Article ; Online: Invasive pulmonary aspergillosis in COVID-19 critically ill patients: Results of a French monocentric cohort.
2021 Volume 31, Issue 2, Page(s) 101122
Abstract: ... These results are however different from the previous publications on COVID-19 patients and must therefore be ... in a cohort of COVID-19 patients with moderate to severe acute respiratory disease syndrome (ARDS ... a putative IPA during their stay.: Conclusion: The prevalence of IPA in this cohort of COVID-19 patients ...
| Abstract | Introduction: Coronavirus disease 2019 or COVID-19 is a new infectious disease responsible for potentially severe respiratory impairment associated with initial immunosuppression. Similarly to influenza, several authors have described a higher risk of fungal infection after COVID-19, in particular for invasive pulmonary aspergillosis. The main objective here is to define the prevalence of invasive pulmonary aspergillosis (IPA) in a cohort of COVID-19 patients with moderate to severe acute respiratory disease syndrome (ARDS). Material and methods: We conducted a large monocentric retrospective study investigating all the ventilated COVID-19 patients with ARDS hospitalized at Valenciennes' general hospital, France, between March 15, 2020 and April 30, 2020. In the center a systematic IPA screening strategy was carried out for all ARDS patients, with weekly tests of serum galactomannan and beta-D-glucan. Bronchoalveolar lavage with culture and chest CT scan were performed when the serum assays were positives. Results: A total of 54 patients were studied. Their median age was 65 years, and 37 of the patients (71%) were male. Two patients had chronic immunosuppression and among all the patients, only 2 non-immunocompromised presented a putative IPA during their stay. Conclusion: The prevalence of IPA in this cohort of COVID-19 patients (3.7%) is not higher than what is described in the other ARDS populations in the literature. These results are however different from the previous publications on COVID-19 patients and must therefore be confirmed by larger and multicentric studies. |
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| MeSH term(s) | Adult ; Aged ; Aged, 80 and over ; Biomarkers ; COVID-19/complications ; Comorbidity ; Critical Illness ; Female ; France/epidemiology ; Galactose/analogs & derivatives ; Hospitals, General/statistics & numerical data ; Humans ; Immunocompromised Host ; Intensive Care Units/statistics & numerical data ; Invasive Pulmonary Aspergillosis/complications ; Invasive Pulmonary Aspergillosis/diagnosis ; Male ; Mannans/blood ; Middle Aged ; Opportunistic Infections/complications ; Respiration, Artificial ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy ; Retrospective Studies ; Risk Factors ; beta-Glucans/blood | |||||
| Chemical Substances | Biomarkers ; Mannans ; beta-Glucans ; galactomannan (11078-30-1) ; Galactose (X2RN3Q8DNE) | |||||
| Language | English | |||||
| Publishing date | 2021-02-16 | |||||
| Publishing country | France | |||||
| Document type | Case Reports ; Journal Article | |||||
| ZDB-ID | 1067006-3 | |||||
| ISSN | 1773-0449 ; 1156-5233 | |||||
| ISSN (online) | 1773-0449 | |||||
| ISSN | 1156-5233 | |||||
| DOI | 10.1016/j.mycmed.2021.101122 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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