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  1. Article ; Online: Ocular manifestations of emerging viral diseases.

    Venkatesh, Ashwin / Patel, Ravi / Goyal, Simran / Rajaratnam, Timothy / Sharma, Anant / Hossain, Parwez

    Eye (London, England)

    2021  Volume 35, Issue 4, Page(s) 1117–1139

    Abstract: ... those emerging viral diseases associated with reports of ocular manifestations and summarizes details pertinent ... Emerging infectious diseases should therefore be considered in the differential diagnosis of ocular inflammatory conditions ... Emerging infectious diseases (EIDs) are an increasing threat to public health on a global scale ...

    Abstract Emerging infectious diseases (EIDs) are an increasing threat to public health on a global scale. In recent times, the most prominent outbreaks have constituted RNA viruses, spreading via droplets (COVID-19 and Influenza A H1N1), directly between humans (Ebola and Marburg), via arthropod vectors (Dengue, Zika, West Nile, Chikungunya, Crimean Congo) and zoonotically (Lassa fever, Nipah, Rift Valley fever, Hantaviruses). However, specific approved antiviral therapies and vaccine availability are scarce, and public health measures remain critical. Patients can present with a spectrum of ocular manifestations. Emerging infectious diseases should therefore be considered in the differential diagnosis of ocular inflammatory conditions in patients inhabiting or returning from endemic territories, and more general vigilance is advisable in the context of a global pandemic. Eye specialists are in a position to facilitate swift diagnosis, improve clinical outcomes, and contribute to wider public health efforts during outbreaks. This article reviews those emerging viral diseases associated with reports of ocular manifestations and summarizes details pertinent to practicing eye specialists.
    MeSH term(s) Animals ; Arthropod Vectors ; Communicable Diseases, Emerging/diagnosis ; Communicable Diseases, Emerging/epidemiology ; Disease Outbreaks ; Eye Infections, Viral/diagnosis ; Eye Infections, Viral/epidemiology ; Humans ; RNA Viruses/pathogenicity ; Viral Zoonoses ; Virus Diseases/diagnosis ; Virus Diseases/epidemiology
    Language English
    Publishing date 2021-01-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-020-01376-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online ; E-Book: Emerging ocular infections

    Lowder, Careen Y. / Shrestha, Nabin / Venkat, Arthi

    (Essentials in Ophthalmology,)

    2023  

    Abstract: ... Emerging Ocular Infection will be of use to ID specialists, and ophthalmologists alike. ... manifestations of infectious disease from a novel perspective. Each chapter is co-written by an ophthalmologist ... covers infections such as viral retinitis, fungal infections, syphilis, tuberculosis, vector-borne ...

    Author's details edited by Careen Y. Lowder, Nabin Shrestha, and Arthi Venkat
    Series title Essentials in Ophthalmology,
    Abstract The book offers comprehensive coverage on novel manifestations of known infections, novel infections with documented ophthalmic involvement, and the growing issue of resistance among certain infections. Filling a much-needed gap in current literary offerings, chapters approach ophthalmic manifestations of infectious disease from a novel perspective. Each chapter is co-written by an ophthalmologist and an infectious disease specialist to provide multidisciplinary insight. This unique analysis of infectious disease enhances the ability of ophthalmologists and infectious disease specialists to identify the manifold manifestations of both common and rare infections in the eye. Chapters begin with a general introduction, and each contain an Infectious Disease section, along with an Ophthalmology section. The book covers infections such as viral retinitis, fungal infections, syphilis, tuberculosis, vector-borne illnesses, and delve into rarer conditions such as unusual post-operative infections. Concise and practical, Emerging Ocular Infection will be of use to ID specialists, and ophthalmologists alike.
    MeSH term(s) Eye Infections ; Infections/immunology. ; Mycobacterium Infections. ; Nontuberculous Mycobacteria. ; Mycobacterium Infections, Nontuberculous. ; Eye Diseases.
    Keywords Eye/Infections ; Mycoses/Immunological aspects ; Mycobacterial diseases ; Tuberculosis ; Eye/Diseases
    Subject code 617.71
    Language English
    Dates of publication 2023-2023
    Size 1 online resource (119 pages)
    Publisher Springer Nature Switzerland AG
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-031-24559-8 ; 9783031245589 ; 978-3-031-24559-6 ; 303124558X
    DOI 10.1007/978-3-031-24559-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Systemic and Ocular Manifestations of Arboviral Infections: A Review.

    Khairallah, Moncef / Abroug, Nesrine / Smit, Derrick / Chee, Soon-Phaik / Nabi, Wijden / Yeh, Steven / Smith, Justine R / Ksiaa, Imen / Cunningham, Emmett

    Ocular immunology and inflammation

    2024  , Page(s) 1–19

    Abstract: ... systemic and ocular manifestations, diagnosis, treatment, and prognosis of arboviral diseases including ... to prevent human infection and disease.: Conclusion: Emerging arboviral diseases should be considered ... of arboviral diseases is confirmed with either real time polymerase chain reaction or serology. Management involves ...

    Abstract Purpose: To provide an overview of pre-selected emerging arboviruses (arthropod-borne viruses) that cause ocular inflammation in humans.
    Methods: A comprehensive review of the literature published between 1997 and 2023 was conducted in PubMed database. We describe current insights into epidemiology, systemic and ocular manifestations, diagnosis, treatment, and prognosis of arboviral diseases including West Nile fever, Dengue fever, Chikungunya, Rift Valley fever, Zika, and Yellow fever.
    Results: Arboviruses refer to a group of ribonucleic acid viruses transmitted to humans by the bite of hematophagous arthropods, mainly mosquitoes. They mostly circulate in tropical and subtropical zones and pose important public health challenges worldwide because of rising incidence, expanding geographic range, and occurrence of prominent outbreaks as a result of climate change, travel, and globalization. The clinical signs associated with infection from these arboviruses are often inapparent, mild, or non-specific, but they may include serious, potentially disabling or life-threatening complications. A wide spectrum of ophthalmic manifestations has been described including conjunctival involvement, anterior uveitis, intermediate uveitis, various forms of posterior uveitis, maculopathy, optic neuropathy, and other neuro-ophthalmic manifestations. Diagnosis of arboviral diseases is confirmed with either real time polymerase chain reaction or serology. Management involves supportive care as there are currently no specific antiviral drug options. Corticosteroids are often used for the treatment of associated ocular inflammation. Most patients have a good visual prognosis, but there may be permanent visual impairment due to ocular structural complications in some. Community-based integrated mosquito management programs and personal protection measures against mosquito bites are the best ways to prevent human infection and disease.
    Conclusion: Emerging arboviral diseases should be considered in the differential diagnosis of ocular inflammatory conditions in patients living in or returning from endemic regions. Early clinical consideration followed by confirmatory testing can limit or prevent unnecessary treatments for non-arboviral causes of ocular inflammation. Prevention of these infections is crucial.
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2024.2320724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ocular manifestations of COVID-19 in the pediatric age group.

    Alnahdi, Muhannad A / Alkharashi, Maan

    European journal of ophthalmology

    2022  , Page(s) 11206721221116210

    Abstract: ... in the literature with this emerging viral illness. Conjunctivitis was the most common ocular manifestation in MIS-C ... in the pediatric age group. We aim to outline the various pediatric ocular manifestations described ... infection. Ocular manifestations have virtually affected all ages. They manifested in neonates, infants ...

    Abstract The coronavirus disease 2019 (COVID-19) is now known to be associated with several ocular manifestations. The literature thoroughly discussed those that affect adults, with a lesser focus in the pediatric age group. We aim to outline the various pediatric ocular manifestations described in the literature. The manifestations may be divided into isolated events attributed to COVID-19 or occurring in the new multisystem inflammatory syndrome in children (MIS-C), a novel entity associated by COVID-19 infection. Ocular manifestations have virtually affected all ages. They manifested in neonates, infants, children, and adolescents. Episcleritis, conjunctivitis, optic neuritis, cranial nerve palsies, retinal vein occlusion, retinal vasculitis, retinal changes, orbital myositis, orbital cellulitis were reported in the literature with this emerging viral illness. Conjunctivitis was the most common ocular manifestation in MIS-C in nearly half of the patients. Other ocular manifestations in MIS-C were anterior uveitis, corneal epitheliopathy, optic neuritis, idiopathic intracranial hypertension, and retinitis. The clinical outcome was favorable, and children regain their visual ability with minimal or no deficits in most of the cases. Further follow-up may be warranted to better understand the long-term effects and visual prognosis.
    Language English
    Publishing date 2022-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/11206721221116210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Ocular Manifestations of Emerging Arthropod-Borne Infectious Diseases.

    Abroug, Nesrine / Khairallah, Molka / Zina, Sourour / Ksiaa, Imen / Amor, Hager Ben / Attia, Sonia / Jelliti, Bechir / Khochtali, Sana / Khairallah, Moncef

    Journal of current ophthalmology

    2021  Volume 33, Issue 3, Page(s) 227–235

    Abstract: ... associated with an array of ocular manifestations. These include anterior uveitis, retinitis, chorioretinitis ... rickettsial disease, West Nile virus, Dengue fever, Chikungunya, Rift valley fever, and Zika virus have been ... of arthropod-borne infectious diseases.: Methods: This is a narrative review on arthropod-borne ...

    Abstract Purpose: To review the clinical features, diagnosis, treatment modalities, and prognosis of arthropod-borne infectious diseases.
    Methods: This is a narrative review on arthropod-borne infectious diseases including general and ophthalmological aspects of these infectious diseases. A comprehensive literature review between January 1983 and September 2020 was conducted in PubMed database. Epidemiology, clinical features, diagnosis, treatment, and prognosis of arthropod-borne infectious diseases were reviewed.
    Results: Emergent and resurgent arthropod-borne infectious diseases are major causes of systemic morbidity and death that are expanding worldwide. Among them, bacterial and viral agents including rickettsial disease, West Nile virus, Dengue fever, Chikungunya, Rift valley fever, and Zika virus have been associated with an array of ocular manifestations. These include anterior uveitis, retinitis, chorioretinitis, retinal vasculitis, and optic nerve involvement. Proper clinical diagnosis of any of these infectious diseases is primarily based on epidemiological data, history, systemic symptoms and signs, and the pattern of ocular involvement. The diagnosis is confirmed by laboratory tests. Ocular involvement usually has a self-limited course, but it can result in persistent visual impairment. Doxycycline is the treatment of choice for rickettsial disease. There is currently no proven specific treatment for arboviral diseases. Prevention remains the mainstay for arthropod vector and zoonotic disease control.
    Conclusions: Emerging arthropod vector-borne diseases should be considered in the differential diagnosis of uveitis, especially in patient living or with recent travel to endemic countries. Early clinical diagnosis, while laboratory testing is pending, is essential for proper management to prevent systemic and ocular morbidity.
    Language English
    Publishing date 2021-10-22
    Publishing country India
    Document type Journal Article ; Review
    ISSN 2452-2325
    ISSN 2452-2325
    DOI 10.4103/joco.joco_134_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Ocular immune reconstitution inflammatory syndrome].

    Ma, N / Ye, J J

    Zhonghua yan ke za zhi] Chinese journal of ophthalmology

    2016  Volume 52, Issue 2, Page(s) 150–153

    Abstract: ... associated with paradoxical worsening of preexisting infectious processes or emerging diseases or even dead ... immune reconstitution inflammatory syndrome is mainly caused by cytomegalovirus which performing a series of ocular inflammation accompanied ... HIV) infected individuals in a period of recovery of immune function. Ocular ...

    Abstract Immune reconstitution inflammatory syndrome (IRIS) is a collection of inflammatory disorders associated with paradoxical worsening of preexisting infectious processes or emerging diseases or even dead after the initiation of highly active antiretroviral therapy (HAART) in human immunodeficiency virus (HIV) infected individuals in a period of recovery of immune function. Ocular immune reconstitution inflammatory syndrome is mainly caused by cytomegalovirus which performing a series of ocular inflammation accompanied with the increase of CD4+ T lymphocytes, such as cytomegalovirus retinitis, after HAART. With HAART widely used, the patients of IRIS gradually increased. But the clinical presentations of IRIS were various because of different pathogens. This review summarized the clinical manifestations, risk factors, diagnosis and treatment of ocular IRIS.
    MeSH term(s) Antiretroviral Therapy, Highly Active/adverse effects ; CD4-Positive T-Lymphocytes ; Cytomegalovirus Retinitis/etiology ; HIV Infections ; Humans ; Immune Reconstitution Inflammatory Syndrome/drug therapy ; Immune Reconstitution Inflammatory Syndrome/etiology ; Immune Reconstitution Inflammatory Syndrome/immunology ; Risk Factors
    Language Chinese
    Publishing date 2016-02
    Publishing country China
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 604574-1
    ISSN 0412-4081
    ISSN 0412-4081
    DOI 10.3760/cma.j.issn.0412-4081.2016.02.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ocular Manifestations of Emerging Flaviviruses and the Blood-Retinal Barrier.

    Singh, Sneha / Kumar, Ashok

    Viruses

    2018  Volume 10, Issue 10

    Abstract: ... manifestations of these mosquito-transmitted viruses are considered relatively uncommon in part due to under ... reporting. However, recent outbreaks of Zika virus (ZIKV) implicated in causing multiple ocular ... to the pathogenesis of ocular manifestations and assist in the development of ocular antiviral therapies against ZIKV ...

    Abstract Despite flaviviruses remaining the leading cause of systemic human infections worldwide, ocular manifestations of these mosquito-transmitted viruses are considered relatively uncommon in part due to under-reporting. However, recent outbreaks of Zika virus (ZIKV) implicated in causing multiple ocular abnormalities, such as conjunctivitis, retinal hemorrhages, chorioretinal atrophy, posterior uveitis, optic neuritis, and maculopathies, has rejuvenated a significant interest in understanding the pathogenesis of flaviviruses, including ZIKV, in the eye. In this review, first, we summarize the current knowledge of the major flaviviruses (Dengue, West Nile, Yellow Fever, and Japanese Encephalitis) reported to cause ocular manifestations in humans with emphasis on recent ZIKV outbreaks. Second, being an immune privilege organ, the eye is protected from systemic infections by the presence of blood-retinal barriers (BRB). Hence, we discuss how flaviviruses modulate retinal innate response and breach the protective BRB to cause ocular or retinal pathology. Finally, we describe recently identified infection signatures of ZIKV and discuss whether these system biology-predicted genes or signaling pathways (e.g., cellular metabolism) could contribute to the pathogenesis of ocular manifestations and assist in the development of ocular antiviral therapies against ZIKV and other flaviviruses.
    MeSH term(s) Animals ; Blood-Retinal Barrier/pathology ; Blood-Retinal Barrier/virology ; Culicidae/virology ; Disease Models, Animal ; Eye Infections/immunology ; Eye Infections/transmission ; Eye Infections/virology ; Flavivirus/immunology ; Flavivirus/pathogenicity ; Flavivirus Infections/immunology ; Flavivirus Infections/transmission ; Flavivirus Infections/virology ; Humans ; Immunity, Innate/immunology ; Mice ; Mice, Knockout ; Retina/immunology ; Retina/pathology ; Retina/virology
    Keywords covid19
    Language English
    Publishing date 2018-09-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v10100530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Ocular surface assessment in times of sanitary crisis: What lessons and solutions for the present and the future?

    Labetoulle, Marc / Sahyoun, Marwan / Rousseau, Antoine / Baudouin, Christophe

    European journal of ophthalmology

    2020  Volume 31, Issue 2, Page(s) 807–816

    Abstract: ... a standard ophthalmic examination for the assessment of ocular surface diseases. While waiting for new ... Ophthalmologists have been largely impacted by the COVID-19 sanitary crisis, due to both the ocular manifestations ... of SARS-CoV-2 and to the high contagiousness of the virus. The proximity of ophthalmologists ...

    Abstract Purpose: To describe the immediate consequences of SARS-CoV-2 and the COVID-19 pandemic on the ocular surface and eye-care professionals, and to discuss the need for a mandatory switch from currently performed tele-screening to true teleconsultation for remote ocular surface assessment.
    Main findings: Ophthalmologists have been largely impacted by the COVID-19 sanitary crisis, due to both the ocular manifestations of SARS-CoV-2 and to the high contagiousness of the virus. The proximity of ophthalmologists to their patients have pushed eye-care providers to readapt their practices and develop alternatives to face-to-face consultations. However, teleconsultation has some major limitations and drawbacks, especially for ocular surface assessment that relies on high-quality graphic data for adequate diagnosis. Tele-screening, on the other hand, emphasizes on the importance of history-taking and listening to the patient in order to adequately prioritize appointments based on the presumed degree of emergency.
    Conclusion: Despite all the enthusiasm, tele-screening as currently performed with the available tools is still not capable of completely replacing a standard ophthalmic examination for the assessment of ocular surface diseases. While waiting for new emerging technologies and future implementation of imaging modalities and artificial intelligence, decision making algorithms can help eye-practitioners remotely screen their patients to assess the optimal time for follow-up appointments.
    MeSH term(s) COVID-19/epidemiology ; Communicable Disease Control/methods ; Conjunctival Diseases/diagnosis ; Corneal Diseases/diagnosis ; Delivery of Health Care/trends ; Dry Eye Syndromes/diagnosis ; Health Personnel ; Humans ; Ophthalmology/trends ; Physical Examination/methods ; SARS-CoV-2 ; Telemedicine/methods
    Language English
    Publishing date 2020-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/1120672120978881
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Ocular manifestations of emerging infectious diseases.

    Khairallah, Moncef / Kahloun, Rim

    Current opinion in ophthalmology

    2013  Volume 24, Issue 6, Page(s) 574–580

    Abstract: ... manifestations of selected emerging infectious diseases relevant to the ophthalmologist.: Recent findings ... Among them, specific diseases have been recently associated with ocular involvement. This review presents the ocular ... Emerging infectious diseases should be considered in the differential diagnosis of retinitis, chorioretinitis ...

    Abstract Purpose of review: Emergent and resurgent infectious diseases are major causes of systemic morbidity and death that are expanding worldwide mainly because of climate changes and globalization. Among them, specific diseases have been recently associated with ocular involvement. This review presents the ocular manifestations of selected emerging infectious diseases relevant to the ophthalmologist.
    Recent findings: An array of ocular manifestations, involving mainly the posterior segment, have been recently described in association with specific arthropod vector-borne diseases including rickettsioses, West Nile virus, Rift Valley fever, Dengue fever, and Chikungunya. Influenza A (H1N1) virus has also been recently associated with ocular involvement. On the contrary, with advances in laboratory testing applied to ocular fluids, new infectious agents, mainly viruses, are increasingly being found to be associated with uveitis.
    Summary: Emerging infectious diseases should be considered in the differential diagnosis of retinitis, chorioretinitis, retinal vasculitis, optic neuropathy, or any other ocular inflammatory condition in a patient living in or traveling back from a specific endemic area. On the contrary, ocular fluid sampling and analysis for specific new pathogens can be recommended in selected patients with uveitis of unexplained cause.
    MeSH term(s) Communicable Diseases, Emerging/diagnosis ; Diagnosis, Differential ; Eye Diseases/diagnosis ; Eye Infections/diagnosis ; Humans
    Language English
    Publishing date 2013-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1049383-9
    ISSN 1531-7021 ; 1040-8738
    ISSN (online) 1531-7021
    ISSN 1040-8738
    DOI 10.1097/ICU.0b013e3283654e09
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Ocular manifestations of emerging arboviruses: Dengue fever, Chikungunya, Zika virus, West Nile virus, and yellow fever.

    Merle, H / Donnio, A / Jean-Charles, A / Guyomarch, J / Hage, R / Najioullah, F / Césaire, R / Cabié, A

    Journal francais d'ophtalmologie

    2018  Volume 41, Issue 6, Page(s) e235–e243

    Abstract: Arboviruses are viral diseases transmitted by mosquitoes and tick bites. They are a major cause ... of this review is to describe the ophthalmological manifestations of Dengue fever, Chikungunya virus, Zika virus ... treatments or vaccines. Ocular manifestations due to those infections are thus more frequent and increasingly ...

    Abstract Arboviruses are viral diseases transmitted by mosquitoes and tick bites. They are a major cause of morbidity and sometimes mortality. Their expansion is constant and due in part to climate change and globalization. Mostly found in tropical regions, arboviruses are sometimes the source of epidemics in Europe. Recently, the Chikungunya virus and the Zika virus were responsible for very large epidemics impacting populations that had never been in contact with those viruses. There are currently no effective antiviral treatments or vaccines. Ocular manifestations due to those infections are thus more frequent and increasingly better described. They are sometimes, as with Zika, complicated by a congenital ocular syndrome. The goal of this review is to describe the ophthalmological manifestations of Dengue fever, Chikungunya virus, Zika virus, West Nile virus, and yellow fever.
    MeSH term(s) Arbovirus Infections/diagnosis ; Arbovirus Infections/epidemiology ; Arbovirus Infections/virology ; Arboviruses/classification ; Arboviruses/isolation & purification ; Chikungunya Fever/complications ; Chikungunya Fever/diagnosis ; Chikungunya Fever/epidemiology ; Chikungunya virus/isolation & purification ; Chikungunya virus/physiology ; Communicable Diseases, Emerging/diagnosis ; Communicable Diseases, Emerging/epidemiology ; Communicable Diseases, Emerging/virology ; Dengue/complications ; Dengue/diagnosis ; Dengue/epidemiology ; Eye Infections, Viral/diagnosis ; Eye Infections, Viral/epidemiology ; Eye Infections, Viral/virology ; Humans ; West Nile virus/isolation & purification ; West Nile virus/physiology ; Yellow Fever/complications ; Yellow Fever/diagnosis ; Yellow Fever/epidemiology ; Zika Virus/isolation & purification ; Zika Virus/physiology ; Zika Virus Infection/complications ; Zika Virus Infection/diagnosis ; Zika Virus Infection/epidemiology
    Language English
    Publishing date 2018-06-19
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 426662-6
    ISSN 1773-0597 ; 0181-5512
    ISSN (online) 1773-0597
    ISSN 0181-5512
    DOI 10.1016/j.jfo.2018.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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