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Article ; Online: Even if it looks like COVID-19, think again: the importance of differential diagnosis during a pandemic.

Van Cauwelaert, Stefan / Stylemans, Dimitri / D'Haenens, Alexander / Slabbynck, Hans / Nieuwendijk, Rogier

Acta clinica Belgica

2021  Volume 77, Issue 2, Page(s) 416–420

Abstract: ... of this clinical case is to highlight the importance of considering less prevalent causes of ARDS amid the COVID-19 ... history who demonstrated typical signs of COVID-19 at the start of the pandemic. Based ... on the disease course as well as CT-scan findings, a diagnosis of COVID-19 was made. She progressed to ARDS ...

Abstract Introduction: Antisynthetase syndrome (ASSD) is a rare auto-immune condition that can present as interstitial lung disease (ILD) and progress into Acute Respiratory Distress Syndrome (ARDS).
Importance: The purpose of this clinical case is to highlight the importance of considering less prevalent causes of ARDS amid the COVID-19 pandemic.
Case report: We present a 56-year-old Belgian female of African descent without past medical history who demonstrated typical signs of COVID-19 at the start of the pandemic. Based on the disease course as well as CT-scan findings, a diagnosis of COVID-19 was made. She progressed to ARDS for which she got intubated and was started on venovenous membrane oxygenation (VV-ECMO). Despite initial negative screening for antinuclear antibodies, further analysis revealed anti-Jo-antibodies. Diagnosis of ASSD was eventually retained and immunosuppressive therapy was started. However, pulmonary fibrosis had evolved too far and therapy was halted shortly after.
MeSH term(s) COVID-19 ; Diagnosis, Differential ; Extracorporeal Membrane Oxygenation ; Female ; Humans ; Middle Aged ; Pandemics ; SARS-CoV-2
Language English
Publishing date 2021-01-15
Publishing country England
Document type Case Reports ; Journal Article
ZDB-ID 390201-8
ISSN 2295-3337 ; 0001-5512 ; 1784-3286
ISSN (online) 2295-3337
ISSN 0001-5512 ; 1784-3286
DOI 10.1080/17843286.2021.1872312
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