Article ; Online: Parvovirus B19: A Cause of Sepsislike Syndrome in an Infant.
2018 Volume 141, Issue 6
Abstract: ... PB19 should be suspected as a cause of sepsislike syndrome in young infants, especially those who have ... We report a case of sepsislike syndrome caused by PB19 infection in a 56-day-old infant whose mother had ... reports contained descriptions of PB19 infection as a cause of sepsislike syndrome in this age group ...
| Abstract | Parvovirus B19 (PB19) is an important human pathogen that results in a wide spectrum of clinical outcomes, from mild, self-limiting erythema infectiosum in immunocompetent children and arthralgia in adults to lethal cytopenia in immunocompromised patients and intrauterine fetal death. However, there have been few reports of PB19 infection in neonates or young infants (aged 28-90 days), and no previous reports contained descriptions of PB19 infection as a cause of sepsislike syndrome in this age group. We report a case of sepsislike syndrome caused by PB19 infection in a 56-day-old infant whose mother had polyarthralgia at the time of his admission. PB19 infection was diagnosed on the basis of positive polymerase chain reaction results for PB19 DNA in the serum and cerebrospinal fluid. Positive immunoglobulin M and negative immunoglobulin G for PB19 suggested acute infection. He was admitted to the ICU because of poor peripheral circulation, but fully recovered without antibiotic administration. After excluding other possible pathogens, PB19 should be suspected as a cause of sepsislike syndrome in young infants, especially those who have close contact with PB19-infected individuals. |
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| MeSH term(s) | DNA, Viral/blood ; DNA, Viral/cerebrospinal fluid ; Diagnosis, Differential ; Erythema Infectiosum/diagnosis ; Erythema Infectiosum/transmission ; Humans ; Immunocompetence ; Immunoglobulin M/blood ; Infant ; Male ; Parvovirus B19, Human/genetics ; Parvovirus B19, Human/isolation & purification ; Polymerase Chain Reaction ; Systemic Inflammatory Response Syndrome/diagnosis | ||||||||||
| Chemical Substances | DNA, Viral ; Immunoglobulin M | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2018-05-18 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 207677-9 | ||||||||||
| ISSN | 1098-4275 ; 0031-4005 | ||||||||||
| ISSN (online) | 1098-4275 | ||||||||||
| ISSN | 0031-4005 | ||||||||||
| DOI | 10.1542/peds.2017-1435 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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