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  1. Article ; Online: Eosinophils and Chronic Respiratory Diseases in Hospitalized COVID-19 Patients.

    Valverde-Monge, Marcela / Cañas, José A / Barroso, Blanca / Betancor, Diana / Ortega-Martin, Laura / Gómez-López, Alicia / Rodríguez-Nieto, María Jesús / Mahíllo-Fernández, Ignacio / Sastre, Joaquín / Del Pozo, Victoria

    Frontiers in immunology

    2021  Volume 12, Page(s) 668074

    Abstract: ... In patients with chronic respiratory diseases who develop COVID-19, age seems to be the main risk factor ... between eosinophils and COVID-19, with a focus on disease severity and patients with underlying ... Background: Studies on the role of eosinophils in coronavirus disease 2019 (COVID-19) are scarce ...

    Abstract Background: Studies on the role of eosinophils in coronavirus disease 2019 (COVID-19) are scarce, though available findings suggest a possible association with disease severity. Our study analyzes the relationship between eosinophils and COVID-19, with a focus on disease severity and patients with underlying chronic respiratory diseases.
    Methods: We performed a retrospective analysis of 3018 subjects attended at two public hospitals in Madrid (Spain) with PCR-confirmed SARS-CoV-2 infection from January 31 to April 17, 2020. Patients with eosinophil counts less than 0.02×10
    Results: Of the 3018 patients enrolled, 479 were excluded because of lack of information at the time of admission. Of 2539 subjects assessed, 1396 patients presented an eosinophil count performed on admission, revealing eosinopenia in 376 cases (26.93%). Eosinopenia on admission was associated with a higher risk of intensive care unit (ICU) or respiratory intensive care unit (RICU) admission (OR:2.21; 95%CI:1.42-3.45;
    Conclusions: Eosinopenia on admission conferred a higher risk of severe disease (requiring ICU/RICU care), but was not associated with increased mortality. In patients with chronic respiratory diseases who develop COVID-19, age seems to be the main risk factor for progression to severe disease or death.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; COVID-19/blood ; COVID-19/immunology ; Chronic Disease ; Eosinophils/immunology ; Female ; Hospitalization ; Humans ; Leukocyte Count ; Lung Diseases/epidemiology ; Male ; Middle Aged ; Prevalence ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Spain
    Language English
    Publishing date 2021-06-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.668074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The impact of COVID-19 on Japanese patients with eosinophilic gastrointestinal disorders during the vaccination era.

    Fujiwara, Yasuhiro / Sawada, Akinari / Higashimori, Akira / Nakata, Rieko / Tanoue, Kojiro / Nishida, Yu / Maruyama, Hirotsugu / Ominami, Masaki / Fukunaga, Shusei / Otani, Koji / Hosomi, Shuhei / Kamata, Noriko / Tanaka, Fumio / Nagami, Yasuaki / Taira, Koichi

    JGH open : an open access journal of gastroenterology and hepatology

    2023  Volume 7, Issue 10, Page(s) 702–707

    Abstract: ... with EoE and 46 with non-EoE EGIDs) included in this study, 31 (28%) patients reported having COVID-19 ... vaccinations, and 11 (16%) patients received no vaccinations. COVID-19 was mild in all but one patient who had ... determined. Patients who reported having COVID-19 also reported their hospitalization history ...

    Abstract Background: Eosinophilic gastrointestinal disorders (EGIDs) are chronic allergic diseases categorized as eosinophilic esophagitis (EoE) and non-EoE EGIDs. Few studies regarding the association between EGIDs and coronavirus disease 2019 (COVID-19) have been reported. Although most Japanese individuals received the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine, the incidence of COVID-19 remained high in 2022. This study examines the incidence of COVID-19 in patients with EGIDs during the vaccination era.
    Methods: Patients with EGIDs who visited our department between October and December 2022 were enrolled in the study. The incidence and severity of COVID-19 prior to October 1, 2022 were determined. Patients who reported having COVID-19 also reported their hospitalization history, intensive care unit admissions, and EGID flares. The number of SARS-CoV-2 vaccinations received and treatment for EGIDs were obtained from the patients' medical records.
    Results: Of 111 patients with EGIDs (65 with EoE and 46 with non-EoE EGIDs) included in this study, 31 (28%) patients reported having COVID-19, including 14 (22%) with EoE and 17 (37%) with non-EoE EGIDs. Fifty-nine (84%) patients received two or more vaccinations, and 11 (16%) patients received no vaccinations. COVID-19 was mild in all but one patient who had moderate symptoms. COVID-19 was not associated with EGID flares. EGID treatments and an unvaccinated status were not associated with an increased risk of COVID-19.
    Conclusion: COVID-19 was mild in patients with EGIDs and not associated with EGIDs flares during the vaccination era. There was a relatively high incidence of COVID-19 among patients with non-EoE EGIDs.
    Language English
    Publishing date 2023-09-21
    Publishing country Australia
    Document type Journal Article
    ISSN 2397-9070
    ISSN (online) 2397-9070
    DOI 10.1002/jgh3.12969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Relationship between blood eosinophil levels and COVID-19 mortality.

    Yan, Bingdi / Yang, Junling / Xie, Yan / Tang, Xiaolei

    The World Allergy Organization journal

    2021  Volume 14, Issue 3, Page(s) 100521

    Abstract: ... worsening, indicates that COVID-19 patients may progress to critical disease and have a significantly higher ... among COVID-19 patients was a decline of eosinophil levels (eosinopenia). However, results from previous ... coronary heart disease, diabetes, and chronic lung disease, a progressive decline of eosinophil levels was independently ...

    Abstract Objectives: A novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is causing the worldwide coronavirus disease 2019 (COVID-19) outbreak with high mortality. A unique finding among COVID-19 patients was a decline of eosinophil levels (eosinopenia). However, results from previous studies on the relationship between eosinopenia and disease severity were inconsistent. The objective of this study is to determine the relationship between eosinopenia and COVID-19 mortality as well as the clinical conditions that could potentially lead to mortality.
    Methods: One hundred ninety patients diagnosed as moderate, severe, or critical COVID-19 at hospital admission were enrolled. Data collected from patients' medical records on the second day after hospital admission included medical histories, clinical symptoms, chest images of computed tomography (CT), laboratory examinations, and outcomes.
    Results: Eosinophil levels were significantly lower in patients with critical disease, when compared to those with moderate and severe diseases. After controlled for confounding factors, ie, age, gender, hypertension, coronary heart disease, diabetes, and chronic lung disease, a progressive decline of eosinophil levels was independently associated with mortality. Moreover, eosinophil levels significantly and positively correlated with platelet and D-dimer levels but significantly and inversely correlated with serum levels of urea, creatinine, aspartate aminotransferase, lactate dehydrogenase, and creatine kinase.
    Conclusions: Eosinopenia, if progressively worsening, indicates that COVID-19 patients may progress to critical disease and have a significantly higher chance of mortality. Additionally, eosinopenia correlates with biomarkers of coagulation disorder and those of tissue damage in kidney, liver, and other tissues.
    Language English
    Publishing date 2021-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2581968-9
    ISSN 1939-4551
    ISSN 1939-4551
    DOI 10.1016/j.waojou.2021.100521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients : A single center registry-based retrospective cohort study.

    Salai, Grgur / Vrazic, Hrvoje / Kovacevic, Ivona / Janes, Linda Malnar / Marasovic, Ivan / Ranilovic, Darjan / Vukoja, Damir / Zelenika Margeta, Marina / Huljev-Sipos, Ivana / Lalic, Kristina / Spoljaric, Marko / Tekavec-Trkanjec, Jasna / Vergles, Mirna / Lucijanic, Marko / Luksic, Ivica / Ljubicic, Divo

    Wiener klinische Wochenschrift

    2023  Volume 135, Issue 9-10, Page(s) 235–243

    Abstract: ... of peripheral blood eosinophil count on all-cause mortality of patients hospitalized with SARS-CoV‑2 infection ... Introduction: The impact of asthma and chronic obstructive pulmonary disease (COPD) in the setting ... of severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) infection is not clearly defined. Blood eosinophil count is a standard ...

    Abstract Introduction: The impact of asthma and chronic obstructive pulmonary disease (COPD) in the setting of severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) infection is not clearly defined. Blood eosinophil count is a standard diagnostic test which, according to the previously published literature, might have a potential prognostic role on mortality in patients with SARS-CoV‑2 infection.
    Aim: To investigate the potential prognostic value of peripheral blood eosinophil count on all-cause mortality of patients hospitalized with SARS-CoV‑2 infection, as well as to assess the impact of asthma or COPD premorbidity on all-cause mortality.
    Material and methods: We conducted a retrospective registry-based cohort study. Survival analysis was performed by employing the Cox proportional hazards regression model at 30 days of follow-up. Prognostic value of eosinophil count on all-cause mortality was assessed using receiver-operating characteristic (ROC) curve analysis.
    Results: A total of 5653 participants were included in the study. Our model did not reveal that pre-existing asthma or COPD is a statistically significant covariate for all-cause mortality but, indicated that higher eosinophil count at admission might have a protective effect (hazard ratio, HR 0.13 (95% confidence interval, CI 0.06-0.27), p = 0.0001). ROC curve analysis indicates cut-off value of 20 cells/mm
    Conclusion: Our results indicate that eosinophil count at hospital admission might have a potential prognostic role for all-cause mortality at 30 days of follow-up; however this was not demonstrated for pre-existing obstructive lung diseases.
    MeSH term(s) Humans ; Eosinophils ; SARS-CoV-2 ; Retrospective Studies ; Cohort Studies ; COVID-19 ; Leukocyte Count ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Asthma/diagnosis
    Language English
    Publishing date 2023-04-24
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-023-02180-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 902: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Eosinophilia Is Associated with Improved COVID-19 Outcomes in Inhaled Corticosteroid-Treated Patients.

    Zein, Joe G / Strauss, Ronald / Attaway, Amy H / Hu, Bo / Milinovich, Alex / Jawhari, Nesreen / Chamat, Soulaima S / Ortega, Victor E

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 3, Page(s) 742–750.e14

    Abstract: ... propensity weighting and adjustment.: Results: Of the 46,397 patients included in the final analyses, 19 ... among preexisting blood absolute eosinophil counts, ICS, and COVID-19-related outcomes.: Methods ... the role of ICS and its interaction with eosinophilia in COVID-19 therapy. ...

    Abstract Background: In addition to their proinflammatory effect, eosinophils have antiviral properties. Similarly, inhaled corticosteroids (ICS) were found to suppress coronavirus replication in vitro and were associated with improved outcomes in coronavirus disease 2019 (COVID-19). However, the interplay between the two and its effect on COVID-19 needs further evaluation.
    Objective: To determine the associations among preexisting blood absolute eosinophil counts, ICS, and COVID-19-related outcomes.
    Methods: We analyzed data from the Cleveland Clinic COVID-19 Research Registry (April 1, 2020 to March 31, 2021). Of the 82,096 individuals who tested positive, 46,397 had blood differential cell counts obtained before severe acute respiratory syndrome coronavirus 2 testing dates. Our end points included the need for hospitalization, admission to the intensive care unit (ICU), and in-hospital mortality. The effect of eosinophilia on outcomes was estimated after propensity weighting and adjustment.
    Results: Of the 46,397 patients included in the final analyses, 19,506 had preexisting eosinophilia (>0.15 × 10
    Conclusions: The association between eosinophilia and improved COVID-19 outcomes depends on ICS. Future randomized controlled trials are needed to determine the role of ICS and its interaction with eosinophilia in COVID-19 therapy.
    MeSH term(s) Adrenal Cortex Hormones ; COVID-19 ; COVID-19 Testing ; Eosinophilia/chemically induced ; Eosinophilia/drug therapy ; Eosinophilia/epidemiology ; Humans ; Pulmonary Disease, Chronic Obstructive/complications ; SARS-CoV-2
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.12.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7086: Show issues Location:
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