Article ; Online: SARS-CoV-2 seroprevalence trends in healthy blood donors during the COVID-19 outbreak in Milan.
Blood transfusion = Trasfusione del sangue
2021 Volume 19, Issue 3, Page(s) 181–189
Abstract: ... by the SARS-CoV-2 outbreak. The aim of this study was to examine the seroprevalence trends of SARS-CoV-2 ... At the start of the outbreak, the overall adjusted seroprevalence of SARS-CoV-2 was 2.7% (95% CI: 0.3-6%; p<0 ... CI: 2.8-8.2; p=0.004 for trend), but there was no increase in IgM: Discussion: SARS-CoV-2 ...
| Abstract | Background: The Milan metropolitan area in Northern Italy was among the most severely hit by the SARS-CoV-2 outbreak. The aim of this study was to examine the seroprevalence trends of SARS-CoV-2 in healthy asymptomatic adults, and the risk factors and laboratory correlates of positive tests. Materials and methods: We conducted a cross-sectional study in a random sample of blood donors, who were asymptomatic at the time of evaluation, at the beginning of the first phase (February 24 Results: The test had a 100/98.3 sensitivity/specificity (n=32/120 positive/negative controls, respectively), and the IgG test was validated in a subset by an independent ELISA against the Spike protein (n=34, p<0.001). At the start of the outbreak, the overall adjusted seroprevalence of SARS-CoV-2 was 2.7% (95% CI: 0.3-6%; p<0.0001 vs 120 historical controls). During the study period, characterised by a gradual implementation of social distancing measures, there was a progressive increase in the adjusted seroprevalence to 5.2% (95% CI: 2.4-9.0; 4.5%, 95% CI: 0.9-9.2% according to a Bayesian estimate) due to a rise in IgG reactivity to 5% (95% CI: 2.8-8.2; p=0.004 for trend), but there was no increase in IgM Discussion: SARS-CoV-2 infection was already circulating in Milan at the start of the outbreak. The pattern of IgM/IgG reactivity was influenced by age: IgM was more frequently detected in participants aged >45 years. By the end of April, 2.4-9.0% of healthy adults had evidence of seroconversion. |
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| MeSH term(s) | Adult ; Age Factors ; Antibodies, Viral/blood ; Asymptomatic Infections/epidemiology ; Bayes Theorem ; Blood Donors/statistics & numerical data ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19 Serological Testing/methods ; Confidence Intervals ; Cross-Sectional Studies ; Female ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Italy/epidemiology ; Male ; Middle Aged ; Pandemics ; Regression Analysis ; Risk Factors ; SARS-CoV-2/immunology ; Seroconversion ; Seroepidemiologic Studies ; Spike Glycoprotein, Coronavirus/immunology |
| Chemical Substances | Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M ; Spike Glycoprotein, Coronavirus ; spike glycoprotein, SARS-CoV |
| Language | English |
| Publishing date | 2021-02-03 |
| Publishing country | Italy |
| Document type | Journal Article |
| ZDB-ID | 2135732-8 |
| ISSN | 2385-2070 ; 0041-1787 ; 1723-2007 |
| ISSN (online) | 2385-2070 |
| ISSN | 0041-1787 ; 1723-2007 |
| DOI | 10.2450/2021.0324-20 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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