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  1. Book: Intestinal stem cells

    Ordóñez-Morán, Paloma

    methods and protocols

    (Methods in molecular biology ; 2171 ; Springer protocols)

    2020  

    Author's details edited by Paloma Ordóñez-Morán
    Series title Methods in molecular biology ; 2171
    Springer protocols
    Collection
    Language English
    Size xv, 350 Seiten, Illustrationen
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT020551206
    ISBN 978-1-0716-0746-6 ; 9781071607473 ; 1-0716-0746-4 ; 1071607472
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -2171- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Aging of intestinal stem cells.

    Nalapareddy, Kodandaramireddy / Zheng, Yi / Geiger, Hartmut

    Stem cell reports

    2022  Volume 17, Issue 4, Page(s) 734–740

    Abstract: ... as the underlying mechanisms of aging intestinal stem cells are beginning to unravel. This review summarizes ... our current knowledge on stem cell-intrinsic mechanisms of aging of intestinal stem cells and their connection ... even revert the aging of intestinal stem cells. ...

    Abstract The intestine is one of the organs that relies on stem cell function for maintaining tissue homeostasis. Recent findings on intestinal aging show that intestinal architecture, such as villus length, crypt size, and cell composition changes in the aged crypts. The correspondent decline in the regenerative capacity of the intestine is mainly due to a decline in intestinal stem cell function upon aging, as the underlying mechanisms of aging intestinal stem cells are beginning to unravel. This review summarizes our current knowledge on stem cell-intrinsic mechanisms of aging of intestinal stem cells and their connection to extrinsic factors, such as niche cells and microbiota and will introduce recent approaches to attenuate or even revert the aging of intestinal stem cells.
    MeSH term(s) Homeostasis ; Intestinal Mucosa ; Intestines ; Stem Cells
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2022.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effects of hormones on intestinal stem cells.

    Liu, Li / Zhang, Lilong / Li, Chunlei / Qiu, Zhendong / Kuang, Tianrui / Wu, Zhongkai / Deng, Wenhong

    Stem cell research & therapy

    2023  Volume 14, Issue 1, Page(s) 105

    Abstract: The maintenance of intestinal renewal and repair mainly depends on intestinal stem cells (ISCs ... in the body, have various effects on the growth and replacement of intestinal stem cells. This review ... summarises recent progress in the identification of hormones associated with intestinal stem cells ...

    Abstract The maintenance of intestinal renewal and repair mainly depends on intestinal stem cells (ISCs), which can also contribute to the growth of intestinal tumours. Hormones, which are vital signalling agents in the body, have various effects on the growth and replacement of intestinal stem cells. This review summarises recent progress in the identification of hormones associated with intestinal stem cells. Several hormones, including thyroid hormone, glucagon-like peptide-2, androgens, insulin, leptin, growth hormone, corticotropin-releasing hormone and progastrin, promote the development of intestinal stem cells. However, somatostatin and melatonin are two hormones that prevent the proliferation of intestinal stem cells. Therefore, new therapeutic targets for the diagnosis and treatment of intestinal illnesses can be identified by examining the impact of hormones on intestinal stem cells.
    MeSH term(s) Insulin/pharmacology ; Thyroid Hormones ; Stem Cells ; Intestinal Mucosa
    Chemical Substances Insulin ; Thyroid Hormones
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2548671-8
    ISSN 1757-6512 ; 1757-6512
    ISSN (online) 1757-6512
    ISSN 1757-6512
    DOI 10.1186/s13287-023-03336-1
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  4. Article: AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis

    Jasper, Heinrich

    http://lobid.org/resources/99370674014306441#!, 10(1):2988

    2019  

    Abstract: Precise control of stem cell (SC) proliferation ensures tissue homeostasis. In the Drosophila ... tissue homeostasis by dynamic control of somatic stem cell activity. ... intestine, injury-induced regeneration involves initial activation of intestinal SC (ISC) proliferation and ...

    Institution Leibniz-Institut für Alternsforschung
    Abstract Precise control of stem cell (SC) proliferation ensures tissue homeostasis. In the Drosophila intestine, injury-induced regeneration involves initial activation of intestinal SC (ISC) proliferation and subsequent return to quiescence. These two phases of the regenerative response are controlled by differential availability of the BMP type I receptor Thickveins (Tkv), yet how its expression is dynamically regulated remains unclear. Here we show that during homeostasis, the E3 ubiquitin ligase Highwire and the ubiquitin-proteasome system maintain low Tkv protein expression. After ISC activation, Tkv is stabilized by proteasome inhibition and undergoes endocytosis due to the induction of the nucleoside diphosphate kinase Abnormal Wing Disc (AWD). Tkv internalization is required for the activation of the Smad protein Mad, and for the return to quiescence after a regenerative episode. Our data provide insight into the mechanisms ensuring tissue homeostasis by dynamic control of somatic stem cell activity.
    Keywords Animals ; Animals [MeSH] ; Bone Morphogenetic Proteins/metabolism ; Bone Morphogenetic Proteins/metabolism [MeSH] ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/metabolism [MeSH] ; Drosophila Proteins/metabolism ; Drosophila Proteins/metabolism [MeSH] ; Drosophila melanogaster ; Drosophila melanogaster [MeSH] ; Female ; Female [MeSH] ; Homeostasis/physiology ; Homeostasis/physiology [MeSH] ; Intestines/cytology ; Intestines/cytology [MeSH] ; Models, Animal ; Models, Animal [MeSH] ; Nerve Tissue Proteins/metabolism ; Nerve Tissue Proteins/metabolism [MeSH] ; Nucleoside-Diphosphate Kinase/metabolism ; Nucleoside-Diphosphate Kinase/metabolism [MeSH] ; Signal Transduction/physiology ; Signal Transduction/physiology [MeSH] ; Stem Cells/metabolism ; Stem Cells/metabolism [MeSH] ; Protein-Serine-Threonine Kinases/metabolism ; Protein-Serine-Threonine Kinases/metabolism [MeSH] ; Receptors, Cell Surface/metabolism ; Receptors, Cell Surface/metabolism [MeSH] ; Regeneration ; Regeneration [MeSH] ; Transcription Factors/metabolism ; Transcription Factors/metabolism [MeSH]
    Language English
    Document type Article
    Database Repository for Life Sciences

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  5. Article: Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction

    Leibniz-Institut für Alternsforschung

    http://lobid.org/resources/99370674014306441#!, 10(1):1050

    2019  

    Abstract: ... stem cells (SCs) uniquely maintain their proteostatic capacity through mechanisms that remain incompletely ... understood. Here, we describe and characterize a 'proteostatic checkpoint' in Drosophila intestinal SCs (ISCs ... expression of CncC or Atg8a. This limits age-related intestinal barrier dysfunction and can result ...

    Abstract A decline in protein homeostasis (proteostasis) has been proposed as a hallmark of aging. Somatic stem cells (SCs) uniquely maintain their proteostatic capacity through mechanisms that remain incompletely understood. Here, we describe and characterize a 'proteostatic checkpoint' in Drosophila intestinal SCs (ISCs). Following a breakdown of proteostasis, ISCs coordinate cell cycle arrest with protein aggregate clearance by Atg8-mediated activation of the Nrf2-like transcription factor cap-n-collar C (CncC). CncC induces the cell cycle inhibitor Dacapo and proteolytic genes. The capacity to engage this checkpoint is lost in ISCs from aging flies, and we show that it can be restored by treating flies with an Nrf2 activator, or by over-expression of CncC or Atg8a. This limits age-related intestinal barrier dysfunction and can result in lifespan extension. Our findings identify a new mechanism by which somatic SCs preserve proteostasis, and highlight potential intervention strategies to maintain regenerative homeostasis.
    Keywords Cell Cycle Checkpoints/physiology ; Cell Cycle Checkpoints/physiology [MeSH] ; Animals ; Animals [MeSH] ; Animals, Genetically Modified ; Animals, Genetically Modified [MeSH] ; Aging/physiology ; Aging/physiology [MeSH] ; Drosophila Proteins/metabolism ; Drosophila Proteins/metabolism [MeSH] ; Drosophila melanogaster ; Drosophila melanogaster [MeSH] ; Epithelium/physiology ; Epithelium/physiology [MeSH] ; Epithelial Cells/physiology ; Epithelial Cells/physiology [MeSH] ; Female ; Female [MeSH] ; Intestinal Mucosa/cytology ; Intestinal Mucosa/cytology [MeSH] ; Intestinal Mucosa/physiology ; Intestinal Mucosa/physiology [MeSH] ; Longevity ; Longevity [MeSH] ; Nuclear Proteins/metabolism ; Nuclear Proteins/metabolism [MeSH] ; Stem Cells/physiology ; Stem Cells/physiology [MeSH] ; Proteostasis/physiology ; Proteostasis/physiology [MeSH] ; Repressor Proteins/metabolism ; Repressor Proteins/metabolism [MeSH]
    Language English
    Document type Article
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  6. Article ; Online: Intestinal Stem Cells Require Iron to Orchestrate Tissue Repair Mechanisms.

    Collins, James F

    The Journal of nutrition

    2024  Volume 154, Issue 4, Page(s) 1067–1068

    MeSH term(s) Humans ; Iron ; Intestines ; Intestinal Mucosa ; Inflammatory Bowel Diseases
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Editorial
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.1016/j.tjnut.2024.02.019
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  7. Article: The Potential Role of Intestinal Stem Cells and Microbiota for the Treatment of Colorectal Cancer.

    Arjmand, Babak / Alavi-Moghadam, Sepideh / Faraji, Zahra / Aghajanpoor-Pasha, Morteza / Jalaeikhoo, Hasan / Rajaeinejad, Mohsen / Nikandish, Mohsen / Faridfar, Ali / Rezazadeh-Mafi, Ahmad / Rezaei-Tavirani, Mostafa / Irompour, Arsalan

    Advances in experimental medicine and biology

    2024  

    Abstract: ... survival rates. Recent research highlights the role of gut microbiota and intestinal stem cells in maintaining ... The interaction between gut microbiota and stem cells influences epithelial self-renewal and overall intestinal ... intestinal stem cells in treating colorectal cancer. ...

    Abstract Colorectal cancer is a global health concern with high incidence and mortality rates. Conventional treatments like surgery, chemotherapy, and radiation therapy have limitations in improving patient survival rates. Recent research highlights the role of gut microbiota and intestinal stem cells in maintaining intestinal health and their potential therapeutic applications in colorectal cancer treatment. The interaction between gut microbiota and stem cells influences epithelial self-renewal and overall intestinal homeostasis. Novel therapeutic approaches, including immunotherapy, targeted therapy, regenerative medicine using stem cells, and modulation of gut microbiota, are being explored to improve treatment outcomes. Accordingly, this chapter provides an overview of the potential therapeutic applications of gut microbiota and intestinal stem cells in treating colorectal cancer.
    Language English
    Publishing date 2024-05-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/5584_2024_803
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  8. Article ; Online: The epigenetic landscape in intestinal stem cells and its deregulation in colorectal cancer.

    Larue, Axelle / Atlasi, Yaser

    Stem cells (Dayton, Ohio)

    2024  

    Abstract: ... mechanisms modulate chromatin functions in intestinal stem cells (ISCs) is currently an active area ... in the regulation of stem cell self-renewal and differentiation, both in embryonic development and within adult ... tissues. A prime example of this finely tuned epigenetic control is observed in the gastrointestinal ...

    Abstract Epigenetic mechanisms play a pivotal role in controlling gene expression and cellular plasticity in both normal physiology and pathophysiological conditions. These mechanisms are particularly important in the regulation of stem cell self-renewal and differentiation, both in embryonic development and within adult tissues. A prime example of this finely tuned epigenetic control is observed in the gastrointestinal lining, where the small intestine undergoes renewal approximately every 3-5 days. How various epigenetic mechanisms modulate chromatin functions in intestinal stem cells (ISCs) is currently an active area of research. In this review, we discuss the main epigenetic mechanisms that control ISC differentiation under normal homeostasis. Furthermore, we explore the dysregulation of these mechanisms in the context of colorectal cancer (CRC) development. By outlining the main epigenetic mechanisms contributing to CRC, we highlight the recent therapeutics development and future directions for colorectal cancer research.
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1143556-2
    ISSN 1549-4918 ; 1066-5099
    ISSN (online) 1549-4918
    ISSN 1066-5099
    DOI 10.1093/stmcls/sxae027
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  9. Article ; Online: Bioelectric regulation of intestinal stem cells.

    Petsakou, Afroditi / Perrimon, Norbert

    Trends in cell biology

    2022  Volume 33, Issue 7, Page(s) 555–567

    Abstract: Proper regulation of ion balance across the intestinal epithelium is essential ... for physiological functions, while ion imbalance causes intestinal disorders with dire health consequences. Ion channels ...

    Abstract Proper regulation of ion balance across the intestinal epithelium is essential for physiological functions, while ion imbalance causes intestinal disorders with dire health consequences. Ion channels, pumps, and exchangers are vital for regulating ion movements (i.e., bioelectric currents) that control epithelial absorption and secretion. Recent in vivo studies used the Drosophila gut to identify conserved pathways that link regulators of Ca
    MeSH term(s) Animals ; Drosophila/metabolism ; Stem Cells/metabolism ; Intestinal Mucosa/metabolism ; Drosophila Proteins/metabolism ; Ion Channels/metabolism ; Cell Proliferation ; Intestines
    Chemical Substances Drosophila Proteins ; Ion Channels
    Language English
    Publishing date 2022-11-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2022.10.003
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  10. Article ; Online: Vasoactive intestinal peptide exerts an osteoinductive effect in human mesenchymal stem cells.

    Castro-Vázquez, David / Arribas-Castaño, Paula / García-López, Iván / Gutiérrez-Cañas, Irene / Pérez-García, Selene / Lamana, Amalia / Villanueva-Romero, Raúl / Cabrera-Martín, Alicia / Tecza, Karolina / Martínez, Carmen / Juarranz, Yasmina / Gomariz, Rosa P / Carrión, Mar

    BioFactors (Oxford, England)

    2024  

    Abstract: ... vasoactive intestinal peptide (VIP) on the differentiation process of human mesenchymal stem cells (MSCs) into osteoblasts and ... Several neuropeptides present in bone tissues, produced by nerve fibers and bone cells, have been ... as they differentiate into osteoblasts, suggesting the presence of an autocrine signaling pathway in these cells ...

    Abstract Several neuropeptides present in bone tissues, produced by nerve fibers and bone cells, have been reported to play a role in regulating the fine-tuning of osteoblast and osteoclast functions to maintain bone homeostasis. This study aims to characterize the influence of the neuropeptide vasoactive intestinal peptide (VIP) on the differentiation process of human mesenchymal stem cells (MSCs) into osteoblasts and on their anabolic function. We describe the mRNA and protein expression profile of VIP and its receptors in MSCs as they differentiate into osteoblasts, suggesting the presence of an autocrine signaling pathway in these cells. Our findings reveal that VIP enhances the expression of early osteoblast markers in MSCs under osteogenic differentiation and favors both bone matrix formation and proper cytoskeletal reorganization. Finally, our data suggest that VIP could be exerting a direct modulatory role on the osteoblast to osteoclast signaling by downregulating the receptor activator of nuclear factor-κB ligand/osteoprotegerin ratio. These results highlight the potential of VIP as an osteoinductive differentiation factor, emerging as a key molecule in the maintenance of human bone homeostasis.
    Language English
    Publishing date 2024-05-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 59230-4
    ISSN 1872-8081 ; 0951-6433
    ISSN (online) 1872-8081
    ISSN 0951-6433
    DOI 10.1002/biof.2062
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