Article: Linking the Primary Cilium to Cell Migration in Tissue Repair and Brain Development.
2014 Volume 64, Issue 12, Page(s) 1115–1125
Abstract: ... for cell migration, which, when they are aberrantly regulated, lead to defects in organogenesis and tissue ... repair, as well as metastasis of tumors. Here, we present an overview on how primary cilia may contribute ... to the regulation of the cellular signaling pathways that control cyclic processes in directional cell migration. ...
| Abstract | Primary cilia are unique sensory organelles that coordinate cellular signaling networks in vertebrates. Inevitably, defects in the formation or function of primary cilia lead to imbalanced regulation of cellular processes that causes multisystemic disorders and diseases, commonly known as ciliopathies. Mounting evidence has demonstrated that primary cilia coordinate multiple activities that are required for cell migration, which, when they are aberrantly regulated, lead to defects in organogenesis and tissue repair, as well as metastasis of tumors. Here, we present an overview on how primary cilia may contribute to the regulation of the cellular signaling pathways that control cyclic processes in directional cell migration. |
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| Language | English | ||||||||||
| Publishing date | 2014-11-25 | ||||||||||
| Publishing country | England | ||||||||||
| Document type | Journal Article | ||||||||||
| ZDB-ID | 280313-6 | ||||||||||
| ISSN | 0006-3568 | ||||||||||
| ISSN | 0006-3568 | ||||||||||
| DOI | 10.1093/biosci/biu179 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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