Article ; Online: MicroRNA-570 promotes lung carcinoma proliferation through targeting tumor suppressor KLF9.
International journal of clinical and experimental pathology
2015 Volume 8, Issue 3, Page(s) 2829–2834
Abstract: ... our results suggest a previously unknown miR-570/KLF9 molecular network controlling lung carcinoma progression. ... a tumor suppressor gene, was identified as a potential target of miR-570 in lung cancer cells. Indeed, miR-570 ... of lung carcinoma. In the present study, the expression and functions of miR-570 were investigated ...
| Abstract | Increasing studies have shown that MicroRNAs (miRNAs) play critical roles in the progression of lung carcinoma. In the present study, the expression and functions of miR-570 were investigated. We found that miR-570 was significantly up-regulated in lung cancer tissues, compared with adjacent non-cancerous tissues. In vitro studies further showed that miR-570 mimics could promote, while its antisense oligos inhibit cell proliferation and invasion. At the molecular level, krüppel-like factor 9 (KLF9), a tumor suppressor gene, was identified as a potential target of miR-570 in lung cancer cells. Indeed, miR-570 could negatively regulate protein levels of KLF9 through targeting its 3'-untranslated region. Taken together, our results suggest a previously unknown miR-570/KLF9 molecular network controlling lung carcinoma progression. |
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| MeSH term(s) | Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Humans ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasm Invasiveness ; Oligonucleotides, Antisense/genetics ; Oligonucleotides, Antisense/metabolism ; Signal Transduction ; Transfection ; Up-Regulation |
| Chemical Substances | KLF9 protein, human ; Kruppel-Like Transcription Factors ; MIRN570 microRNA, human ; MicroRNAs ; Oligonucleotides, Antisense |
| Language | English |
| Publishing date | 2015 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2418306-4 |
| ISSN | 1936-2625 ; 1936-2625 |
| ISSN (online) | 1936-2625 |
| ISSN | 1936-2625 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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