Article ; Online: Prolonged elevation of D-dimer levels in convalescent COVID-19 patients is independent of the acute phase response.
Journal of thrombosis and haemostasis : JTH
2021 Volume 19, Issue 4, Page(s) 1064–1070
Abstract: ... assessed.: Results: Increased D-dimer levels (>500 ng/ml) were observed in 25.3% patients up to 4 months ... Interestingly, we observed that 29% (n = 11) of patients with elevated convalescent D-dimers had been managed ... in COVID-19 patients who had required hospital admission and in patients aged more than 50 years (p < .001 ...
| Abstract | Background: Persistent fatigue, breathlessness, and reduced exercise tolerance have been reported following acute COVID-19 infection. Although immuno-thrombosis has been implicated in acute COVID-19 pathogenesis, the biological mechanisms underpinning long COVID remain unknown. We hypothesized that pulmonary microvascular immuno-thrombosis may be important in this context. Methods: One hundred fifty COVID-19 patients were reviewed at St James's Hospital Dublin between May and September 2020 at a median of 80.5 (range 44-155) days after initial diagnosis. These included patients hospitalized during initial illness (n = 69) and others managed entirely as out-patients (n = 81). Clinical examination, chest x-ray, and 6-min walk tests were performed. In addition, a range of coagulation and inflammatory markers were assessed. Results: Increased D-dimer levels (>500 ng/ml) were observed in 25.3% patients up to 4 months post-SARS-CoV-2 infection. On univariate analysis, elevated convalescent D-dimers were more common in COVID-19 patients who had required hospital admission and in patients aged more than 50 years (p < .001). Interestingly, we observed that 29% (n = 11) of patients with elevated convalescent D-dimers had been managed exclusively as out-patients during their illness. In contrast, other coagulation (prothrombin time, activated partial thromboplastin time, fibrinogen, platelet count) and inflammation (C-reactive protein, interleukin-6, and sCD25) markers had returned to normal in >90% of convalescent patients. Conclusions: Elucidating the biological mechanisms responsible for sustained D-dimer increases may be of relevance in long COVID pathogenesis and has implications for clinical management of these patients. |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| MeSH term(s) | Acute-Phase Reaction ; Aged ; COVID-19/blood ; COVID-19/rehabilitation ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Humans ; Male ; Middle Aged ; SARS-CoV-2 | ||||||||||
| Chemical Substances | Fibrin Fibrinogen Degradation Products ; fibrin fragment D | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2021-03-08 | ||||||||||
| Publishing country | England | ||||||||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 2112661-6 | ||||||||||
| ISSN | 1538-7836 ; 1538-7933 | ||||||||||
| ISSN (online) | 1538-7836 | ||||||||||
| ISSN | 1538-7933 | ||||||||||
| DOI | 10.1111/jth.15267 | ||||||||||
| Shelf mark |
|
||||||||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 5805: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
|||
| Zs.MO 295: Show issues |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.