Artikel ; Online: Mental disorders and risk of COVID-19-related mortality, hospitalisation, and intensive care unit admission: a systematic review and meta-analysis.
The lancet. Psychiatry
2021 Band 8, Heft 9, Seite(n) 797–812
Abstract: ... the specific risks of COVID-19-related mortality, hospitalisation, and intensive care unit (ICU) admission ... The presence of any mental disorder was associated with an increased risk of COVID-19 mortality (OR 2·00 [95 ... mood disorders, and exposure to antipsychotics and anxiolytics were associated with COVID-19 mortality ...
| Abstract | Background: Mental disorders might be a risk factor for severe COVID-19. We aimed to assess the specific risks of COVID-19-related mortality, hospitalisation, and intensive care unit (ICU) admission associated with any pre-existing mental disorder, and specific diagnostic categories of mental disorders, and exposure to psychopharmacological drug classes. Methods: In this systematic review and meta-analysis, we searched Web of Science, Cochrane, PubMed, and PsycINFO databases between Jan 1, 2020, and March 5, 2021, for original studies reporting data on COVID-19 outcomes in patients with psychiatric disorders compared with controls. We excluded studies with overlapping samples, studies that were not peer-reviewed, and studies written in languages other than English, Danish, Dutch, French, German, Italian, and Portuguese. We modelled random-effects meta-analyses to estimate crude odds ratios (OR) for mortality after SARS-CoV-2 infection as the primary outcome, and hospitalisation and ICU admission as secondary outcomes. We calculated adjusted ORs for available data. Heterogeneity was assessed using the I Findings: 841 studies were identified by the systematic search, of which 33 studies were included in the systematic review and 23 studies in the meta-analysis, comprising 1 469 731 patients with COVID-19, of whom 43 938 had mental disorders. The sample included 130 807 females (8·9% of the whole sample) and 130 373 males (8·8%). Nine studies provided data on patient race and ethnicity, and 22 studies were rated as high quality. The presence of any mental disorder was associated with an increased risk of COVID-19 mortality (OR 2·00 [95% CI 1·58-2·54]; I Interpretation: Pre-existing mental disorders, in particular psychotic and mood disorders, and exposure to antipsychotics and anxiolytics were associated with COVID-19 mortality in both crude and adjusted models. Although further research is required to determine the underlying mechanisms, our findings highlight the need for targeted approaches to manage and prevent COVID-19 in at-risk patient groups identified in this study. Funding: None. Translations: For the Italian, French and Portuguese translations of the abstract see Supplementary Materials section. |
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| Mesh-Begriff(e) | COVID-19/complications ; COVID-19/mortality ; Hospitalization/statistics & numerical data ; Humans ; Intensive Care Units/statistics & numerical data ; Mental Disorders/complications ; Mental Disorders/epidemiology ; Risk Factors |
| Sprache | Englisch |
| Erscheinungsdatum | 2021-07-17 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article ; Meta-Analysis ; Systematic Review |
| ISSN | 2215-0374 |
| ISSN (online) | 2215-0374 |
| DOI | 10.1016/S2215-0366(21)00232-7 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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