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  1. Article ; Online: Imaging in support of the clinical diagnoses of COVID-19 and multisystem inflammatory syndrome in children.

    Trout, Andrew T / Westra, Sjirk J

    Pediatric radiology

    2021  Volume 51, Issue 5, Page(s) 693–694

    MeSH term(s) COVID-19 ; Child ; Diagnostic Imaging ; Humans ; SARS-CoV-2 ; Syndrome ; Systemic Inflammatory Response Syndrome
    Language English
    Publishing date 2021-02-17
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-021-04999-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The importance of heart and brain imaging in children and adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C).

    Mavrogeni, Sophie I / Kolovou, Genovefa / Tsirimpis, Vasileios / Kafetzis, Dimitrios / Tsolas, Georgios / Fotis, Lampros

    Rheumatology international

    2021  Volume 41, Issue 6, Page(s) 1037–1044

    Abstract: Multisystem Inflammatory Syndrome in Children (MIS-C) recently reported in a minority of children ... In contrast to acute COVID-19 infection, which is usually mild in children, 68% of patients with MIS-C ... organs, such as heart and brain. Clinical awareness, application of innovative, high technology imaging ...

    Abstract Multisystem Inflammatory Syndrome in Children (MIS-C) recently reported in a minority of children affected by SARS-CoV-2, mimics Kawasaki disease (KD), a medium vessel vasculitis of unknown cause. In contrast to acute COVID-19 infection, which is usually mild in children, 68% of patients with MIS-C will need intensive care unit. Myocarditis and coronary artery ectasia/aneurysm are included between the main cardiovascular complications in MIS-C. Therefore, close clinical assessment is need it both at diagnosis and during follow-up. Echocardiography is the cornerstone modality for myocardial function and coronary artery evaluation in the acute phase. Cardiovascular magnetic resonance (CMR) detects diffuse myocardial inflammation including oedema/fibrosis, myocardial perfusion and coronary arteries anatomy during the convalescence and in adolescents, where echocardiography may provide inadequate images. Brain involvement in MIS-C is less frequent compared to cardiovascular disease. However, it is not unusual and should be monitored by clinical evaluation and brain magnetic resonance (MRI), as we still do not know its effect in brain development. Brain MRI in MIS-C shows T2-hyperintense lesions associated with restricted diffusion and bilateral thalamic lesions. To conclude, MIS-C is a multisystem disease affecting many vital organs, such as heart and brain. Clinical awareness, application of innovative, high technology imaging modalities and advanced treatment protocols including supportive and anti-inflammatory medication will help physicians to prevent the dreadful complications of MIS-C.
    MeSH term(s) Adolescent ; Brain/diagnostic imaging ; COVID-19/diagnosis ; COVID-19/physiopathology ; Child ; Child, Preschool ; Coronary Angiography ; Echocardiography ; Electrocardiography ; Heart/diagnostic imaging ; Humans ; Infant ; Infant, Newborn ; Magnetic Resonance Imaging ; Neuroimaging ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/physiopathology
    Language English
    Publishing date 2021-04-17
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-021-04845-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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