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  1. Article: Pseudothrombotic microangiopathy and vitamin B12 deficiency in pernicious anemia.

    Veit, Kaleb

    Proceedings (Baylor University. Medical Center)

    2016  Volume 30, Issue 3, Page(s) 346–347

    Abstract: ... microangiopathy is anemia, thrombocytopenia, and schistocytosis caused by vitamin B12 deficiency. Pseudothrombotic ... of pseudothrombotic microangiopathy due to severe vitamin B12 deficiency is presented. ... Vitamin B12 deficiency may present as pseudothrombotic microangiopathy. Pseudothrombotic ...

    Abstract Vitamin B12 deficiency may present as pseudothrombotic microangiopathy. Pseudothrombotic microangiopathy is anemia, thrombocytopenia, and schistocytosis caused by vitamin B12 deficiency. Pseudothrombotic microangiopathy may be mistaken for microangiopathic hemolytic anemia, confounding appropriate treatment. Evaluation of lactate dehydrogenase, reticulocyte count, bilirubin, and platelet count are most helpful in differentiating pseudothrombotic microangiopathy from a true microangiopathic hemolytic anemia. A case of pseudothrombotic microangiopathy due to severe vitamin B12 deficiency is presented.
    Language English
    Publishing date 2016-01-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2703932-8
    ISSN 1525-3252 ; 0899-8280
    ISSN (online) 1525-3252
    ISSN 0899-8280
    DOI 10.1080/08998280.2017.11929643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6987: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  2. Article: Pseudothrombotic Microangiopathy as a Rare Presentation of Cobalamin Deficiency.

    Pereira Fontes, Carla / Fonseca, Samuel

    Cureus

    2021  Volume 13, Issue 8, Page(s) e17184

    Abstract: The hematological manifestations of cobalamin (vitamin B12) deficiency may range from asymptomatic ... characterized by the presence of hemolysis and schistocytosis, that is completely reversible after vitamin ... consistent with pernicious anemia. Cobalamin replacement led to the resolution of microangiopathic hemolysis ...

    Abstract The hematological manifestations of cobalamin (vitamin B12) deficiency may range from asymptomatic to life-threatening forms. Pseudothrombotic microangiopathy is a rare but severe presentation, characterized by the presence of hemolysis and schistocytosis, that is completely reversible after vitamin supplementation. We present a challenging diagnostic approach of a 55-year-old man who presented with high hemolytic markers, pancytopenia, and schistocytes on the peripheral smear due to acquired cobalamin deficiency. Subsequent testing revealed positive anti-intrinsic factor and anti-parietal cell antibodies consistent with pernicious anemia. Cobalamin replacement led to the resolution of microangiopathic hemolysis and clinical improvement, thereby confirming the diagnosis. This case highlights the importance of early recognition of this syndrome, which is often misdiagnosed as true microangiopathic hemolytic anemia, confounding appropriate management.
    Language English
    Publishing date 2021-08-14
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.17184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hemolysis and schistocytosis in the emergency department: consider pseudothrombotic microangiopathy related to vitamin B12 deficiency.

    Noël, N / Maigné, G / Tertian, G / Anguel, N / Monnet, X / Michot, J-M / Goujard, C / Lambotte, O

    QJM : monthly journal of the Association of Physicians

    2013  Volume 106, Issue 11, Page(s) 1017–1022

    Abstract: ... 1 × 10(9)/l, P = 0.0023). When compared with 21 patients with vitamin B12 deficiency and anemia ... to vitamin B12 deficiency (pseudo-TMA) at the bedside.: Design and methods: Retrospective study ... of 21 (33.3%) vs. 5 out of 7 (71.4%), respectively] and had lower vitamin B12 levels (105 vs. 45 µmol/l ...

    Abstract Background: Hemolytic anemia with thrombocytopenia and schistocytosis is suggestive of thrombotic thrombocytopenic purpura (TTP). However, these features can occur in the context of vitamin B12 deficiency.
    Aim: To identify simple means of distinguishing between TTP and pseudothrombotic microangiopathies related to vitamin B12 deficiency (pseudo-TMA) at the bedside.
    Design and methods: Retrospective study of patients with pseudo-TMA compared with patients with TTP. The patients with pseudo-TMA were further compared with other cases of cobalamin deficiency, in order to detect factors associated with microangiopathic hemolysis during vitamin B12 deprivation.
    Results: Seven patients with pseudo-TMA were compared with six patients with TTP. The pseudo-TMA patients had higher median lactate dehydrogenase (LDH) levels (7310 vs. 1460 IU/l, P = 0.01), a higher platelet count (73 vs.12.5 × 10(9)/l, P = 0.0023), a lower reticulocyte count (13.1 vs. 265.5 × 10(9)/l, P = 0.0012) and a lower neutrophil count (1.3 vs. 5.1 × 10(9)/l, P = 0.0023). When compared with 21 patients with vitamin B12 deficiency and anemia (but no schistocytosis), the pseudo-TMA patients were more likely to present with pernicious anemia [7 out of 21 (33.3%) vs. 5 out of 7 (71.4%), respectively] and had lower vitamin B12 levels (105 vs. 45 µmol/l, respectively). Vitamin supplementation led to hematological improvements in all pseudo-TMA patients.
    Conclusion: In a context of mechanical hemolysis with thrombocytopenia in a patient admitted to the emergency department, very high LDH levels and a low reticulocyte count are strongly suggestive of pseudo-TMA and should prompt the physician to screen for cobalamin deficiency.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Diagnosis, Differential ; Emergency Service, Hospital ; Erythrocytes, Abnormal ; Female ; Hemolysis ; Humans ; Male ; Middle Aged ; Purpura, Thrombotic Thrombocytopenic/diagnosis ; Purpura, Thrombotic Thrombocytopenic/etiology ; Retrospective Studies ; Thrombotic Microangiopathies/diagnosis ; Thrombotic Microangiopathies/etiology ; Vitamin B 12 Deficiency/complications ; Vitamin B 12 Deficiency/diagnosis
    Language English
    Publishing date 2013-11
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hct142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.131: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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