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Article ; Online: Ferritin levels and COVID-19.

Vargas-Vargas, Manuel / Cortés-Rojo, Christian

Revista panamericana de salud publica = Pan American journal of public health

2020 Volume 44, Page(s) e72

Keywords	covid19
Language	English
Publishing date	2020-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1376934-0
ISSN	1680-5348 ; 1020-4989
ISSN (online)	1680-5348
ISSN	1020-4989
DOI	10.26633/RPSP.2020.72
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Article ; Online: Obesity-Associated Hepatic Steatosis, Somatotropic Axis Impairment, and Ferritin Levels Are Strong Predictors of COVID-19 Severity.

Masi, Davide / Gangitano, Elena / Criniti, Anna / Ballesio, Laura / Anzuini, Antonella / Marino, Luca / Gnessi, Lucio / Angeloni, Antonio / Gandini, Orietta / Lubrano, Carla

Viruses

2023 Volume 15, Issue 2

Abstract: ... liver steatosis indices, liver CT attenuation, ferritin, and IGF-1 serum levels were assessed and correlated ... ferritin levels, but lower liver density, albumin, GH, and IGF-1. ROC analysis confirmed the prognostic ... variability of COVID-19. We performed a retrospective study including SARS-CoV-2-infected patients ...

Abstract	The full spectrum of SARS-CoV-2-infected patients has not yet been defined. This study aimed to evaluate which parameters derived from CT, inflammatory, and hormonal markers could explain the clinical variability of COVID-19. We performed a retrospective study including SARS-CoV-2-infected patients hospitalized from March 2020 to May 2021 at the Umberto I Polyclinic of Rome. Patients were divided into four groups according to the degree of respiratory failure. Routine laboratory examinations, BMI, liver steatosis indices, liver CT attenuation, ferritin, and IGF-1 serum levels were assessed and correlated with severity. Analysis of variance between groups showed that patients with worse prognoses had higher BMI and ferritin levels, but lower liver density, albumin, GH, and IGF-1. ROC analysis confirmed the prognostic accuracy of IGF-1 in discriminating between patients who experienced death/severe respiratory failure and those who did not (AUC 0.688, CI: 0.587 to 0.789,
MeSH term(s)	Humans ; COVID-19/diagnosis ; Insulin-Like Growth Factor I ; SARS-CoV-2 ; Retrospective Studies ; Fatty Liver/diagnosis ; Ferritins ; Obesity/complications
Chemical Substances	Insulin-Like Growth Factor I (67763-96-6) ; Ferritins (9007-73-2)
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15020488
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Ferritin levels and COVID-19

Vargas-Vargas, Manuel / Cortés-Rojo, Christian

Rev. panam. salud pública

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #604052
Database	COVID19

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Article ; Online: Ferritin levels and COVID-19

Manuel Vargas-Vargas / Christian Cortés-Rojo

Revista Panamericana de Salud Pública, Vol 44, Iss 72, Pp 1-

2020 Volume 2

Keywords	Medicine ; R ; Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270 ; covid19
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Pan American Health Organization
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association between serum ferritin level and decreased diffusion capacity 3 months after the onset of COVID-19 pneumonia.

Shinfuku, Kyota / Takasaka, Naoki / Fukuda, Taiki / Chida, Kentaro / Suzuki, Yudai / Shibata, Shun / Kojima, Ayako / Hasegawa, Tsukasa / Yamada, Masami / Yamanaka, Yumie / Hosaka, Yusuke / Seki, Aya / Seki, Yoshitaka / Takeda, Hiroshi / Ishikawa, Takeo / Kuwano, Kazuyoshi

PloS one

2023 Volume 18, Issue 2, Page(s) e0281249

Abstract: Background: Coronavirus disease 2019 (COVID-19) pneumonia can have prolonged sequelae and lead ... parameters and abnormal chest shadows on computed tomography, of COVID-19 pneumonia associated with DLCO ... impairment, and ferritin level was a significantly associated clinical factor. Serum ferritin level could be ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) pneumonia can have prolonged sequelae and lead to respiratory dysfunction, mainly because of impaired diffusion capacity for carbon monoxide (DLCO). The clinical factors associated with DLCO impairment, including blood biochemistry test parameters, remain unclear. Methods: Patients with COVID-19 pneumonia who underwent inpatient treatment between April 2020 and August 2021 were included in this study. A pulmonary function test was performed 3 months after onset, and the sequelae symptoms were investigated. Clinical factors, including blood test parameters and abnormal chest shadows on computed tomography, of COVID-19 pneumonia associated with DLCO impairment were investigated. Results: In total, 54 recovered patients participated in this study. Twenty-six patients (48%) and 12 patients (22%) had sequelae symptoms 2 and 3 months after, respectively. The main sequelae symptoms at 3 months were dyspnea and general malaise. Pulmonary function tests showed that 13 patients (24%) had both DLCO <80% predicted value (pred) and DLCO/alveolar volume (VA) <80% pred, and appeared to have DLCO impairment not attributable to an abnormal lung volume. Clinical factors associated with impaired DLCO were investigated in multivariable regression analysis. Ferritin level of >686.5 ng/mL (odds ratio: 11.08, 95% confidence interval [CI]: 1.84-66.59; p = 0.009) was most strongly associated with DLCO impairment. Conclusions: Decreased DLCO was the most common respiratory function impairment, and ferritin level was a significantly associated clinical factor. Serum ferritin level could be used as a predictor of DLCO impairment in cases of COVID-19 pneumonia.
MeSH term(s)	Humans ; COVID-19/complications ; Respiratory Function Tests/methods ; Respiration ; Ferritins ; Lung/diagnostic imaging ; Pulmonary Diffusing Capacity
Chemical Substances	Ferritins (9007-73-2)
Language	English
Publishing date	2023-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0281249
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Estimation of Serum Ferritin in Mucormycosis Patients and Prognostication Based on the Ferritin Value.

Anand C, Babu / Senthilkumar, Sivasubramaniyam / P, Nivedha / Ibrahim C, Mohammed / Afroze M, Khizer Hussain / M, Ramanathan

Cureus

2022 Volume 14, Issue 4, Page(s) e24013

Abstract: ... died. The post-COVID patients (554.13 ± 371.60) have greater serum ferritin levels than non-COVID ... to have higher serum ferritin values, especially among non-survivors and sick patients than survivors ... Introduction: Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome ...

Abstract	Introduction: Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been implicated in a variety of vulnerable bacterial and fungal diseases. Mucormycosis is a life-threatening infection caused by fungi belonging to the class Zygomycetes and the order Mucorales. The aim of the present study is to evaluate the level of serum ferritin level in mucormycosis patients and to prognosticate them based on those values. Materials and methods: This prospective observational study was conducted in the Department of General Medicine, Mahatma Gandhi Memorial Government Hospital, Tiruchirappalli, in 50 diagnosed mucormycosis patients. Results: During the study period, 44 had prior COVID-19 illness (post-COVID). Six patients had mucormycosis with no prior COVID-19 illness. Rhino-orbital involvement was found in 44 of the 50 cases, with three of them having cerebral extension. Forty-one cases recovered and were discharged, six cases remained sick and were hospitalized, and three died. The post-COVID patients (554.13 ± 371.60) have greater serum ferritin levels than non-COVID patients (259.95 ± 110.15), which are statistically significant. Conclusion: Mucormycosis patients tend to have higher serum ferritin values, especially among non-survivors and sick patients than survivors. For a better chance of recovery and survival, early identification, surgical debridement, and antifungal medications are essential.
Language	English
Publishing date	2022-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.24013
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Article ; Online: Hepcidin and ferritin levels as markers of immune cell activation during septic shock, severe COVID-19 and sterile inflammation.

Frontiers in immunology

2023 Volume 14, Page(s) 1110540

Abstract: ... regulation in various clinical settings and to determine the suitability of hepcidin and/or ferritin levels ... patients with COVID-19, 29 patients in septic shock and eight orthopedic patients who were compared to nine ... inflammation - in septic shock more than four-fold and in COVID-19 six-fold in comparison to sterile ...

Abstract	Introduction: Major clinically relevant inflammatory events such as septic shock and severe COVID-19 trigger dynamic changes in the host immune system, presenting promising candidates for new biomarkers to improve precision diagnostics and patient stratification. Hepcidin, a master regulator of iron metabolism, has been intensively studied in many pathologies associated with immune system activation, however these data have never been compared to other clinical settings. Thus, we aimed to reveal the dynamics of iron regulation in various clinical settings and to determine the suitability of hepcidin and/or ferritin levels as biomarkers of inflammatory disease severity. Cohorts: To investigate the overall predictive ability of hepcidin and ferritin, we enrolled the patients suffering with three different diagnoses - in detail 40 patients with COVID-19, 29 patients in septic shock and eight orthopedic patients who were compared to nine healthy donors and all cohorts to each other. Results: We showed that increased hepcidin levels reflect overall immune cell activation driven by intrinsic stimuli, without requiring direct involvement of infection vectors. Contrary to hepcidin, ferritin levels were more strongly boosted by pathogen-induced inflammation - in septic shock more than four-fold and in COVID-19 six-fold in comparison to sterile inflammation. We also defined the predictive capacity of hepcidin-to-ferritin ratio with AUC=0.79 and Discussion: Our findings confirm that hepcidin is a potent marker of septic shock and other acute inflammation-associated pathologies and demonstrate the utility of the hepcidin-to-ferritin ratio as a predictor of mortality in septic shock, but not in COVID-19.
MeSH term(s)	Humans ; Shock, Septic ; Hepcidins/metabolism ; COVID-19 ; Iron/metabolism ; Ferritins ; Inflammation ; Biomarkers
Chemical Substances	Hepcidins ; Iron (E1UOL152H7) ; Ferritins (9007-73-2) ; Biomarkers
Language	English
Publishing date	2023-01-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1110540
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Article: Comparing serum ferritin levels during COVID-19 infection and recovery period in pediatric patients with transfusion-dependent thalassemia, a single-center study.

Marhaeni, Wulandewi / Felicia, Fabiola Vania / Sumadi Jap, Arvin Leonard / Hartoyo, Edi / Andayani, Pudji

Frontiers in medicine

2023 Volume 10, Page(s) 1056599

Abstract: ... infection.: Objective: To evaluate ferritin levels in TDT with COVID-19 before, during, and after ... The average serum ferritin level during COVID-19 infection was 2373.2 ng/mL higher than before infection and ... COVID-19) patients. Studies have shown higher levels of ferritin in patients with COVID-19 ...

Abstract	Background: Ferritin has been recognized as a predictor of severity among Coronavirus-19 disease (COVID-19) patients. Studies have shown higher levels of ferritin in patients with COVID-19 than in healthy children. Patients with transfusion-dependent thalassemia (TDT) basically have high ferritin level due to iron overload. It is uncertain whether serum ferritin level in these patients is associated with COVID-19 infection. Objective: To evaluate ferritin levels in TDT with COVID-19 before, during, and after the course of infection. Methods: This retrospective study enrolled all TDT children with COVID-19 infection that were hospitalized in Ulin General Hospital Banjarmasin during the COVID-19 pandemic (March 2020 to June 2022). Data were collected from medical records. Results: There were 14 patients included in this study, 5 patients had mild symptoms and 9 patients were asymptomatic. The mean of hemoglobin level upon admission was 8.1 ± 3 g/dL and serum ferritin level were 5148.5 ± 2651.8 ng/mL. The average serum ferritin level during COVID-19 infection was 2373.2 ng/mL higher than before infection and then decreased by 952.4 ng/mL after infection. We found no association of increasing serum ferritin with patients' symptoms ( Conclusion: Serum ferritin levels in TDT children may not reflect disease severity or predict poor outcomes during COVID-19 infection. However, the presence of other co-morbid conditions/confounders warrants cautious interpretation.
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1056599
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effect of ferritin, INR, and D-dimer immunological parameters levels as predictors of COVID-19 mortality: A strong prediction with the decision trees.

Huyut, Mehmet Tahir / Huyut, Zübeyir

Heliyon

2023 Volume 9, Issue 3, Page(s) e14015

Abstract: ... the effect of other immunological parameter levels, especially ferritin, as a predictor of COVID-19 mortality ... characteristic of COVID-19 infection and an important mediator of morbidity. This study aimed to determine ... of 2568 patients who died (n = 232) and recovered (n = 2336) from COVID-19 in August and December 2021 ...

Abstract	Background and objective: A hyperinflammatory environment is thought to be the distinctive characteristic of COVID-19 infection and an important mediator of morbidity. This study aimed to determine the effect of other immunological parameter levels, especially ferritin, as a predictor of COVID-19 mortality via decision-trees analysis. Material and method: This is a retrospective study evaluating a total of 2568 patients who died (n = 232) and recovered (n = 2336) from COVID-19 in August and December 2021. Immunological laboratory data were compared between two groups that died and recovered from patients with COVID-19. In addition, decision trees from machine learning models were used to evaluate the performance of immunological parameters in the mortality of the COVID-19 disease. Results: Non-surviving from COVID-19 had 1.75 times higher ferritin, 10.7 times higher CRP, 2.4 times higher D-dimer, 1.14 times higher international-normalized-ratio (INR), 1.1 times higher Fibrinogen, 22.9 times higher procalcitonin, 3.35 times higher troponin, 2.77 mm/h times higher erythrocyte-sedimentation-rate (ESR), 1.13sec times longer prothrombin time (PT) when compared surviving patients. In addition, our interpretable decision tree, which was constructed with only the cut-off values of ferritin, INR, and D-dimer, correctly predicted 99.7% of surviving patients and 92.7% of non-surviving patients. Conclusions: This study perfectly predicted the mortality of COVID-19 with our interpretable decision tree constructed with INR and D-dimer, especially ferritin. For this reason, we think that it may be important to include ferritin, INR, and D-dimer parameters and their cut-off values in the scoring systems to be planned for COVID-19 mortality.
Language	English
Publishing date	2023-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e14015
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Article ; Online: Ferritin/lymphocyte percentage ratio to predict the severity and mortality of COVID-19.

Simsek Yurt, Nur / Ocak, Metin

Malawi medical journal : the journal of Medical Association of Malawi

2024 Volume 35, Issue 3, Page(s) 183–189

Abstract: ... reactive protein (CRP), and FLPR levels were independent risk factors for mortality in COVID-19 patients ... percentage ratio (FLPR) with clinical and radiological disease severity and mortality in COVID-19 patients ... of disease severity and mortality in COVID-19. ...

Abstract	Objective: In this study, we aimed to investigate the relationship between ferritin/lymphocyte percentage ratio (FLPR) with clinical and radiological disease severity and mortality in COVID-19 patients. Methods: This retrospective study was conducted with patients who had polymerase chain reaction positive results for COVID-19. We calculated FLPRs from laboratory tests taken during emergency clinic admission. The relationship between chest computed tomography (CT) scores, disease severity, and 30-day mortality with FLPR was evaluated. Results: Our study included 309 patients. 30-day mortality occurred in 12.3% (n=38) of the patients. A statistically significant association was found between FLPR and clinical disease severity (p <0.001). In the post hoc analysis, the difference was caused by the critical and severe groups and FLPR was significantly higher in these groups. A significant correlation was found between CT scores and FLPR (r=0.496, p<0.001). Logistic regression analysis revealed that hypertension, smoking, C-reactive protein (CRP), and FLPR levels were independent risk factors for mortality in COVID-19 patients. In the receiver operating characteristics curve analysis, determined the predictive value and the optimal cut-off value of FLPR. The areas under the curve of WBC, lymphocyte, neutrophil, ferritin, CRP, FLPR were found 0.707, 0.233, 0.735, 0.878, 0.831, 0.924 (p<0.001), respectively. This analysis showed that the FLPR can predict 30-day mortality better than the other biomarkers in the comparison. When the optimal cut-off value of FLPR is 42.4, the sensitivity is 84.2% and specificity is 86.7%. Conclusion: FLPR can be used as an independent biomarker of disease severity and mortality in COVID-19.
MeSH term(s)	Humans ; COVID-19 ; Retrospective Studies ; Prognosis ; Lymphocytes/chemistry ; Lymphocytes/metabolism ; C-Reactive Protein/analysis ; C-Reactive Protein/metabolism
Chemical Substances	C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2024-02-01
Publishing country	Malawi
Document type	Journal Article
ISSN	1995-7270 ; 1995-7262
ISSN (online)	1995-7270
ISSN	1995-7262
DOI	10.4314/mmj.v35i3.8
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