Article ; Online: Polycystin-1 dysfunction impairs electrolyte and water handling in a renal precystic mouse model for ADPKD.
American journal of physiology. Renal physiology
2018 Volume 315, Issue 3, Page(s) F537–F546
Abstract: ... polycystic kidney disease (ADPKD). The involvement of PC1 in renal electrolyte handling remains unknown since renal ... the renal electrolyte handling in inducible kidney-specific Pkd1 knockout (iKsp- Pkd1 ... electrolyte physiology in ADPKD patients has only been characterized in cystic ADPKD. We thus studied ...
| Abstract | The PKD1 gene encodes polycystin-1 (PC1), a mechanosensor triggering intracellular responses upon urinary flow sensing in kidney tubular cells. Mutations in PKD1 lead to autosomal dominant polycystic kidney disease (ADPKD). The involvement of PC1 in renal electrolyte handling remains unknown since renal electrolyte physiology in ADPKD patients has only been characterized in cystic ADPKD. We thus studied the renal electrolyte handling in inducible kidney-specific Pkd1 knockout (iKsp- Pkd1 |
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| MeSH term(s) | Animals ; Body Water/metabolism ; Calcium/metabolism ; Disease Models, Animal ; Electrolytes/blood ; Electrolytes/metabolism ; Electrolytes/urine ; Gene Expression Regulation ; Intestinal Absorption ; Kidney/metabolism ; Kidney/physiopathology ; Magnesium/metabolism ; Male ; Mice, Knockout ; Polycystic Kidney, Autosomal Dominant/genetics ; Polycystic Kidney, Autosomal Dominant/metabolism ; Polycystic Kidney, Autosomal Dominant/physiopathology ; Renal Reabsorption ; TRPP Cation Channels/deficiency ; TRPP Cation Channels/genetics ; Water-Electrolyte Balance/genetics | |||||
| Chemical Substances | Electrolytes ; TRPP Cation Channels ; polycystic kidney disease 1 protein ; Magnesium (I38ZP9992A) ; Calcium (SY7Q814VUP) | |||||
| Language | English | |||||
| Publishing date | 2018-05-16 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 603837-2 | |||||
| ISSN | 1522-1466 ; 0363-6127 | |||||
| ISSN (online) | 1522-1466 | |||||
| ISSN | 0363-6127 | |||||
| DOI | 10.1152/ajprenal.00622.2017 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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