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  1. Article: Rehabilitation in adult post-COVID-19 patients in post-acute care with Therapeutic Exercise.

    Udina, C / Ars, J / Morandi, A / Vilaró, J / Cáceres, C / Inzitari, M

    The Journal of frailty & aging

    2021  Volume 10, Issue 3, Page(s) 297–300

    Abstract: ... for post-COVID-19 rehabilitation in a post-acute care facility. A 30-minute daily multicomponent ... COVID-19 patients may experience disability related to Intensive Care Unit (ICU) admission or due ... to immobilization. We assessed pre-post impact on physical performance of multi-component therapeutic exercise ...

    Abstract COVID-19 patients may experience disability related to Intensive Care Unit (ICU) admission or due to immobilization. We assessed pre-post impact on physical performance of multi-component therapeutic exercise for post-COVID-19 rehabilitation in a post-acute care facility. A 30-minute daily multicomponent therapeutic exercise intervention combined resistance, endurance and balance training. Outcomes: Short Physical Performance Battery; Barthel Index, ability to walk unassisted and single leg stance. Clinical, functional and cognitive variables were collected. We included 33 patients (66.2±12.8 years). All outcomes improved significantly in the global sample (p<0.01). Post-ICU patients, who were younger than No ICU ones, experienced greater improvement in SPPB (4.4±2.1 vs 2.5±1.7, p<0.01) and gait speed (0.4±0.2 vs 0.2±0.1 m/sec, p<0.01). In conclusion, adults surviving COVID-19 improved their functional status, including those who required ICU stay. Our results emphasize the need to establish innovative rehabilitative strategies to reduce the negative functional outcomes of COVID-19.
    MeSH term(s) COVID-19 ; Exercise ; Exercise Therapy ; Humans ; SARS-CoV-2 ; Subacute Care
    Language English
    Publishing date 2021-06-04
    Publishing country France
    Document type Journal Article
    ZDB-ID 2856228-8
    ISSN 2273-4309 ; 2260-1341
    ISSN (online) 2273-4309
    ISSN 2260-1341
    DOI 10.14283/jfa.2021.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Long COVID and rehabilitation.

    Chuang, Hung-Jui / Lin, Chia-Wei / Hsiao, Ming-Yen / Wang, Tyng-Guey / Liang, Huey-Wen

    Journal of the Formosan Medical Association = Taiwan yi zhi

    2023  Volume 123 Suppl 1, Page(s) S61–S69

    Abstract: ... of management of long COVID, can be conducted with different modules, including telerehabilitation. Post ... The large number of post-COVID survivors has drawn attention to the management of post-COVID condition ... for long COVID patients. Dyspnea, chronic cough, and fatigue are the most commonly reported symptoms ...

    Abstract Coronavirus disease 2019 (COVID-19) has caused tremendous morbidity and mortality worldwide. The large number of post-COVID survivors has drawn attention to the management of post-COVID condition, known as long COVID. This review examines current knowledge of long COVID, regarding its epidemiology, mechanism, and clinical presentations in both adults and children. We also review the rehabilitation principles, modules, and effects, and share Taiwan's efforts to provide a top-down, nationwide care framework for long COVID patients. Dyspnea, chronic cough, and fatigue are the most commonly reported symptoms in the first 6 months after infection, but cognitive impairment and psychological symptoms may persist beyond this time. Several possible mechanisms behind these symptoms were proposed, but remained unconfirmed. These symptoms negatively impact individuals' function, activities, participation and quality of life. Rehabilitation is a key element of management to achieve functional improvement. Early management should start with comprehensive evaluation and identification of red flags. Exercise-based therapy, an essential part of management of long COVID, can be conducted with different modules, including telerehabilitation. Post-exertional symptom exacerbation and orthostatic hypotension should be carefully monitored during exercise. Randomized control trials with a large sample size are needed to determine the optimal timing, dosage, and modules.
    MeSH term(s) Adult ; Child ; Humans ; Post-Acute COVID-19 Syndrome ; COVID-19 ; Quality of Life ; Exercise Therapy ; Dyspnea
    Language English
    Publishing date 2023-04-13
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2096659-3
    ISSN 1876-0821 ; 0929-6646
    ISSN (online) 1876-0821
    ISSN 0929-6646
    DOI 10.1016/j.jfma.2023.03.022
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  3. Article ; Online: Effect of home-based pulmonary rehabilitation on exercise capacity in post COVID-19 patients: a randomized controlled trail.

    Elyazed, Tamer I Abo / Alsharawy, Laila A / Salem, Shaimaa E / Helmy, Nesma A / El-Hakim, Ahmed Abd El-Moneim Abd

    Journal of neuroengineering and rehabilitation

    2024  Volume 21, Issue 1, Page(s) 40

    Abstract: ... on exercise capacity in patients with post COVID-19 syndrome.: Methods: The study was designed ... pulmonary rehabilitation (HBPR) for patients with post COVID-19 syndrome is effective and has a potential ... an adjunctive, applicable, and low-cost therapy for patients with post COVID-19 syndrome.: Trial registration ...

    Abstract Background: Coronavirus 2019 (COVID-19) is an epidemic condition that compromises various consequences. The goal of this study was to investigate the effect of home-based pulmonary rehabilitation on exercise capacity in patients with post COVID-19 syndrome.
    Methods: The study was designed as a randomized control trial. A total of sixty-eight patients with post COVID-19 syndrome complaining of fatigue, dyspnea, and exercise intolerance participated in this study. Their ages ranged from 40 to 70 years old. The patients were randomly classified into two equal groups. The control group received usual medical care only, whereas the rehabilitation group received a selected home-based pulmonary rehabilitation exercise program plus the same usual medical care. The Physical Fitness Index (PFI), Chalder fatigue index, SF-36 questionnaire, dyspnea scale, and six-minute walk test (6 MWT) were measured before and after 12 weeks of intervention.
    Results: The rehabilitation group showed a significant lower mean of Chalder fatigue (11.1 ± 0.94) and a higher mean of 6MWT (439.7 ± 25.3) and PFI (52.3 ± 10.2), in addition to a higher mean of the SF-36 Questionnaire (66.4 ± 3.7) and a significant improvement of dyspnea in the mMRC score (26.7%), grade 2, (63.3%), grade 1 (10%), and grade 0 with a p-value < 0.001 when compared to the control group.
    Conclusion: Home-based pulmonary rehabilitation (HBPR) for patients with post COVID-19 syndrome is effective and has a potential direct influence on exercise capacity, fatigue, dyspnea, and quality of life. HBPR could be considered an adjunctive, applicable, and low-cost therapy for patients with post COVID-19 syndrome.
    Trial registration: The study was registered in Pan African Clinical Trial Registry as a clinical trial ID (PACTR202111640499636), November 2021.
    MeSH term(s) Adult ; Aged ; Humans ; Middle Aged ; COVID-19/epidemiology ; Dyspnea/etiology ; Dyspnea/rehabilitation ; Exercise Therapy ; Exercise Tolerance ; Post-Acute COVID-19 Syndrome ; Quality of Life
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2164377-5
    ISSN 1743-0003 ; 1743-0003
    ISSN (online) 1743-0003
    ISSN 1743-0003
    DOI 10.1186/s12984-024-01340-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Rehabilitation Interventions for Physical Capacity and Quality of Life in Adults With Post-COVID-19 Condition: A Systematic Review and Meta-Analysis.

    Pouliopoulou, Dimitra V / Macdermid, Joy C / Saunders, Emily / Peters, Sue / Brunton, Laura / Miller, Erin / Quinn, Kieran L / Pereira, Tiago V / Bobos, Pavlos

    JAMA network open

    2023  Volume 6, Issue 9, Page(s) e2333838

    Abstract: Importance: Current rehabilitation guidelines for patients with post-COVID-19 condition (PCC) are ... to identify potentially relevant studies included long-covid, post-covid, sequelae, exercise therapy ... rehabilitation interventions with either placebo, usual care, waiting list, or control in patients with PCC ...

    Abstract Importance: Current rehabilitation guidelines for patients with post-COVID-19 condition (PCC) are primarily based on expert opinions and observational data, and there is an urgent need for evidence-based rehabilitation interventions to support patients with PCC.
    Objective: To synthesize the findings of existing studies that report on physical capacity (including functional exercise capacity, muscle function, dyspnea, and respiratory function) and quality of life outcomes following rehabilitation interventions in patients with PCC.
    Data sources: A systematic electronic search was performed from January 2020 until February 2023, in MEDLINE, Scopus, CINAHL, and the Clinical Trials Registry. Key terms that were used to identify potentially relevant studies included long-covid, post-covid, sequelae, exercise therapy, rehabilitation, physical activity, physical therapy, and randomized controlled trial.
    Study selection: This study included randomized clinical trials that compared respiratory training and exercise-based rehabilitation interventions with either placebo, usual care, waiting list, or control in patients with PCC.
    Data extraction and synthesis: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. A pairwise bayesian random-effects meta-analysis was performed using vague prior distributions. Risk of bias was assessed using the Cochrane risk of bias tool version 2, and the certainty of evidence was evaluated using the GRADE system by 2 independent researchers.
    Main outcomes and measures: The primary outcome was functional exercise capacity, measured at the closest postintervention time point by the 6-minute walking test. Secondary outcomes were fatigue, lower limb muscle function, dyspnea, respiratory function, and quality of life. All outcomes were defined a priori. Continuous outcomes were reported as standardized mean differences (SMDs) with 95% credible intervals (CrIs) and binary outcomes were summarized as odds ratios with 95% CrIs. The between-trial heterogeneity was quantified using the between-study variance, τ2, and 95% CrIs.
    Results: Of 1834 identified records, 1193 were screened, and 14 trials (1244 patients; 45% female participants; median [IQR] age, 50 [47 to 56] years) were included in the analyses. Rehabilitation interventions were associated with improvements in functional exercise capacity (SMD, -0.56; 95% CrI, -0.87 to -0.22) with moderate certainty in 7 trials (389 participants). These improvements had a 99% posterior probability of superiority when compared with current standard care. The value of τ2 (0.04; 95% CrI, 0.00 to 0.60) indicated low statistical heterogeneity. However, there was significant uncertainty and imprecision regarding the probability of experiencing exercise-induced adverse events (odds ratio, 1.68; 95% CrI, 0.32 to 9.94).
    Conclusions and relevance: The findings of this systematic review and meta-analysis suggest that rehabilitation interventions are associated with improvements in functional exercise capacity, dyspnea, and quality of life, with a high probability of improvement compared with the current standard care; the certainty of evidence was moderate for functional exercise capacity and quality of life and low for other outcomes. Given the uncertainty surrounding the safety outcomes, additional trials with enhanced monitoring of adverse events are necessary.
    MeSH term(s) Humans ; Adult ; Female ; Middle Aged ; Male ; Quality of Life ; Post-Acute COVID-19 Syndrome ; Bayes Theorem ; COVID-19 ; Dyspnea/etiology ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-09-05
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.33838
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  5. Article ; Online: Rehabilitation needs of the first cohort of post-acute COVID-19 patients in Hubei, China.

    Li, Zhengliang / Zheng, Chanjuan / Duan, Can / Zhang, Yangpu / Li, Qinglin / Dou, Zulin / Li, Jianan / Xia, Wenguang

    European journal of physical and rehabilitation medicine

    2020  Volume 56, Issue 3, Page(s) 339–344

    Abstract: ... Through this study, we aim to learn more about the dysfunctions and rehabilitation needs of COVID-19 patients ... for rehabilitation is high among COVID-19 patients, which requires the quick establishment of a comprehensive and ... Rehabilitation that mainly requested by the patients included exercise guidance, dietary instruction ...

    Abstract Background: Corona Virus Disease-2019 (COVID-19) is an acute respiratory infectious disease. Despite being clinically cured, some patients still find it difficult to return to their normal life and work due to the varying degree of dysfunctions that they have, as part of the disease's aftereffect. Through this study, we aim to learn more about the dysfunctions and rehabilitation needs of COVID-19 patients.
    Methods: In this survey, the basic information, dysfunctions, and rehabilitation needs of the hospitalized COVID-19 patients, who were selected by convenience sampling in Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine, were obtained using a self-designed questionnaire. The research was conducted from February 29, 2020 to March 2, 2020.
    Results: A total of 280 patients were finally included, who were mainly over 51 years of age (64.2%). The main physical dysfunctions that the patients had were sleep disorders (63.6%), decreased activity endurance (61.4%), and respiratory dysfunction (57.9%), while the main psychological dysfunctions included anxiety (62.1%) and fear (50.0%). Rehabilitation that mainly requested by the patients included exercise guidance, dietary instruction, traditional Chinese medicine therapy, physical therapy, and Chinese traditional health exercises.
    Conclusions: The demand for rehabilitation is high among COVID-19 patients, which requires the quick establishment of a comprehensive and individualized rehabilitation program, to be fulfilled.
    MeSH term(s) Adult ; Aged ; Betacoronavirus ; COVID-19 ; China ; Cohort Studies ; Coronavirus Infections/complications ; Coronavirus Infections/psychology ; Coronavirus Infections/rehabilitation ; Female ; Health Services Needs and Demand ; Health Status ; Hospitalization ; Humans ; Male ; Middle Aged ; Pandemics ; Patient Acceptance of Health Care ; Pneumonia, Viral/complications ; Pneumonia, Viral/psychology ; Pneumonia, Viral/rehabilitation ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-16
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2426908-6
    ISSN 1973-9095 ; 1973-9087
    ISSN (online) 1973-9095
    ISSN 1973-9087
    DOI 10.23736/S1973-9087.20.06298-X
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