports

    2022  Volume 95, Issue 1, Page(s) 5–10

    Abstract: ... SARS-CoV-2 and COVID-19. Data on gastrointestinal symptoms after 12 weeks were collected and presented ... progressively detected and called Long-COVID. This review aims is to present the updated knowledge ... Observational studies were included. Studies that focus only on acute COVID-19 infection (<4 weeks) were ...

    Abstract Background and aim: The SARS-CoV-2 infection which caused a worldwide epidemic was considered first a lung disease. Later on, it was found that the disease caused by this virus, SARS-CoV-2, can affect most organs, including the digestive system. The long-term effects of this infection are now progressively detected and called Long-COVID. This review aims is to present the updated knowledge of the digestive sequelae after SARS-CoV-2 infection.
    Methods: A search was performed in the main medical literature databases. The following search terms were used: long-covid, gastrointestinal or gastric sequelae SARS-CoV-2 and COVID-19. Data on gastrointestinal symptoms after 12 weeks were collected and presented. Observational studies were included. Studies that focus only on acute COVID-19 infection (<4 weeks) were excluded.
    Results: The main symptoms that can occur in the long term are: diarrhea, nausea, vomiting, abdominal pain, along with increased liver enzymes. Patients with chronic diseases have a higher risk of developing long-term sequelae, but it is not documented that digestive sequelae are influenced by the presence of chronic diseases.
    Conclusions: The SARS-CoV-2 virus can affect any part of the digestive system not only in the acute infection phase but also for longer time, leaving long-term sequelae.
    Language English
    Publishing date 2022-01-31
    Publishing country Romania
    Document type Journal Article ; Review
    ZDB-ID 2974425-8
    ISSN 2668-0572 ; 2602-0807
    ISSN (online) 2668-0572
    ISSN 2602-0807
    DOI 10.15386/mpr-2340
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  7. Article ; Online: Update 2021: COVID-19 aus Sicht der Gastroenterologie.

    Schulz, Christian / Mayerle, Julia / Lerch, Markus M / Malfertheiner, Peter

    Deutsche medizinische Wochenschrift (1946)

    2021  Volume 146, Issue 13-14, Page(s) 891–893

    Abstract: ... of gastrointestinal symptoms in COVID 19, its role for prognosis and specific risks in relation to immunosuppressive ... During COVID 19 pandemic patients typically present with respiratory symptoms ... therapies and underlying diseases. ...

    Title translation Update 2021: COVID-19 from the perspective of gastroenterology.
    Abstract During COVID 19 pandemic patients typically present with respiratory symptoms. However, in a significant number of patients the gastrointestinal tract is also involved in the disease. Up to 20 % of patients suffering from gastrointestinal symptoms. New insights in pathophysiological aspects might open new therapeutic concepts. This up-date includes current data regarding epidemiology of gastrointestinal symptoms in COVID 19, its role for prognosis and specific risks in relation to immunosuppressive therapies and underlying diseases.
    MeSH term(s) COVID-19/complications ; Gastrointestinal Diseases/epidemiology ; Gastrointestinal Diseases/etiology ; Gastrointestinal Diseases/therapy ; Humans ; Immunosuppression/adverse effects ; Liver Diseases/virology ; Pancreatic Diseases/virology ; Prevalence ; Prognosis ; Risk Factors ; SARS-CoV-2/pathogenicity ; SARS-CoV-2/physiology
    Language German
    Publishing date 2021-07-13
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1449-4054
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  8. Article: Impact and management of COVID-19 in liver transplant candidates and recipients.

    Liava, Christina / Ouranos, Konstantinos / Chatziioannou, Anthi / Kamenidou, Irene / Kofinas, Athanasios / Vasileiadou, Stella / Antoniadis, Nikolaos / Katsanos, Georgios / Akriviadis, Evangelos / Sinakos, Emmanouil

    Annals of gastroenterology

    2023  Volume 36, Issue 5, Page(s) 477–489

    Abstract: ... of serious COVID-19 infection in this population. According to the Centers for Disease Control and Prevention ... patients with liver disease are considered at higher risk for severe COVID-19 infection. In March 2020 ... and the socioeconomic status of a considerable number of countries. The emergence of COVID-19 has also ...

    Abstract The COVID-19 outbreak has had severe consequences for global public health, medical communities, and the socioeconomic status of a considerable number of countries. The emergence of COVID-19 has also significantly impacted the world of liver transplantation (LT). Studies from transplantation centers around the world have shown that LTs during the COVID-19 pandemic have been restricted because of the high risk of serious COVID-19 infection in this population. According to the Centers for Disease Control and Prevention, patients with liver disease are considered at higher risk for severe COVID-19 infection. In March 2020, the American Association for the Study of Liver Diseases recommended that LT should be limited to emergency cases. The COVID-19 treatment guidelines published by the National Institutes of Health are being constantly updated according to new epidemiology trends and treatment regimens. Immunocompromised patients have a higher risk of developing severe disease or death from COVID-19 compared with the general population. In this review, we summarize the available evidence regarding treatment guidelines and considerations for the evaluation and management of LT candidates and recipients in the era of COVID-19. In addition, we present data regarding COVID-19 among LT patients in our local transplantation center.
    Language English
    Publishing date 2023-07-03
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2032850-3
    ISSN 1108-7471
    ISSN 1108-7471
    DOI 10.20524/aog.2023.0815
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    Zs.A 2455: Show issues Location:
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  9. Article: Prevalence and Impact of Gastrointestinal Manifestations in COVID-19 Patients: A Systematic Review.

    Hossain, Bassam / Malik, Fahad / Khan, Ali / Abidi, Mohammad / Marhaba, Ali / Oranu, Amanke / Shumeyko, Mark / Hila, Amine / Banks, Lesli / Patel, Owais A / Nawaz, Marrium / Shaikh, Shehryar / Nadeem, Hafsa / Qazi, Shoreh

    Journal of community hospital internal medicine perspectives

    2023  Volume 13, Issue 3, Page(s) 39–54

    Abstract: ... of such symptoms in COVID-19 patients which can potentially influence the disease prognosis and outcome ... as an important characteristic in COVID-19 patients. Hence, precise and targeted documentation of GI symptoms and ... in COVID-19 patients along with the disease prognosis. A meta-analysis of studies having adequate ...

    Abstract Background and objective: The aim of this study is to systematically analyze and summarize the implications of COVID-19 on the digestive system by quantitatively evaluating the prevalence of gastrointestinal symptoms such as nausea, vomiting, abdominal pain, constipation, diarrhea, anorexia. reported in COVID-19 cases. We simultaneously investigated other variables to determine the association of such symptoms in COVID-19 patients which can potentially influence the disease prognosis and outcome. This systematic review presents an updated literature on the issue as it requires more scientific discussion in order to better inform the medical community and authorities so that appropriate measures can be taken to control the virus outbreak.
    Methods: MEDLINE database was searched to identify relevant articles. Data was analyzed and synthesized from the 16 eligible studies which exclusively reported GI symptoms in COVID-19 patients along with the disease prognosis. A meta-analysis of studies having adequate information regarding the prevalence of specific GI symptoms in association with other relevant independent variables was performed.
    Results: From the search strategy, we identified 16 articles which fit our eligibility criteria comprising of 10 cross-sectional studies, 2 cohort study, 1 RCT and 3 observational studies. From these pooled studies, 6 articles exclusively talked about COVID-19 patients in which GI symptoms were reported and adequately discussed. In a total of 3646 patients, GI symptoms were documented in (16.2%-10.1%) patients. The most prevalent GI symptom was diarrhea (47%) but the most common clinical manifestation reported was fever (77.4%). Among the adult patients, hypertension (11.6%) was the most frequently reported comorbidity. Presence of viral RNA in stool sample was noted in 16.7% patients with GI symptom. In patients who complained of having GI symptoms, an abnormal liver function was largely observed, with an elevated ALT level in (10.9%) and an elevated AST in (8.8%) of the patients. Evidence of vertical transmission (14.2%) was reported in one study which highlights the extent and mode of viral transmission. It was observed that a great majority of the patients in the 6 studies reporting specifically on patients with GI symptoms were on antiviral therapy (68.6%) as the standard disease management protocol but the eventual disease outcome as in this case died (8.4%), discharged (45.6%) was not linked to just one therapeutic factor but other indicators of disease severity such as positive chest CT findings (87.82%) have led to a poor disease prognosis which was noted in (28.9%) severe patients with GI symptoms compared to (71.1%) non-severe COVID-19 patients with GI symptom.
    Conclusion: Presence of GI symptoms in COVID-19 patients has shown to have a positive association with the poor disease prognosis likely as a result of direct viral toxicity. It is important for the physicians to recognize digestive symptoms as an important characteristic in COVID-19 patients. Hence, precise and targeted documentation of GI symptoms and viral stool sample investigations should be performed in order to understand the rapidly evolving disease symptomology.
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2616884-4
    ISSN 2000-9666
    ISSN 2000-9666
    DOI 10.55729/2000-9666.1145
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  10. Article ; Online: Awaiting a cure for COVID-19: therapeutic approach in patients with different severity levels of COVID-19.

    Alfano, Gaetano / Morisi, Niccolò / Frisina, Monica / Ferrari, Annachiara / Fontana, Francesco / Tonelli, Roberto / Franceschini, Erica / Meschiari, Marianna / Donati, Gabriele / Guaraldi, Giovanni

    Le infezioni in medicina

    2022  Volume 30, Issue 1, Page(s) 11–21

    Abstract: ... of the disease that continues to cause death and comorbidity worldwide. Current treatment of COVID-19 patients is ... of medical care for all patients with COVID-19 is pivotal to improving disease outcomes and restoring ... patients. However, unvaccinated patients and non-responders to the COVID-19 vaccine are at risk of shortand ...

    Abstract COVID-19 is an unpredictable infectious disease caused by SARS-CoV-2. The development of effective anti-COVID-19 vaccines has enormously minimized the risk of severe illness in most immunocompetent patients. However, unvaccinated patients and non-responders to the COVID-19 vaccine are at risk of shortand long-term consequences. In these patients, the outcome of COVID-19 relies on an interplay of multiple factors including age, immunocompetence, comorbidities, inflammatory response triggered by the virus as well as the virulence of SARS-CoV-2 variants. Generally, COVID-19 is asymptomatic or mildly symptomatic in young people, but it may manifest with respiratory insufficiency requiring mechanical ventilation in certain susceptible groups of patients. Furthermore, severe SARS-CoV-2 infection induces multiorgan failure syndrome by affecting liver, kidney heart and nervous system. Since December 2019, multiple drugs have been tested to treat COVID-19, but only a few have been proven effective to mitigate the course of the disease that continues to cause death and comorbidity worldwide. Current treatment of COVID-19 patients is essentially based on the administration of supportive oxygen therapy and the use of specific drugs such as steroids, anticoagulants, antivirals, anti-SARS-CoV-2 antibodies and immunomodulators. However, the rapid spread of new variants and the release of new data coming from the numerous ongoing clinical trials have created the conditions for maintaining a continuous updating of the therapeutic management of COVID-19 patients. Furthermore, we believe that a well-established therapeutic strategy along with the continuum of medical care for all patients with COVID-19 is pivotal to improving disease outcomes and restoring healthcare care fragmentation caused by the pandemic. This narrative review, focusing on the therapeutic management of COVID-19 patients, aimed to provide an overview of current therapies for (i) asymptomatic or mildly/moderate symptomatic patients, (ii) hospitalized patients requiring low-flow oxygen, (iii) high-flow oxygen and (iv) mechanical ventilation.
    Language English
    Publishing date 2022-03-01
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2041081-5
    ISSN 2532-8689 ; 1124-9390
    ISSN (online) 2532-8689
    ISSN 1124-9390
    DOI 10.53854/liim-3001-2
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