Article ; Online: Effectiveness of magnesium sulfate as initial treatment of acute severe asthma in children, conducted in a tertiary-level university hospital: a randomized, controlled trial.
Archivos argentinos de pediatria
2012 Volume 110, Issue 4, Page(s) 291–296
Abstract: ... of intravenous magnesium sulfate for the treatment of pediatric patients with acute severe asthma exacerbations ... treatment of acute asthma exacerbation. Group B: treatment protocol with magnesium sulphate for acute severe ... 2011 at Hospital Universitario Austral. Children with acute severe asthma admitted to the emergency ...
| Abstract | Introduction: Magnesium sulfate is a calcium antagonist that inhibits bronchial smooth muscle contraction promoting bronchodilation. It is used for the management of acute severe asthma in children; however most of the studies have been performed in adults. Objective: To evaluate the effectiveness of intravenous magnesium sulfate for the treatment of pediatric patients with acute severe asthma exacerbations. Population and methods: A clinical, randomized, controlled trial was conducted between March 2006 and March 2011 at Hospital Universitario Austral. Children with acute severe asthma admitted to the emergency department were randomized into two groups. Group A (control group): standard protocol for the initial treatment of acute asthma exacerbation. Group B: treatment protocol with magnesium sulphate for acute severe asthma exacerbation. The primary outcome was the requirement of invasive or non invasive mechanical ventilation support. Results: One hundred and forty three patients randomized into 2 groups were analyzed. The treatment group included 76 patients receiving magnesium sulfate within the first hour of the initiation of rescue treatment at the hospital, and the control group included 67 patients not treated with magnesium sulphate. Among the patients in the control group, 33% (n= 22) required mechanical ventilation support, compared to only 5% (n= 4) of the patients in the treatment group (p = 0.001). Conclusions: Intravenous infusion of magnesium sulfate during the first hour of hospitalization in patients with acute severe asthma significantly reduced the percentage of children who required mechanical ventilation support. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Acute Disease ; Adolescent ; Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Child ; Child, Preschool ; Disease Progression ; Female ; Hospitals, University ; Humans ; Magnesium Sulfate/therapeutic use ; Male ; Respiration, Artificial ; Tertiary Care Centers | |||||
| Chemical Substances | Anti-Asthmatic Agents ; Magnesium Sulfate (7487-88-9) | |||||
| Language | Spanish | |||||
| Publishing date | 2012-06-28 | |||||
| Publishing country | Argentina | |||||
| Document type | Journal Article ; Randomized Controlled Trial | |||||
| ZDB-ID | 424449-7 | |||||
| ISSN | 1668-3501 ; 0325-0075 ; 0004-0487 | |||||
| ISSN (online) | 1668-3501 | |||||
| ISSN | 0325-0075 ; 0004-0487 | |||||
| DOI | 10.5546/aap.2012.eng.291 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.B 251: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.