Article: Complement inhibition by anti-C5 antibodies--from bench to bedside and back again.
2007 Volume 137, Issue 29-30, Page(s) 413–417
Abstract: ... of the clinical treatment routine. With blocking antibodies against complement C5 a new generation ... regulatory functions. Although many experimental studies have demonstrated that complement inhibition ... might be advantageous in a number of different human diseases, complement inhibition is still not part ...
| Abstract | The complement system is an important part of the innate immune system with pro-inflammatory and regulatory functions. Although many experimental studies have demonstrated that complement inhibition might be advantageous in a number of different human diseases, complement inhibition is still not part of the clinical treatment routine. With blocking antibodies against complement C5 a new generation of therapeutic complement inhibitors has now been investigated in some human diseases. This review gives an overview on the new complement inhibitors and the results obtained in clinical studies thus far. |
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| MeSH term(s) | Amino Acid Sequence ; Antibodies, Blocking ; Antibodies, Monoclonal ; Binding, Competitive ; Complement C5/antagonists & inhibitors ; Complement C5/immunology ; Complement C5a ; Complement Inactivator Proteins/physiology ; Complement Membrane Attack Complex ; Complement System Proteins/physiology ; Humans ; Immunoglobulin Fragments/pharmacology ; Recombinant Fusion Proteins/pharmacology |
| Chemical Substances | Antibodies, Blocking ; Antibodies, Monoclonal ; Complement C5 ; Complement Inactivator Proteins ; Complement Membrane Attack Complex ; Immunoglobulin Fragments ; Recombinant Fusion Proteins ; Complement C5a (80295-54-1) ; Complement System Proteins (9007-36-7) |
| Language | English |
| Publishing date | 2007-06-13 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 2036179-8 |
| ISSN | 1424-3997 ; 1424-7860 |
| ISSN (online) | 1424-3997 |
| ISSN | 1424-7860 |
| DOI | 10.4414/smw.2007.11792 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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