Article: [Pathogenic aspects of influenza during the epidemics caused by A/H1N1v virus in 2009-2010 according autopsy data].
2011 Volume 73, Issue 6, Page(s) 21–25
Abstract: ... lethal cases of influenza in Saint-Petersburg and Leningrad region during the epidemics 2009/2010 ... Immunohistochemical analysis of lungs, heart and brain using monoclonal sera to HA and HP proteins of influenza virus ... the "influenza cells", previously described by A. V Zinserling the cells with enlarge light nuclei were observed ...
| Abstract | The paper is based upon the results of clinic-pathological and virological correlations in 29 lethal cases of influenza in Saint-Petersburg and Leningrad region during the epidemics 2009/2010. Immunohistochemical analysis of lungs, heart and brain using monoclonal sera to HA and HP proteins of influenza virus, virological and morphological analysis of experimental influenza in mice infected by A/WSN/33 (HIN1) and A/California/07/09 (H1N1) viruses had been carried out. In the majority of investigated strains was proved the amino acid mutation with replacement D222G. The replication of virus was demonstrated at the late stages of diseases, but the desquamation of respiratory epithelium and cytoproliferative weren't found out. Besides the "influenza cells", previously described by A. V Zinserling the cells with enlarge light nuclei were observed. Patients with influenza died from respiratory distress syndrome with minimal bacterial infection. We've established that H1N1 virus not only damages the cells of respiratory epithelium and alveolar macrophages but it can injure endothelium of different organs and neuroglia. The questions which have to be discussed are listed. |
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| MeSH term(s) | Adolescent ; Adult ; Animals ; Autopsy ; Brain/pathology ; Brain/virology ; Female ; Heart/virology ; Humans ; Immunohistochemistry ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H1N1 Subtype/isolation & purification ; Influenza A Virus, H1N1 Subtype/physiology ; Influenza, Human/mortality ; Influenza, Human/pathology ; Influenza, Human/virology ; Lung/pathology ; Lung/virology ; Male ; Mice ; Middle Aged ; Myocardium/pathology ; Polymerase Chain Reaction ; Respiratory Distress Syndrome, Adult/etiology ; Respiratory Distress Syndrome, Adult/mortality ; Respiratory Distress Syndrome, Adult/pathology ; Respiratory Distress Syndrome, Adult/virology ; Russia/epidemiology ; Virus Replication ; Young Adult | |||||
| Language | Russian | |||||
| Publishing date | 2011-11 | |||||
| Publishing country | Russia (Federation) | |||||
| Document type | English Abstract ; Journal Article | |||||
| ZDB-ID | 127285-8 | |||||
| ISSN | 0004-1955 | |||||
| ISSN | 0004-1955 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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