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  1. Article ; Online: Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19.

    Vella, Laura A / Giles, Josephine R / Baxter, Amy E / Oldridge, Derek A / Diorio, Caroline / Kuri-Cervantes, Leticia / Alanio, Cécile / Pampena, M Betina / Wu, Jennifer E / Chen, Zeyu / Huang, Yinghui Jane / Anderson, Elizabeth M / Gouma, Sigrid / McNerney, Kevin O / Chase, Julie / Burudpakdee, Chakkapong / Lee, Jessica H / Apostolidis, Sokratis A / Huang, Alexander C /
    Mathew, Divij / Kuthuru, Oliva / Goodwin, Eileen C / Weirick, Madison E / Bolton, Marcus J / Arevalo, Claudia P / Ramos, Andre / Jasen, C J / Conrey, Peyton E / Sayed, Samir / Giannini, Heather M / D'Andrea, Kurt / Meyer, Nuala J / Behrens, Edward M / Bassiri, Hamid / Hensley, Scott E / Henrickson, Sarah E / Teachey, David T / Betts, Michael R / Wherry, E John

    Science immunology

    2021  Volume 6, Issue 57

    Abstract: ... The immune features of MIS-C compared to pediatric COVID-19 or adult disease remain poorly understood ... pediatric COVID-19) and patients with MIS-C. MIS-C patients had patterns of T cell-biased lymphopenia and T ... COVID-19 patients with acute respiratory distress syndrome (ARDS) had sustained immune activation, MIS-C ...

    Abstract Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children, however, present with Multisystem Inflammatory Syndrome in Children (MIS-C) that can lead to vascular complications and shock, but rarely death. The immune features of MIS-C compared to pediatric COVID-19 or adult disease remain poorly understood. We analyzed peripheral blood immune responses in hospitalized SARS-CoV-2 infected pediatric patients (pediatric COVID-19) and patients with MIS-C. MIS-C patients had patterns of T cell-biased lymphopenia and T cell activation similar to severely ill adults, and all patients with MIS-C had SARS-CoV-2 spike-specific antibodies at admission. A distinct feature of MIS-C patients was robust activation of vascular patrolling CX3CR1+ CD8+ T cells that correlated with the use of vasoactive medication. Finally, whereas pediatric COVID-19 patients with acute respiratory distress syndrome (ARDS) had sustained immune activation, MIS-C patients displayed clinical improvement over time, concomitant with decreasing immune activation. Thus, non-MIS-C versus MIS-C SARS-CoV-2 associated illnesses are characterized by divergent immune signatures that are temporally distinct from one another and implicate CD8+ T cells in the clinical presentation and trajectory of MIS-C.
    MeSH term(s) Adolescent ; Adult ; Aging/immunology ; COVID-19/immunology ; Child ; Child, Preschool ; Female ; Flow Cytometry ; Humans ; Leukopenia/immunology ; Lymphocyte Activation ; Male ; Systemic Inflammatory Response Syndrome/immunology ; T-Lymphocytes/immunology ; Young Adult
    Language English
    Publishing date 2021-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abf7570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Deep Immune Profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19.

    Vella, Laura / Giles, Josephine R / Baxter, Amy E / Oldridge, Derek A / Diorio, Caroline / Kuri-Cervantes, Leticia / Alanio, Cecile / Pampena, Maria Betina / Wu, Jennifer E / Chen, Zeyu / Huang, Yinghui Jane / Anderson, Elizabeth M / Gouma, Sigrid / McNerney, Kevin O / Chase, Julie / Burudpakdee, Chakkapong / Lee, Jessica H / Apostolidis, Sokratis A / Huang, Alexander C /
    Mathew, Divij / Kuthuru, Oliva / Goodwin, Eileen C / Weirick, Madison E / Bolton, Marcus J / Arevalo, Claudia P / Ramos, Andre / Jasen, Cristina / Giannini, Heather M / DAndrea, Kurt / Meyer, Nuala J / Behrens, Edward M / Bassiri, Hamid / Hensley, Scott E / Henrickson, Sarah E / Teachey, David T / Betts, Michael R / Wherry, E John

    medRxiv : the preprint server for health sciences

    2020  

    Abstract: ... The immune features of MIS-C compared to pediatric COVID-19 or adult disease remain poorly understood ... pediatric COVID-19) and patients with MIS-C. MIS-C patients had patterns of T cell-biased lymphopenia and T ... cell activation similar to severely ill adults, and all patients with MIS-C had SARS-CoV-2 spike ...

    Abstract Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children, however, present with Multisystem Inflammatory Syndrome in Children (MIS-C) that can lead to vascular complications and shock, but rarely death. The immune features of MIS-C compared to pediatric COVID-19 or adult disease remain poorly understood. We analyzed peripheral blood immune responses in hospitalized SARS-CoV-2 infected pediatric patients (pediatric COVID-19) and patients with MIS-C. MIS-C patients had patterns of T cell-biased lymphopenia and T cell activation similar to severely ill adults, and all patients with MIS-C had SARS-CoV-2 spike-specific antibodies at admission. A distinct feature of MIS-C patients was robust activation of vascular patrolling CX3CR1+ CD8 T cells that correlated with use of vasoactive medication. Finally, whereas pediatric COVID-19 patients with acute respiratory distress syndrome (ARDS) had sustained immune activation, MIS-C patients displayed clinical improvement over time, concomitant with decreasing immune activation. Thus, non-MIS-C versus MIS-C SARS-CoV-2 associated illnesses are characterized by divergent immune signatures that are temporally distinct and implicate CD8 T cells in clinical presentation and trajectory of MIS-C.
    Keywords covid19
    Language English
    Publishing date 2020-10-06
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2020.09.25.20201863
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Deep Immune Profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19

    Vella, Laura / Giles, Josephine R. / Baxter, Amy E. / Oldridge, Derek A / Diorio, Caroline / Alanio, Cecile / Pampena, Maria Betina / Wu, Jennifer E / Chen, Zeyu / Huang, Yinghui Jane / Anderson, Elizabeth M. / Gouma, Sigrid / McNerney, Kevin O. / Chase, Julie / Burudpakdee, Chakkapong / Lee, Jessica H. / Apostolidis, Sokratis A. / Huang, Alexander C. / Mathew, Divij /
    Kuthuru, Oliva / Goodwin, Eileen C. / Weirick, Madison E. / Bolton, Marcus J. / Arevalo, Claudia P. / Ramos, Andre / Jasen, Cristina / Giannini, Heather M. / DAndrea, Kurt / The UPenn COVID Processing Unit / Meyer, Nuala J. / Behrens, Edward M. / Bassiri, Hamid / Hensley, Scott E. / Henrickson, Sarah E. / Teachey, David T. / Betts, Michael Michael R. / Wherry, E. John

    medRxiv

    Abstract: ... The immune features of MIS-C compared to pediatric COVID-19 or adult disease remain poorly understood ... pediatric COVID-19) and patients with MIS-C. MIS-C patients had patterns of T cell-biased lymphopenia and T ... cell activation similar to severely ill adults, and all patients with MIS-C had SARS-CoV-2 spike ...

    Abstract Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children, however, present with Multisystem Inflammatory Syndrome in Children (MIS-C) that can lead to vascular complications and shock, but rarely death. The immune features of MIS-C compared to pediatric COVID-19 or adult disease remain poorly understood. We analyzed peripheral blood immune responses in hospitalized SARS-CoV-2 infected pediatric patients (pediatric COVID-19) and patients with MIS-C. MIS-C patients had patterns of T cell-biased lymphopenia and T cell activation similar to severely ill adults, and all patients with MIS-C had SARS-CoV-2 spike-specific antibodies at admission. A distinct feature of MIS-C patients was robust activation of vascular patrolling CX3CR1+ CD8 T cells that correlated with use of vasoactive medication. Finally, whereas pediatric COVID-19 patients with acute respiratory distress syndrome (ARDS) had sustained immune activation, MIS-C patients displayed clinical improvement over time, concomitant with decreasing immune activation. Thus, non-MIS-C versus MIS-C SARS-CoV-2 associated illnesses are characterized by divergent immune signatures that are temporally distinct and implicate CD8 T cells in clinical presentation and trajectory of MIS-C.
    Keywords covid19
    Language English
    Publishing date 2020-09-27
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.09.25.20201863
    Database COVID19

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Deep Immune Profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19

    Vella, L. / Giles, J. R. / Baxter, A. E. / Oldridge, D. A. / Diorio, C. / Alanio, C. / Pampena, M. B. / Wu, J. E. / Chen, Z. / Huang, Y. J. / Anderson, E. M. / Gouma, S. / McNerney, K. O. / Chase, J. / Burudpakdee, C. / Lee, J. H. / Apostolidis, S. A. / Huang, A. C. / Mathew, D. /
    Kuthuru, O. / Goodwin, E. C. / Weirick, M. E. / Bolton, M. J. / Arevalo, C. P. / Ramos, A. / Jasen, C. / Giannini, H. M. / K, D. Andrea / Meyer, N. J. / Behrens, E. M. / Bassiri, H. / Hensley, S. E. / Henrickson, S. E. / Teachey, D. T. / Betts, M. M. R. / Wherry, E. J.

    medRxiv

    Abstract: ... features of MIS-C compared to pediatric COVID-19 or adult disease remain poorly understood We analyzed ... Syndrome in Children (MIS-C) that can lead to vascular complications and shock, but rarely death The immune ... and patients with MIS-C MIS-C patients had patterns of T cell-biased lymphopenia and T cell activation ...

    Abstract Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults A subset of children, however, present with Multisystem Inflammatory Syndrome in Children (MIS-C) that can lead to vascular complications and shock, but rarely death The immune features of MIS-C compared to pediatric COVID-19 or adult disease remain poorly understood We analyzed peripheral blood immune responses in hospitalized SARS-CoV-2 infected pediatric patients (pediatric COVID-19) and patients with MIS-C MIS-C patients had patterns of T cell-biased lymphopenia and T cell activation similar to severely ill adults, and all patients with MIS-C had SARS-CoV-2 spike-specific antibodies at admission A distinct feature of MIS-C patients was robust activation of vascular patrolling CX3CR1+ CD8 T cells that correlated with use of vasoactive medication Finally, whereas pediatric COVID-19 patients with acute respiratory distress syndrome (ARDS) had sustained immune activation, MIS-C patients displayed clinical improvement over time, concomitant with decreasing immune activation Thus, non-MIS-C versus MIS-C SARS-CoV-2 associated illnesses are characterized by divergent immune signatures that are temporally distinct and implicate CD8 T cells in clinical presentation and trajectory of MIS-C
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #807631
    Database COVID19

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