Article ; Online: Glutamoptosis: A new cell death mechanism inhibited by autophagy during nutritional imbalance.
2017 Volume 13, Issue 6, Page(s) 1078–1079
Abstract: ... cell death. Thus, autophagy controls glutamoptosis during nutritional imbalance. ... of glutaminolysis during nutritional restriction causes a particular form of apoptotic cell death, that we termed ... glutamoptosis." We found that the inhibition of autophagy is a key step to allow glutamoptosis-mediated ...
| Abstract | Glutaminolysis plays a critical role in nutrient sufficiency and cell signaling activation in mammalian cells. Unexpectedly, our recent investigations revealed that the unbalanced activation of glutaminolysis during nutritional restriction causes a particular form of apoptotic cell death, that we termed "glutamoptosis." We found that the inhibition of autophagy is a key step to allow glutamoptosis-mediated cell death. Thus, autophagy controls glutamoptosis during nutritional imbalance. |
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| Language | English | |||||
| Publishing date | 2017-06-03 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 2454135-7 | |||||
| ISSN | 1554-8635 ; 1554-8627 | |||||
| ISSN (online) | 1554-8635 | |||||
| ISSN | 1554-8627 | |||||
| DOI | 10.1080/15548627.2017.1299315 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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